A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model. / Jie, Zhuye; Zhu, Qian; Zou, Yuanqiang; Wu, Qili; Qin, Min; He, Dongdong; Lin, Xiaoqian; Tong, Xin; Zhang, Jiahao; Jie, Zhu; Luo, Wenwei; Xiao, Xiao; Chen, Shiyu; Wu, Yonglin; Guo, Gongjie; Zheng, Shufen; Li, Yong; Lai, Weihua; Yang, Huanming; Wang, Jian; Xiao, Liang; Chen, Jiyan; Zhang, Tao; Kristiansen, Karsten; Jia, Huijue; Zhong, Shilong.

In: iScience, Vol. 26, No. 6, 106960, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jie, Z, Zhu, Q, Zou, Y, Wu, Q, Qin, M, He, D, Lin, X, Tong, X, Zhang, J, Jie, Z, Luo, W, Xiao, X, Chen, S, Wu, Y, Guo, G, Zheng, S, Li, Y, Lai, W, Yang, H, Wang, J, Xiao, L, Chen, J, Zhang, T, Kristiansen, K, Jia, H & Zhong, S 2023, 'A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model', iScience, vol. 26, no. 6, 106960. https://doi.org/10.1016/j.isci.2023.106960

APA

Jie, Z., Zhu, Q., Zou, Y., Wu, Q., Qin, M., He, D., Lin, X., Tong, X., Zhang, J., Jie, Z., Luo, W., Xiao, X., Chen, S., Wu, Y., Guo, G., Zheng, S., Li, Y., Lai, W., Yang, H., ... Zhong, S. (2023). A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model. iScience, 26(6), [106960]. https://doi.org/10.1016/j.isci.2023.106960

Vancouver

Jie Z, Zhu Q, Zou Y, Wu Q, Qin M, He D et al. A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model. iScience. 2023;26(6). 106960. https://doi.org/10.1016/j.isci.2023.106960

Author

Jie, Zhuye ; Zhu, Qian ; Zou, Yuanqiang ; Wu, Qili ; Qin, Min ; He, Dongdong ; Lin, Xiaoqian ; Tong, Xin ; Zhang, Jiahao ; Jie, Zhu ; Luo, Wenwei ; Xiao, Xiao ; Chen, Shiyu ; Wu, Yonglin ; Guo, Gongjie ; Zheng, Shufen ; Li, Yong ; Lai, Weihua ; Yang, Huanming ; Wang, Jian ; Xiao, Liang ; Chen, Jiyan ; Zhang, Tao ; Kristiansen, Karsten ; Jia, Huijue ; Zhong, Shilong. / A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model. In: iScience. 2023 ; Vol. 26, No. 6.

Bibtex

@article{261cc084be594a7b89347ddd260725d9,
title = "A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model",
abstract = "By a survey of metagenome-wide association studies (MWAS), we found a robust depletion of Bacteroides cellulosilyticus, Faecalibacterium prausnitzii, and Roseburia intestinalis in individuals with atherosclerotic cardiovascular disease (ACVD). From an established collection of bacteria isolated from healthy Chinese individuals, we selected B. cellulosilyticus, R. intestinalis, and Faecalibacterium longum, a bacterium related to F. prausnitzii, and tested the effects of these bacteria in an Apoe/− atherosclerosis mouse model. We show that administration of these three bacterial species to Apoe−/− mice robustly improves cardiac function, reduces plasma lipid levels, and attenuates the formation of atherosclerotic plaques. Comprehensive analysis of gut microbiota, plasma metabolome, and liver transcriptome revealed that the beneficial effects are associated with a modulation of the gut microbiota linked to a 7α-dehydroxylation–lithocholic acid (LCA)–farnesoid X receptor (FXR) pathway. Our study provides insights into transcriptional and metabolic impact whereby specific bacteria may hold promises for prevention/treatment of ACVD.",
keywords = "Bacteriology, Human metabolism, Microbial metabolism, Microbiology",
author = "Zhuye Jie and Qian Zhu and Yuanqiang Zou and Qili Wu and Min Qin and Dongdong He and Xiaoqian Lin and Xin Tong and Jiahao Zhang and Zhu Jie and Wenwei Luo and Xiao Xiao and Shiyu Chen and Yonglin Wu and Gongjie Guo and Shufen Zheng and Yong Li and Weihua Lai and Huanming Yang and Jian Wang and Liang Xiao and Jiyan Chen and Tao Zhang and Karsten Kristiansen and Huijue Jia and Shilong Zhong",
note = "Publisher Copyright: {\textcopyright} 2023",
year = "2023",
doi = "10.1016/j.isci.2023.106960",
language = "English",
volume = "26",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model

AU - Jie, Zhuye

AU - Zhu, Qian

AU - Zou, Yuanqiang

AU - Wu, Qili

AU - Qin, Min

AU - He, Dongdong

AU - Lin, Xiaoqian

AU - Tong, Xin

AU - Zhang, Jiahao

AU - Jie, Zhu

AU - Luo, Wenwei

AU - Xiao, Xiao

AU - Chen, Shiyu

AU - Wu, Yonglin

AU - Guo, Gongjie

AU - Zheng, Shufen

AU - Li, Yong

AU - Lai, Weihua

AU - Yang, Huanming

AU - Wang, Jian

AU - Xiao, Liang

AU - Chen, Jiyan

AU - Zhang, Tao

AU - Kristiansen, Karsten

AU - Jia, Huijue

AU - Zhong, Shilong

N1 - Publisher Copyright: © 2023

PY - 2023

Y1 - 2023

N2 - By a survey of metagenome-wide association studies (MWAS), we found a robust depletion of Bacteroides cellulosilyticus, Faecalibacterium prausnitzii, and Roseburia intestinalis in individuals with atherosclerotic cardiovascular disease (ACVD). From an established collection of bacteria isolated from healthy Chinese individuals, we selected B. cellulosilyticus, R. intestinalis, and Faecalibacterium longum, a bacterium related to F. prausnitzii, and tested the effects of these bacteria in an Apoe/− atherosclerosis mouse model. We show that administration of these three bacterial species to Apoe−/− mice robustly improves cardiac function, reduces plasma lipid levels, and attenuates the formation of atherosclerotic plaques. Comprehensive analysis of gut microbiota, plasma metabolome, and liver transcriptome revealed that the beneficial effects are associated with a modulation of the gut microbiota linked to a 7α-dehydroxylation–lithocholic acid (LCA)–farnesoid X receptor (FXR) pathway. Our study provides insights into transcriptional and metabolic impact whereby specific bacteria may hold promises for prevention/treatment of ACVD.

AB - By a survey of metagenome-wide association studies (MWAS), we found a robust depletion of Bacteroides cellulosilyticus, Faecalibacterium prausnitzii, and Roseburia intestinalis in individuals with atherosclerotic cardiovascular disease (ACVD). From an established collection of bacteria isolated from healthy Chinese individuals, we selected B. cellulosilyticus, R. intestinalis, and Faecalibacterium longum, a bacterium related to F. prausnitzii, and tested the effects of these bacteria in an Apoe/− atherosclerosis mouse model. We show that administration of these three bacterial species to Apoe−/− mice robustly improves cardiac function, reduces plasma lipid levels, and attenuates the formation of atherosclerotic plaques. Comprehensive analysis of gut microbiota, plasma metabolome, and liver transcriptome revealed that the beneficial effects are associated with a modulation of the gut microbiota linked to a 7α-dehydroxylation–lithocholic acid (LCA)–farnesoid X receptor (FXR) pathway. Our study provides insights into transcriptional and metabolic impact whereby specific bacteria may hold promises for prevention/treatment of ACVD.

KW - Bacteriology

KW - Human metabolism

KW - Microbial metabolism

KW - Microbiology

U2 - 10.1016/j.isci.2023.106960

DO - 10.1016/j.isci.2023.106960

M3 - Journal article

C2 - 37378328

AN - SCOPUS:85161545611

VL - 26

JO - iScience

JF - iScience

SN - 2589-0042

IS - 6

M1 - 106960

ER -

ID: 357066180