A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

Research output: Contribution to journalJournal articleResearchpeer-review


  • Lea Benedicte Skov Hansen
  • Nadja Buus Søndertoft
  • Rikke Juul Gøbel
  • Mette Bredal Kristensen
  • Mireia Vallès-Colomer
  • Sara Vieira-Silva
  • Sabine Ibrügger
  • Mads Vendelbo Lind
  • Rasmus Baadsgaard Mærkedahl
  • Martin Iain Bahl
  • Mia Linda Madsen
  • Jesper Havelund
  • Gwen Falony
  • Trine Nielsen
  • Kristine Højgaard Allin
  • Henrik Lund Frandsen
  • Morten H Sparholt
  • Jesper Holck
  • Janne Marie Moll
  • Anne S Meyer
  • Camilla Hoppe
  • Jørgen H Poulsen
  • Vera Carvalho
  • Domenico Sagnelli
  • Marlene Danner Dalgaard
  • Anders Fogh Christensen
  • Magnus Lydolph
  • Alistair B Ross
  • Silas G Villas-Bôas
  • Susanne Brix
  • Thomas Sicheritz-Pontén
  • Karsten Buschard
  • Jüri Johannes Rumessen
  • Christian Ritz
  • H Bjørn Nielsen
  • Nils J Færgeman
  • Jeroen Raes
  • Ramneek Gupta
  • Tine Rask Licht
Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.
Original languageEnglish
Article number4630
JournalNature Communications
Number of pages13
Publication statusPublished - 2018

Number of downloads are based on statistics from Google Scholar and www.ku.dk

No data available

ID: 208869531