A proximal promoter element required for positive transcriptional control by guanosine tetraphosphate and DKSA protein during the stringent response
Research output: Contribution to journal › Journal article › Research › peer-review
Background: ppGpp/DksA regulate genes both positively and negatively during stringency. Results: Positive control by ppGpp/DksA is linked to RNA polymerase-promoter saturation kinetics dependent on the promoter's discriminator. Conclusion: Promoters harboring discriminators that make them easily saturated with RNA polymerase are controlled positively by ppGpp/DksA. Significance: The discriminator is a cis-acting element dictating the response of the promoter to alterations in ppGpp/DksA and RNA polymerase availability.
| Original language | English |
|---|---|
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 29 |
| Pages (from-to) | 21055-21064 |
| Number of pages | 10 |
| ISSN | 0021-9258 |
| DOIs | |
| Publication status | Published - 19 Jul 2013 |
| Externally published | Yes |
ID: 165881718