Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea)

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea). / Christensen, Kathrine B; Petersen, Rasmus K; Petersen, Sidsel; Kristiansen, Karsten; Christensen, Lars P.

In: Journal of Natural Products, Vol. 72, No. 5, 2009, p. 933–937.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Christensen, KB, Petersen, RK, Petersen, S, Kristiansen, K & Christensen, LP 2009, 'Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea)', Journal of Natural Products, vol. 72, no. 5, pp. 933–937. https://doi.org/10.1021/np900003a

APA

Christensen, K. B., Petersen, R. K., Petersen, S., Kristiansen, K., & Christensen, L. P. (2009). Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea). Journal of Natural Products, 72(5), 933–937. https://doi.org/10.1021/np900003a

Vancouver

Christensen KB, Petersen RK, Petersen S, Kristiansen K, Christensen LP. Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea). Journal of Natural Products. 2009;72(5):933–937. https://doi.org/10.1021/np900003a

Author

Christensen, Kathrine B ; Petersen, Rasmus K ; Petersen, Sidsel ; Kristiansen, Karsten ; Christensen, Lars P. / Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea). In: Journal of Natural Products. 2009 ; Vol. 72, No. 5. pp. 933–937.

Bibtex

@article{7e34b59050e511de87b8000ea68e967b,
title = "Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea)",
abstract = "Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPARgamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPARgamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes.",
author = "Christensen, {Kathrine B} and Petersen, {Rasmus K} and Sidsel Petersen and Karsten Kristiansen and Christensen, {Lars P}",
year = "2009",
doi = "10.1021/np900003a",
language = "English",
volume = "72",
pages = "933–937",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "5",

}

RIS

TY - JOUR

T1 - Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea)

AU - Christensen, Kathrine B

AU - Petersen, Rasmus K

AU - Petersen, Sidsel

AU - Kristiansen, Karsten

AU - Christensen, Lars P

PY - 2009

Y1 - 2009

N2 - Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPARgamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPARgamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes.

AB - Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPARgamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPARgamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes.

U2 - 10.1021/np900003a

DO - 10.1021/np900003a

M3 - Journal article

C2 - 19374389

VL - 72

SP - 933

EP - 937

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 5

ER -

ID: 12491363