Age-dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging
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Age-dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging. / Sun, Liang; Li, Zhiming; Hu, Caiyou; Ding, Jiahong; Zhou, Qi; Pang, Guofang; Wu, Zhu; Yang, Ruiyue; Li, Shenghui; Li, Jian; Cai, Jianping; Sun, Yuzhe; Li, Rui; Zhen, Hefu; Sun, Shuqin; Zhang, Jianmin; Fang, Mingyan; Chen, Zhihua; Lv, Yuan; Cao, Qizhi; Sun, Yanan; Gong, Ranhui; Huang, Zezhi; Duan, Yong; Liu, Hengshuo; Dong, Jun; Li, Junchun; Ruan, Jie; Lu, Haorong; He, Benjin; Li, Ninghu; Li, Tao; Xue, Wenbin; Li, Yan; Shen, Juan; Yang, Fan; Zhao, Cheng; Liang, Qinghua; Zhang, Mingrong; Chen, Chen; Gong, Huan; Hou, Yong; Wang, Jian; Zhang, Ying; Yang, Huanming; Zhu, Shida; Xiao, Liang; Jin, Zhen; Guo, Haiyun; Zhao, Peng; Brix, Susanne; Xu, Xun; Jia, Huijue; Kristiansen, Karsten; Yang, Ze; Nie, Chao.
In: Aging Cell, Vol. 22, No. 12, e14028, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Age-dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging
AU - Sun, Liang
AU - Li, Zhiming
AU - Hu, Caiyou
AU - Ding, Jiahong
AU - Zhou, Qi
AU - Pang, Guofang
AU - Wu, Zhu
AU - Yang, Ruiyue
AU - Li, Shenghui
AU - Li, Jian
AU - Cai, Jianping
AU - Sun, Yuzhe
AU - Li, Rui
AU - Zhen, Hefu
AU - Sun, Shuqin
AU - Zhang, Jianmin
AU - Fang, Mingyan
AU - Chen, Zhihua
AU - Lv, Yuan
AU - Cao, Qizhi
AU - Sun, Yanan
AU - Gong, Ranhui
AU - Huang, Zezhi
AU - Duan, Yong
AU - Liu, Hengshuo
AU - Dong, Jun
AU - Li, Junchun
AU - Ruan, Jie
AU - Lu, Haorong
AU - He, Benjin
AU - Li, Ninghu
AU - Li, Tao
AU - Xue, Wenbin
AU - Li, Yan
AU - Shen, Juan
AU - Yang, Fan
AU - Zhao, Cheng
AU - Liang, Qinghua
AU - Zhang, Mingrong
AU - Chen, Chen
AU - Gong, Huan
AU - Hou, Yong
AU - Wang, Jian
AU - Zhang, Ying
AU - Yang, Huanming
AU - Zhu, Shida
AU - Xiao, Liang
AU - Jin, Zhen
AU - Guo, Haiyun
AU - Zhao, Peng
AU - Brix, Susanne
AU - Xu, Xun
AU - Jia, Huijue
AU - Kristiansen, Karsten
AU - Yang, Ze
AU - Nie, Chao
N1 - Publisher Copyright: © 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Human aging is invariably accompanied by a decline in renal function, a process potentially exacerbated by uremic toxins originating from gut microbes. Based on a registered household Chinese Guangxi longevity cohort (n = 151), we conducted comprehensive profiling of the gut microbiota and serum metabolome of individuals from 22 to 111 years of age and validated the findings in two independent East Asian aging cohorts (Japan aging cohort n = 330, Yunnan aging cohort n = 80), identifying unique age-dependent differences in the microbiota and serum metabolome. We discovered that the influence of the gut microbiota on serum metabolites intensifies with advancing age. Furthermore, mediation analyses unveiled putative causal relationships between the gut microbiota (Escherichia coli, Odoribacter splanchnicus, and Desulfovibrio piger) and serum metabolite markers related to impaired renal function (p-cresol, N-phenylacetylglutamine, 2-oxindole, and 4-aminohippuric acid) and aging. The fecal microbiota transplantation experiment demonstrated that the feces of elderly individuals could influence markers related to impaired renal function in the serum. Our findings reveal novel links between age-dependent alterations in the gut microbiota and serum metabolite markers of impaired renal function, providing novel insights into the effects of microbiota-metabolite interplay on renal function and healthy aging.
AB - Human aging is invariably accompanied by a decline in renal function, a process potentially exacerbated by uremic toxins originating from gut microbes. Based on a registered household Chinese Guangxi longevity cohort (n = 151), we conducted comprehensive profiling of the gut microbiota and serum metabolome of individuals from 22 to 111 years of age and validated the findings in two independent East Asian aging cohorts (Japan aging cohort n = 330, Yunnan aging cohort n = 80), identifying unique age-dependent differences in the microbiota and serum metabolome. We discovered that the influence of the gut microbiota on serum metabolites intensifies with advancing age. Furthermore, mediation analyses unveiled putative causal relationships between the gut microbiota (Escherichia coli, Odoribacter splanchnicus, and Desulfovibrio piger) and serum metabolite markers related to impaired renal function (p-cresol, N-phenylacetylglutamine, 2-oxindole, and 4-aminohippuric acid) and aging. The fecal microbiota transplantation experiment demonstrated that the feces of elderly individuals could influence markers related to impaired renal function in the serum. Our findings reveal novel links between age-dependent alterations in the gut microbiota and serum metabolite markers of impaired renal function, providing novel insights into the effects of microbiota-metabolite interplay on renal function and healthy aging.
KW - aging
KW - gut microbiota
KW - renal function
KW - serum metabolome
U2 - 10.1111/acel.14028
DO - 10.1111/acel.14028
M3 - Journal article
C2 - 38015106
AN - SCOPUS:85177775152
VL - 22
JO - Aging Cell
JF - Aging Cell
SN - 1474-9718
IS - 12
M1 - e14028
ER -
ID: 375206577