Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan
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Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan. / Johansen, Joachim; Atarashi, Koji; Arai, Yasumichi; Hirose, Nobuyoshi; Sørensen, Søren J.; Vatanen, Tommi; Knip, Mikael; Honda, Kenya; Xavier, Ramnik J.; Rasmussen, Simon; Plichta, Damian R.
In: Nature Microbiology, Vol. 8, 2023, p. 1064-1078.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan
AU - Johansen, Joachim
AU - Atarashi, Koji
AU - Arai, Yasumichi
AU - Hirose, Nobuyoshi
AU - Sørensen, Søren J.
AU - Vatanen, Tommi
AU - Knip, Mikael
AU - Honda, Kenya
AU - Xavier, Ramnik J.
AU - Rasmussen, Simon
AU - Plichta, Damian R.
PY - 2023
Y1 - 2023
N2 - Distinct gut microbiome ecology may be implicated in the prevention of aging-related diseases as it influences systemic immune function and resistance to infections. Yet, the viral component of the microbiome throughout different stages in life remains unexplored. Here we present a characterization of the centenarian gut virome using previously published metagenomes from 195 individuals from Japan and Sardinia. Compared with gut viromes of younger adults (>18 yr) and older individuals (>60 yr), centenarians had a more diverse virome including previously undescribed viral genera, such as viruses associated with Clostridia. A population shift towards higher lytic activity was also observed. Finally, we investigated phage-encoded auxiliary functions that influence bacterial physiology, which revealed an enrichment of genes supporting key steps in sulfate metabolic pathways. Phage and bacterial members of the centenarian microbiome displayed an increased potential for converting methionine to homocysteine, sulfate to sulfide and taurine to sulfide. A greater metabolic output of microbial hydrogen sulfide in centenarians may in turn support mucosal integrity and resistance to pathobionts.Centenarians have a diverse population of gut bacteriophages, a subset of which encode sulfate metabolism genes and may promote healthy aging.
AB - Distinct gut microbiome ecology may be implicated in the prevention of aging-related diseases as it influences systemic immune function and resistance to infections. Yet, the viral component of the microbiome throughout different stages in life remains unexplored. Here we present a characterization of the centenarian gut virome using previously published metagenomes from 195 individuals from Japan and Sardinia. Compared with gut viromes of younger adults (>18 yr) and older individuals (>60 yr), centenarians had a more diverse virome including previously undescribed viral genera, such as viruses associated with Clostridia. A population shift towards higher lytic activity was also observed. Finally, we investigated phage-encoded auxiliary functions that influence bacterial physiology, which revealed an enrichment of genes supporting key steps in sulfate metabolic pathways. Phage and bacterial members of the centenarian microbiome displayed an increased potential for converting methionine to homocysteine, sulfate to sulfide and taurine to sulfide. A greater metabolic output of microbial hydrogen sulfide in centenarians may in turn support mucosal integrity and resistance to pathobionts.Centenarians have a diverse population of gut bacteriophages, a subset of which encode sulfate metabolism genes and may promote healthy aging.
KW - ALIGNMENT
KW - BACTERIOPHAGES
KW - MICROBIOME
KW - SEQUENCE
U2 - 10.1038/s41564-023-01370-6
DO - 10.1038/s41564-023-01370-6
M3 - Journal article
C2 - 37188814
VL - 8
SP - 1064
EP - 1078
JO - Nature Microbiology
JF - Nature Microbiology
SN - 2058-5276
ER -
ID: 347887023