Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity

Research output: Contribution to journal › Journal article › Research › peer-review

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Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity. / Zhang, Guojie; Cowled, Christopher; Shi, Zhengli; Huang, Zhiyong; Bishop-Lilly, Kimberly A.; Fang, Xiaodong; Wynne, James W.; Xiong, Zhiqiang; Baker, Michelle L.; Zhao, Wei; Tachedjian, Mary; Zhu, Yabing; Zhou, Peng; Jiang, Xuanting; Ng, Justin; Yang, Lan; Wu, Lijun; Xiao, Jin; Feng, Yue; Chen, Yuanxin; Sun, Xiaoqing; Zhang, Yong; Marsh, Glenn A.; Crameri, Gary; Broder, Christopher C.; Frey, Kenneth G.; Wang, Lin-Fa; Wang, Jun.

In: Science (New York, N.Y.), Vol. 339, No. 6118, 2013.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhang, G, Cowled, C, Shi, Z, Huang, Z, Bishop-Lilly, KA, Fang, X, Wynne, JW, Xiong, Z, Baker, ML, Zhao, W, Tachedjian, M, Zhu, Y, Zhou, P, Jiang, X, Ng, J, Yang, L, Wu, L, Xiao, J, Feng, Y, Chen, Y, Sun, X, Zhang, Y, Marsh, GA, Crameri, G, Broder, CC, Frey, KG, Wang, L-F & Wang, J 2013, 'Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity', Science (New York, N.Y.), vol. 339, no. 6118. https://doi.org/10.1126/science.1230835

APA

Zhang, G., Cowled, C., Shi, Z., Huang, Z., Bishop-Lilly, K. A., Fang, X., Wynne, J. W., Xiong, Z., Baker, M. L., Zhao, W., Tachedjian, M., Zhu, Y., Zhou, P., Jiang, X., Ng, J., Yang, L., Wu, L., Xiao, J., Feng, Y., ... Wang, J. (2013). Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity. Science (New York, N.Y.), 339(6118). https://doi.org/10.1126/science.1230835

Vancouver

Zhang G, Cowled C, Shi Z, Huang Z, Bishop-Lilly KA, Fang X et al. Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity. Science (New York, N.Y.). 2013;339(6118). https://doi.org/10.1126/science.1230835

Author

Zhang, Guojie ; Cowled, Christopher ; Shi, Zhengli ; Huang, Zhiyong ; Bishop-Lilly, Kimberly A. ; Fang, Xiaodong ; Wynne, James W. ; Xiong, Zhiqiang ; Baker, Michelle L. ; Zhao, Wei ; Tachedjian, Mary ; Zhu, Yabing ; Zhou, Peng ; Jiang, Xuanting ; Ng, Justin ; Yang, Lan ; Wu, Lijun ; Xiao, Jin ; Feng, Yue ; Chen, Yuanxin ; Sun, Xiaoqing ; Zhang, Yong ; Marsh, Glenn A. ; Crameri, Gary ; Broder, Christopher C. ; Frey, Kenneth G. ; Wang, Lin-Fa ; Wang, Jun. / Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity. In: Science (New York, N.Y.). 2013 ; Vol. 339, No. 6118.

Bibtex

@article{0ffdf3ab80ff41969e70df6f0db0deda,
title = "Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity",
abstract = "Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropus alecto and insectivorous Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor-¿B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.",
author = "Guojie Zhang and Christopher Cowled and Zhengli Shi and Zhiyong Huang and Bishop-Lilly, {Kimberly A.} and Xiaodong Fang and Wynne, {James W.} and Zhiqiang Xiong and Baker, {Michelle L.} and Wei Zhao and Mary Tachedjian and Yabing Zhu and Peng Zhou and Xuanting Jiang and Justin Ng and Lan Yang and Lijun Wu and Jin Xiao and Yue Feng and Yuanxin Chen and Xiaoqing Sun and Yong Zhang and Marsh, {Glenn A.} and Gary Crameri and Broder, {Christopher C.} and Frey, {Kenneth G.} and Lin-Fa Wang and Jun Wang",
year = "2013",
doi = "10.1126/science.1230835",
language = "English",
volume = "339",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6118",

}

RIS

TY - JOUR

T1 - Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity

AU - Zhang, Guojie

AU - Cowled, Christopher

AU - Shi, Zhengli

AU - Huang, Zhiyong

AU - Bishop-Lilly, Kimberly A.

AU - Fang, Xiaodong

AU - Wynne, James W.

AU - Xiong, Zhiqiang

AU - Baker, Michelle L.

AU - Zhao, Wei

AU - Tachedjian, Mary

AU - Zhu, Yabing

AU - Zhou, Peng

AU - Jiang, Xuanting

AU - Ng, Justin

AU - Yang, Lan

AU - Wu, Lijun

AU - Xiao, Jin

AU - Feng, Yue

AU - Chen, Yuanxin

AU - Sun, Xiaoqing

AU - Zhang, Yong

AU - Marsh, Glenn A.

AU - Crameri, Gary

AU - Broder, Christopher C.

AU - Frey, Kenneth G.

AU - Wang, Lin-Fa

AU - Wang, Jun

PY - 2013

Y1 - 2013

N2 - Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropus alecto and insectivorous Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor-¿B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.

AB - Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropus alecto and insectivorous Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor-¿B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.

U2 - 10.1126/science.1230835

DO - 10.1126/science.1230835

M3 - Journal article

C2 - 23258410

VL - 339

JO - Science

JF - Science

SN - 0036-8075

IS - 6118

ER -

ID: 43544019