Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma. / Stokholm, Jakob; Thorsen, Jonathan; Blaser, Martin J; Rasmussen, Morten A.; Hjelmsø, Mathis; Shah, Shiraz; Christensen, Emil D.; Chawes, Bo L.; Bønnelykke, Klaus; Brix, Susanne; Mortensen, Martin S.; Brejnrod, Asker; Vestergaard, Gisle; Trivedi, Urvish; Sørensen, Søren J.; Bisgaard, Hans.

In: Science Translational Medicine, Vol. 12, No. 569, eaax9929, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stokholm, J, Thorsen, J, Blaser, MJ, Rasmussen, MA, Hjelmsø, M, Shah, S, Christensen, ED, Chawes, BL, Bønnelykke, K, Brix, S, Mortensen, MS, Brejnrod, A, Vestergaard, G, Trivedi, U, Sørensen, SJ & Bisgaard, H 2020, 'Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma', Science Translational Medicine, vol. 12, no. 569, eaax9929. https://doi.org/10.1126/scitranslmed.aax9929

APA

Stokholm, J., Thorsen, J., Blaser, M. J., Rasmussen, M. A., Hjelmsø, M., Shah, S., Christensen, E. D., Chawes, B. L., Bønnelykke, K., Brix, S., Mortensen, M. S., Brejnrod, A., Vestergaard, G., Trivedi, U., Sørensen, S. J., & Bisgaard, H. (2020). Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma. Science Translational Medicine, 12(569), [eaax9929]. https://doi.org/10.1126/scitranslmed.aax9929

Vancouver

Stokholm J, Thorsen J, Blaser MJ, Rasmussen MA, Hjelmsø M, Shah S et al. Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma. Science Translational Medicine. 2020;12(569). eaax9929. https://doi.org/10.1126/scitranslmed.aax9929

Author

Stokholm, Jakob ; Thorsen, Jonathan ; Blaser, Martin J ; Rasmussen, Morten A. ; Hjelmsø, Mathis ; Shah, Shiraz ; Christensen, Emil D. ; Chawes, Bo L. ; Bønnelykke, Klaus ; Brix, Susanne ; Mortensen, Martin S. ; Brejnrod, Asker ; Vestergaard, Gisle ; Trivedi, Urvish ; Sørensen, Søren J. ; Bisgaard, Hans. / Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma. In: Science Translational Medicine. 2020 ; Vol. 12, No. 569.

Bibtex

@article{2156055ea0ad4d5b8e2d722e665a876e,
title = "Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma",
abstract = "There have been reports of associations between cesarean section delivery and the risk of childhood asthma, potentially mediated through changes in the gut microbiota. We followed 700 children in the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) cohort prospectively from birth. We examined the effects of cesarean section delivery on gut microbial composition by 16S rRNA gene amplicon sequencing during the first year of life. We then explored whether gut microbial perturbations due to delivery mode were associated with a risk of developing asthma in the first 6 years of life. Delivery by cesarean section was accompanied by marked changes in gut microbiota composition at one week and one month of age, but by one year of age only minor differences persisted compared to vaginal delivery. Increased asthma risk was found in children born by cesarean section only if their gut microbiota composition at 1 year of age still retained a cesarean section microbial signature, suggesting that appropriate maturation of the gut microbiota could mitigate against the increased asthma risk associated with gut microbial changes due to cesarean section delivery.",
author = "Jakob Stokholm and Jonathan Thorsen and Blaser, {Martin J} and Rasmussen, {Morten A.} and Mathis Hjelms{\o} and Shiraz Shah and Christensen, {Emil D.} and Chawes, {Bo L.} and Klaus B{\o}nnelykke and Susanne Brix and Mortensen, {Martin S.} and Asker Brejnrod and Gisle Vestergaard and Urvish Trivedi and S{\o}rensen, {S{\o}ren J.} and Hans Bisgaard",
note = "Copyright {\textcopyright} 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",
year = "2020",
doi = "10.1126/scitranslmed.aax9929",
language = "English",
volume = "12",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "american association for the advancement of science",
number = "569",

}

RIS

TY - JOUR

T1 - Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

AU - Stokholm, Jakob

AU - Thorsen, Jonathan

AU - Blaser, Martin J

AU - Rasmussen, Morten A.

AU - Hjelmsø, Mathis

AU - Shah, Shiraz

AU - Christensen, Emil D.

AU - Chawes, Bo L.

AU - Bønnelykke, Klaus

AU - Brix, Susanne

AU - Mortensen, Martin S.

AU - Brejnrod, Asker

AU - Vestergaard, Gisle

AU - Trivedi, Urvish

AU - Sørensen, Søren J.

AU - Bisgaard, Hans

N1 - Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

PY - 2020

Y1 - 2020

N2 - There have been reports of associations between cesarean section delivery and the risk of childhood asthma, potentially mediated through changes in the gut microbiota. We followed 700 children in the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) cohort prospectively from birth. We examined the effects of cesarean section delivery on gut microbial composition by 16S rRNA gene amplicon sequencing during the first year of life. We then explored whether gut microbial perturbations due to delivery mode were associated with a risk of developing asthma in the first 6 years of life. Delivery by cesarean section was accompanied by marked changes in gut microbiota composition at one week and one month of age, but by one year of age only minor differences persisted compared to vaginal delivery. Increased asthma risk was found in children born by cesarean section only if their gut microbiota composition at 1 year of age still retained a cesarean section microbial signature, suggesting that appropriate maturation of the gut microbiota could mitigate against the increased asthma risk associated with gut microbial changes due to cesarean section delivery.

AB - There have been reports of associations between cesarean section delivery and the risk of childhood asthma, potentially mediated through changes in the gut microbiota. We followed 700 children in the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) cohort prospectively from birth. We examined the effects of cesarean section delivery on gut microbial composition by 16S rRNA gene amplicon sequencing during the first year of life. We then explored whether gut microbial perturbations due to delivery mode were associated with a risk of developing asthma in the first 6 years of life. Delivery by cesarean section was accompanied by marked changes in gut microbiota composition at one week and one month of age, but by one year of age only minor differences persisted compared to vaginal delivery. Increased asthma risk was found in children born by cesarean section only if their gut microbiota composition at 1 year of age still retained a cesarean section microbial signature, suggesting that appropriate maturation of the gut microbiota could mitigate against the increased asthma risk associated with gut microbial changes due to cesarean section delivery.

U2 - 10.1126/scitranslmed.aax9929

DO - 10.1126/scitranslmed.aax9929

M3 - Journal article

C2 - 33177184

VL - 12

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 569

M1 - eaax9929

ER -

ID: 251413972