Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis
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Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis. / Oh, Dong-Chan; Poulsen, Michael; Currie, Cameron R; Clardy, Jon.
In: Nature Chemical Biology, Vol. 5, No. 6, 01.06.2009, p. 391-3.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis
AU - Oh, Dong-Chan
AU - Poulsen, Michael
AU - Currie, Cameron R
AU - Clardy, Jon
PY - 2009/6/1
Y1 - 2009/6/1
N2 - Fungus-growing ants engage in mutualistic associations with both the fungus they cultivate for food and actinobacteria (Pseudonocardia spp.) that produce selective antibiotics to defend that fungus from specialized fungal parasites. We have analyzed one such system at the molecular level and found that the bacterium associated with the ant Apterostigma dentigerum produces dentigerumycin, a cyclic depsipeptide with highly modified amino acids, to selectively inhibit the associated parasitic fungus (Escovopsis sp.).
AB - Fungus-growing ants engage in mutualistic associations with both the fungus they cultivate for food and actinobacteria (Pseudonocardia spp.) that produce selective antibiotics to defend that fungus from specialized fungal parasites. We have analyzed one such system at the molecular level and found that the bacterium associated with the ant Apterostigma dentigerum produces dentigerumycin, a cyclic depsipeptide with highly modified amino acids, to selectively inhibit the associated parasitic fungus (Escovopsis sp.).
KW - Animals
KW - Ants
KW - Bacterial Physiological Phenomena
KW - Chromatography, High Pressure Liquid
KW - Fungi
KW - Magnetic Resonance Spectroscopy
KW - Peptides, Cyclic
KW - Spectrometry, Mass, Electrospray Ionization
KW - Symbiosis
U2 - 10.1038/nchembio.159
DO - 10.1038/nchembio.159
M3 - Journal article
C2 - 19330011
VL - 5
SP - 391
EP - 393
JO - Nature Chemical Biology
JF - Nature Chemical Biology
SN - 1552-4450
IS - 6
ER -
ID: 33079688