Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults
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Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults. / Li, Xuanji; Brejnrod, Asker; Thorsen, Jonathan; Zachariasen, Trine; Trivedi, Urvish; Russel, Jakob; Vestergaard, Gisle Alberg; Stokholm, Jakob; Rasmussen, Morten Arendt; Sørensen, Søren Johannes.
In: Nature Communications, Vol. 14, No. 1, 8526, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults
AU - Li, Xuanji
AU - Brejnrod, Asker
AU - Thorsen, Jonathan
AU - Zachariasen, Trine
AU - Trivedi, Urvish
AU - Russel, Jakob
AU - Vestergaard, Gisle Alberg
AU - Stokholm, Jakob
AU - Rasmussen, Morten Arendt
AU - Sørensen, Søren Johannes
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Despite their crucial importance for human health, there is still relatively limited knowledge on how the gut resistome changes or responds to antibiotic treatment across ages, especially in the latter case. Here, we use fecal metagenomic data from 662 Danish infants and 217 young adults to fill this gap. The gut resistomes are characterized by a bimodal distribution driven by E. coli composition. The typical profile of the gut resistome differs significantly between adults and infants, with the latter distinguished by higher gene and plasmid abundances. However, the predominant antibiotic resistance genes (ARGs) are the same. Antibiotic treatment reduces bacterial diversity and increased ARG and plasmid abundances in both cohorts, especially core ARGs. The effects of antibiotic treatments on the gut microbiome last longer in adults than in infants, and different antibiotics are associated with distinct impacts. Overall, this study broadens our current understanding of gut resistome dynamics and the impact of antibiotic treatment across age groups.
AB - Despite their crucial importance for human health, there is still relatively limited knowledge on how the gut resistome changes or responds to antibiotic treatment across ages, especially in the latter case. Here, we use fecal metagenomic data from 662 Danish infants and 217 young adults to fill this gap. The gut resistomes are characterized by a bimodal distribution driven by E. coli composition. The typical profile of the gut resistome differs significantly between adults and infants, with the latter distinguished by higher gene and plasmid abundances. However, the predominant antibiotic resistance genes (ARGs) are the same. Antibiotic treatment reduces bacterial diversity and increased ARG and plasmid abundances in both cohorts, especially core ARGs. The effects of antibiotic treatments on the gut microbiome last longer in adults than in infants, and different antibiotics are associated with distinct impacts. Overall, this study broadens our current understanding of gut resistome dynamics and the impact of antibiotic treatment across age groups.
U2 - 10.1038/s41467-023-44289-6
DO - 10.1038/s41467-023-44289-6
M3 - Journal article
C2 - 38135681
AN - SCOPUS:85180464207
VL - 14
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 8526
ER -
ID: 377989747