Early life factors and oral microbial signatures define the risk of caries in a Swedish cohort of preschool children
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Early life factors and oral microbial signatures define the risk of caries in a Swedish cohort of preschool children. / Eriksen, Carsten; Boustedt, Katarina; Sonne, Si Brask; Dahlgren, Jovanna; Kristiansen, Karsten; Twetman, Svante; Brix, Susanne; Roswall, Josefine.
In: Scientific Reports, Vol. 14, No. 1, 8463, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Early life factors and oral microbial signatures define the risk of caries in a Swedish cohort of preschool children
AU - Eriksen, Carsten
AU - Boustedt, Katarina
AU - Sonne, Si Brask
AU - Dahlgren, Jovanna
AU - Kristiansen, Karsten
AU - Twetman, Svante
AU - Brix, Susanne
AU - Roswall, Josefine
N1 - Publisher Copyright: © The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - The oral cavity harbors complex communities comprising bacteria, archaea, fungi, protozoa, and viruses. The oral microbiota is establish at birth and develops further during childhood, with early life factors such as birth mode, feeding practices, and oral hygiene, reported to influence this development and the susceptibility to caries. We here analyzed the oral bacterial composition in saliva of 260 Swedish children at two, three and five years of age using 16S rRNA gene profiling to examine its relation to environmental factors and caries development at five years of age. We were able to assign the salivary bacterial community in each child at each time point to one of seven distinct clusters. We observed an individual dynamic in the development of the oral microbiota related to early life factors, such as being first born, born by C-section, maternal perinatal antibiotics use, with a distinct transition between three and five years of age. Different bacterial signatures depending on age were related to increased caries risk, while Peptococcus consistently linked to reduced risk of caries development.
AB - The oral cavity harbors complex communities comprising bacteria, archaea, fungi, protozoa, and viruses. The oral microbiota is establish at birth and develops further during childhood, with early life factors such as birth mode, feeding practices, and oral hygiene, reported to influence this development and the susceptibility to caries. We here analyzed the oral bacterial composition in saliva of 260 Swedish children at two, three and five years of age using 16S rRNA gene profiling to examine its relation to environmental factors and caries development at five years of age. We were able to assign the salivary bacterial community in each child at each time point to one of seven distinct clusters. We observed an individual dynamic in the development of the oral microbiota related to early life factors, such as being first born, born by C-section, maternal perinatal antibiotics use, with a distinct transition between three and five years of age. Different bacterial signatures depending on age were related to increased caries risk, while Peptococcus consistently linked to reduced risk of caries development.
U2 - 10.1038/s41598-024-59126-z
DO - 10.1038/s41598-024-59126-z
M3 - Journal article
C2 - 38605085
AN - SCOPUS:85189947949
VL - 14
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 8463
ER -
ID: 388829580