Emerging roles of the CIP2A–TopBP1 complex in genome integrity

Research output: Contribution to journal › Journal article › Research › peer-review

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Emerging roles of the CIP2A–TopBP1 complex in genome integrity. / Ummethum, Henning; Li, Jiayi; Lisby, Michael; Oestergaard, Vibe H.

In: NAR Cancer, Vol. 5, No. 4, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ummethum, H, Li, J, Lisby, M & Oestergaard, VH 2023, 'Emerging roles of the CIP2A–TopBP1 complex in genome integrity', NAR Cancer, vol. 5, no. 4. https://doi.org/10.1093/narcan/zcad052

APA

Ummethum, H., Li, J., Lisby, M., & Oestergaard, VH. (2023). Emerging roles of the CIP2A–TopBP1 complex in genome integrity. NAR Cancer, 5(4). https://doi.org/10.1093/narcan/zcad052

Vancouver

Ummethum H, Li J, Lisby M, Oestergaard VH. Emerging roles of the CIP2A–TopBP1 complex in genome integrity. NAR Cancer. 2023;5(4). https://doi.org/10.1093/narcan/zcad052

Author

Ummethum, Henning ; Li, Jiayi ; Lisby, Michael ; Oestergaard, Vibe H. / Emerging roles of the CIP2A–TopBP1 complex in genome integrity. In: NAR Cancer. 2023 ; Vol. 5, No. 4.

Bibtex

@article{492755e15ef942df84a72e30e0512fd6,
title = "Emerging roles of the CIP2A–TopBP1 complex in genome integrity",
abstract = "CIP2A is an inhibitor of the tumour suppressor protein phosphatase 2A. Recently, CIP2A was identified as a synthetic lethal interactor of BRCA1 and BRCA2 and a driver of basal-like breast cancers. In addition, a joint role of TopBP1 (topoisomerase IIβ-binding protein 1) and CIP2A for maintaining genome integrity during mitosis was discovered. TopBP1 has multiple functions as it is a scaffold for proteins involved in DNA replication, transcriptional regulation, cell cycle regulation and DNA repair. Here, we briefly review details of the CIP2A–TopBP1 interaction, its role in maintaining genome integrity, its involvement in cancer and its potential as a therapeutic target.",
author = "Henning Ummethum and Jiayi Li and Michael Lisby and Vibe H Oestergaard",
year = "2023",
doi = "10.1093/narcan/zcad052",
language = "English",
volume = "5",
journal = "NAR Cancer",
issn = "2632-8674",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Emerging roles of the CIP2A–TopBP1 complex in genome integrity

AU - Ummethum, Henning

AU - Li, Jiayi

AU - Lisby, Michael

AU - Oestergaard, Vibe H

PY - 2023

Y1 - 2023

N2 - CIP2A is an inhibitor of the tumour suppressor protein phosphatase 2A. Recently, CIP2A was identified as a synthetic lethal interactor of BRCA1 and BRCA2 and a driver of basal-like breast cancers. In addition, a joint role of TopBP1 (topoisomerase IIβ-binding protein 1) and CIP2A for maintaining genome integrity during mitosis was discovered. TopBP1 has multiple functions as it is a scaffold for proteins involved in DNA replication, transcriptional regulation, cell cycle regulation and DNA repair. Here, we briefly review details of the CIP2A–TopBP1 interaction, its role in maintaining genome integrity, its involvement in cancer and its potential as a therapeutic target.

AB - CIP2A is an inhibitor of the tumour suppressor protein phosphatase 2A. Recently, CIP2A was identified as a synthetic lethal interactor of BRCA1 and BRCA2 and a driver of basal-like breast cancers. In addition, a joint role of TopBP1 (topoisomerase IIβ-binding protein 1) and CIP2A for maintaining genome integrity during mitosis was discovered. TopBP1 has multiple functions as it is a scaffold for proteins involved in DNA replication, transcriptional regulation, cell cycle regulation and DNA repair. Here, we briefly review details of the CIP2A–TopBP1 interaction, its role in maintaining genome integrity, its involvement in cancer and its potential as a therapeutic target.

U2 - 10.1093/narcan/zcad052

DO - 10.1093/narcan/zcad052

M3 - Journal article

C2 - 37829116

VL - 5

JO - NAR Cancer

JF - NAR Cancer

SN - 2632-8674

IS - 4

ER -

ID: 371019402