Extrachromosomal circular DNA in cancer: history, current knowledge, and methods

Research output: Contribution to journal › Review › Research › peer-review

Standard

Extrachromosomal circular DNA in cancer : history, current knowledge, and methods. / Noer, Julie B.; Hørsdal, Oskar K.; Xiang, Xi; Luo, Yonglun; Regenberg, Birgitte.

In: Trends in Genetics, Vol. 38, No. 7, 2022, p. 766-781.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Noer, JB, Hørsdal, OK, Xiang, X, Luo, Y & Regenberg, B 2022, 'Extrachromosomal circular DNA in cancer: history, current knowledge, and methods', Trends in Genetics, vol. 38, no. 7, pp. 766-781. https://doi.org/10.1016/j.tig.2022.02.007

APA

Noer, J. B., Hørsdal, O. K., Xiang, X., Luo, Y., & Regenberg, B. (2022). Extrachromosomal circular DNA in cancer: history, current knowledge, and methods. Trends in Genetics, 38(7), 766-781. https://doi.org/10.1016/j.tig.2022.02.007

Vancouver

Noer JB, Hørsdal OK, Xiang X, Luo Y, Regenberg B. Extrachromosomal circular DNA in cancer: history, current knowledge, and methods. Trends in Genetics. 2022;38(7):766-781. https://doi.org/10.1016/j.tig.2022.02.007

Author

Noer, Julie B. ; Hørsdal, Oskar K. ; Xiang, Xi ; Luo, Yonglun ; Regenberg, Birgitte. / Extrachromosomal circular DNA in cancer : history, current knowledge, and methods. In: Trends in Genetics. 2022 ; Vol. 38, No. 7. pp. 766-781.

Bibtex

@article{010707f771d4410f86105f630ae5e612,
title = "Extrachromosomal circular DNA in cancer: history, current knowledge, and methods",
abstract = "Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA molecule found in all tested eukaryotes. eccDNA plays important roles in cancer pathogenesis, evolution of tumor heterogeneity, and therapeutic resistance. It is known under many names, including very large cancer-specific circular extrachromosomal DNA (ecDNA), which carries oncogenes and is often amplified in cancer cells. Our understanding of eccDNA has historically been limited and fragmented. To provide better a context of new and previous research on eccDNA, in this review we give an overview of the various names given to eccDNA at different times. We describe the different mechanisms for formation of eccDNA and the methods used to study eccDNA thus far. Finally, we explore the potential clinical value of eccDNA.",
keywords = "copy number variation, DNA damage, double minutes, eccDNA, ecDNA, oncogene amplification",
author = "Noer, {Julie B.} and H{\o}rsdal, {Oskar K.} and Xi Xiang and Yonglun Luo and Birgitte Regenberg",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
doi = "10.1016/j.tig.2022.02.007",
language = "English",
volume = "38",
pages = "766--781",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Ltd. * Trends Journals",
number = "7",

}

RIS

TY - JOUR

T1 - Extrachromosomal circular DNA in cancer

T2 - history, current knowledge, and methods

AU - Noer, Julie B.

AU - Hørsdal, Oskar K.

AU - Xiang, Xi

AU - Luo, Yonglun

AU - Regenberg, Birgitte

N1 - Publisher Copyright: © 2022 The Authors

PY - 2022

Y1 - 2022

N2 - Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA molecule found in all tested eukaryotes. eccDNA plays important roles in cancer pathogenesis, evolution of tumor heterogeneity, and therapeutic resistance. It is known under many names, including very large cancer-specific circular extrachromosomal DNA (ecDNA), which carries oncogenes and is often amplified in cancer cells. Our understanding of eccDNA has historically been limited and fragmented. To provide better a context of new and previous research on eccDNA, in this review we give an overview of the various names given to eccDNA at different times. We describe the different mechanisms for formation of eccDNA and the methods used to study eccDNA thus far. Finally, we explore the potential clinical value of eccDNA.

AB - Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA molecule found in all tested eukaryotes. eccDNA plays important roles in cancer pathogenesis, evolution of tumor heterogeneity, and therapeutic resistance. It is known under many names, including very large cancer-specific circular extrachromosomal DNA (ecDNA), which carries oncogenes and is often amplified in cancer cells. Our understanding of eccDNA has historically been limited and fragmented. To provide better a context of new and previous research on eccDNA, in this review we give an overview of the various names given to eccDNA at different times. We describe the different mechanisms for formation of eccDNA and the methods used to study eccDNA thus far. Finally, we explore the potential clinical value of eccDNA.

KW - copy number variation

KW - DNA damage

KW - double minutes

KW - eccDNA

KW - ecDNA

KW - oncogene amplification

U2 - 10.1016/j.tig.2022.02.007

DO - 10.1016/j.tig.2022.02.007

M3 - Review

C2 - 35277298

AN - SCOPUS:85125901233

VL - 38

SP - 766

EP - 781

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 7

ER -

ID: 304021853