Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas. / Wu, Kui; Zhang, Xin; Li, Fuqiang; Xiao, Dakai; Hou, Yong; Zhu, Shida; Liu, Dongbing; Ye, Xiaofei; Ye, Mingzhi; Yang, Jie; Shao, Libin; Pan, Hui; Lu, Na; Yu, Yuan; Liu, Liping; Li, Jin; Huang, Liyan; Tang, Hailing; Deng, Qiuhua; Zheng, Yue; Peng, Lihua; Liu, Geng; Gu, Xia; He, Ping; Gu, Yingying; Lin, Weixuan; He, Huiming; Xie, Guoyun; Liang, Han; An, Na; Wang, Hui; Teixeira, Manuel; Vieira, Joana; Liang, Wenhua; Zhao, Xin; Peng, Zhiyu; Mu, Feng; Zhang, Xiuqing; Xu, Xun; Yang, Huanming; Kristiansen, Karsten; Zhong, Nanshan; Wang, Jun; Pan-Hammarström, Qiang; He, Jianxing; Wang, Jian.

In: Nature Communications, Vol. 6, 10131, 2015.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wu, K, Zhang, X, Li, F, Xiao, D, Hou, Y, Zhu, S, Liu, D, Ye, X, Ye, M, Yang, J, Shao, L, Pan, H, Lu, N, Yu, Y, Liu, L, Li, J, Huang, L, Tang, H, Deng, Q, Zheng, Y, Peng, L, Liu, G, Gu, X, He, P, Gu, Y, Lin, W, He, H, Xie, G, Liang, H, An, N, Wang, H, Teixeira, M, Vieira, J, Liang, W, Zhao, X, Peng, Z, Mu, F, Zhang, X, Xu, X, Yang, H, Kristiansen, K, Zhong, N, Wang, J, Pan-Hammarström, Q, He, J & Wang, J 2015, 'Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas', Nature Communications, vol. 6, 10131. https://doi.org/10.1038/ncomms10131

APA

Wu, K., Zhang, X., Li, F., Xiao, D., Hou, Y., Zhu, S., Liu, D., Ye, X., Ye, M., Yang, J., Shao, L., Pan, H., Lu, N., Yu, Y., Liu, L., Li, J., Huang, L., Tang, H., Deng, Q., ... Wang, J. (2015). Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas. Nature Communications, 6, [10131]. https://doi.org/10.1038/ncomms10131

Vancouver

Wu K, Zhang X, Li F, Xiao D, Hou Y, Zhu S et al. Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas. Nature Communications. 2015;6. 10131. https://doi.org/10.1038/ncomms10131

Author

Wu, Kui ; Zhang, Xin ; Li, Fuqiang ; Xiao, Dakai ; Hou, Yong ; Zhu, Shida ; Liu, Dongbing ; Ye, Xiaofei ; Ye, Mingzhi ; Yang, Jie ; Shao, Libin ; Pan, Hui ; Lu, Na ; Yu, Yuan ; Liu, Liping ; Li, Jin ; Huang, Liyan ; Tang, Hailing ; Deng, Qiuhua ; Zheng, Yue ; Peng, Lihua ; Liu, Geng ; Gu, Xia ; He, Ping ; Gu, Yingying ; Lin, Weixuan ; He, Huiming ; Xie, Guoyun ; Liang, Han ; An, Na ; Wang, Hui ; Teixeira, Manuel ; Vieira, Joana ; Liang, Wenhua ; Zhao, Xin ; Peng, Zhiyu ; Mu, Feng ; Zhang, Xiuqing ; Xu, Xun ; Yang, Huanming ; Kristiansen, Karsten ; Zhong, Nanshan ; Wang, Jun ; Pan-Hammarström, Qiang ; He, Jianxing ; Wang, Jian. / Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas. In: Nature Communications. 2015 ; Vol. 6.

Bibtex

@article{f129bf6c853048bf803fde7b8e0e6888,
title = "Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas",
abstract = "The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study represents the first large-scale sequencing effort on lung adenocarcinoma in Asian patients and provides a comprehensive mutational landscape for both primary and metastatic tumours. This may thus form a basis for personalized medical care and shed light on the molecular pathogenesis of metastatic lung adenocarcinoma.",
author = "Kui Wu and Xin Zhang and Fuqiang Li and Dakai Xiao and Yong Hou and Shida Zhu and Dongbing Liu and Xiaofei Ye and Mingzhi Ye and Jie Yang and Libin Shao and Hui Pan and Na Lu and Yuan Yu and Liping Liu and Jin Li and Liyan Huang and Hailing Tang and Qiuhua Deng and Yue Zheng and Lihua Peng and Geng Liu and Xia Gu and Ping He and Yingying Gu and Weixuan Lin and Huiming He and Guoyun Xie and Han Liang and Na An and Hui Wang and Manuel Teixeira and Joana Vieira and Wenhua Liang and Xin Zhao and Zhiyu Peng and Feng Mu and Xiuqing Zhang and Xun Xu and Huanming Yang and Karsten Kristiansen and Nanshan Zhong and Jun Wang and Qiang Pan-Hammarstr{\"o}m and Jianxing He and Jian Wang",
year = "2015",
doi = "10.1038/ncomms10131",
language = "English",
volume = "6",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas

AU - Wu, Kui

AU - Zhang, Xin

AU - Li, Fuqiang

AU - Xiao, Dakai

AU - Hou, Yong

AU - Zhu, Shida

AU - Liu, Dongbing

AU - Ye, Xiaofei

AU - Ye, Mingzhi

AU - Yang, Jie

AU - Shao, Libin

AU - Pan, Hui

AU - Lu, Na

AU - Yu, Yuan

AU - Liu, Liping

AU - Li, Jin

AU - Huang, Liyan

AU - Tang, Hailing

AU - Deng, Qiuhua

AU - Zheng, Yue

AU - Peng, Lihua

AU - Liu, Geng

AU - Gu, Xia

AU - He, Ping

AU - Gu, Yingying

AU - Lin, Weixuan

AU - He, Huiming

AU - Xie, Guoyun

AU - Liang, Han

AU - An, Na

AU - Wang, Hui

AU - Teixeira, Manuel

AU - Vieira, Joana

AU - Liang, Wenhua

AU - Zhao, Xin

AU - Peng, Zhiyu

AU - Mu, Feng

AU - Zhang, Xiuqing

AU - Xu, Xun

AU - Yang, Huanming

AU - Kristiansen, Karsten

AU - Zhong, Nanshan

AU - Wang, Jun

AU - Pan-Hammarström, Qiang

AU - He, Jianxing

AU - Wang, Jian

PY - 2015

Y1 - 2015

N2 - The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study represents the first large-scale sequencing effort on lung adenocarcinoma in Asian patients and provides a comprehensive mutational landscape for both primary and metastatic tumours. This may thus form a basis for personalized medical care and shed light on the molecular pathogenesis of metastatic lung adenocarcinoma.

AB - The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study represents the first large-scale sequencing effort on lung adenocarcinoma in Asian patients and provides a comprehensive mutational landscape for both primary and metastatic tumours. This may thus form a basis for personalized medical care and shed light on the molecular pathogenesis of metastatic lung adenocarcinoma.

U2 - 10.1038/ncomms10131

DO - 10.1038/ncomms10131

M3 - Journal article

C2 - 26647728

AN - SCOPUS:84949570896

VL - 6

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 10131

ER -

ID: 153601752