Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression

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Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression. / Popławski, Andrzej B; Jankowski, Michał; Erickson, Stephen W; Díaz de Ståhl, Teresita; Partridge, E Christopher; Crasto, Chiquito; Guo, Jingyu; Gibson, John; Menzel, Uwe; Bruder, Carl Eg; Kaczmarczyk, Aneta; Benetkiewicz, Magdalena; Andersson, Robin; Sandgren, Johanna; Zegarska, Barbara; Bała, Dariusz; Srutek, Ewa; Allison, David B; Piotrowski, Arkadiusz; Zegarski, Wojciech; Dumanski, Jan P.

In: European Journal of Human Genetics, Vol. 18, No. 5, 05.2010, p. 560-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Popławski, AB, Jankowski, M, Erickson, SW, Díaz de Ståhl, T, Partridge, EC, Crasto, C, Guo, J, Gibson, J, Menzel, U, Bruder, CE, Kaczmarczyk, A, Benetkiewicz, M, Andersson, R, Sandgren, J, Zegarska, B, Bała, D, Srutek, E, Allison, DB, Piotrowski, A, Zegarski, W & Dumanski, JP 2010, 'Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression', European Journal of Human Genetics, vol. 18, no. 5, pp. 560-8. https://doi.org/10.1038/ejhg.2009.230

APA

Popławski, A. B., Jankowski, M., Erickson, S. W., Díaz de Ståhl, T., Partridge, E. C., Crasto, C., Guo, J., Gibson, J., Menzel, U., Bruder, C. E., Kaczmarczyk, A., Benetkiewicz, M., Andersson, R., Sandgren, J., Zegarska, B., Bała, D., Srutek, E., Allison, D. B., Piotrowski, A., ... Dumanski, J. P. (2010). Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression. European Journal of Human Genetics, 18(5), 560-8. https://doi.org/10.1038/ejhg.2009.230

Vancouver

Popławski AB, Jankowski M, Erickson SW, Díaz de Ståhl T, Partridge EC, Crasto C et al. Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression. European Journal of Human Genetics. 2010 May;18(5):560-8. https://doi.org/10.1038/ejhg.2009.230

Author

Popławski, Andrzej B ; Jankowski, Michał ; Erickson, Stephen W ; Díaz de Ståhl, Teresita ; Partridge, E Christopher ; Crasto, Chiquito ; Guo, Jingyu ; Gibson, John ; Menzel, Uwe ; Bruder, Carl Eg ; Kaczmarczyk, Aneta ; Benetkiewicz, Magdalena ; Andersson, Robin ; Sandgren, Johanna ; Zegarska, Barbara ; Bała, Dariusz ; Srutek, Ewa ; Allison, David B ; Piotrowski, Arkadiusz ; Zegarski, Wojciech ; Dumanski, Jan P. / Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression. In: European Journal of Human Genetics. 2010 ; Vol. 18, No. 5. pp. 560-8.

Bibtex

@article{820cdc7b30854bdeb1f41bd11aa71844,
title = "Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression",
abstract = "Breast cancer is a major cause of morbidity and mortality in women and its metastatic spread is the principal reason behind the fatal outcome. Metastasis-related research of breast cancer is however underdeveloped when compared with the abundant literature on primary tumors. We applied an unexplored approach comparing at high resolution the genomic profiles of primary tumors and synchronous axillary lymph node metastases from 13 patients with breast cancer. Overall, primary tumors displayed 20% higher number of aberrations than metastases. In all but two patients, we detected in total 157 statistically significant differences between primary lesions and matched metastases. We further observed differences that can be linked to metastatic disease and there was also an overlapping pattern of changes between different patients. Many of the differences described here have been previously linked to poor patient survival, suggesting that this is a viable approach toward finding biomarkers for disease progression and definition of new targets useful for development of anticancer drugs. Frequent genetic differences between primary tumors and metastases in breast cancer also question, at least to some extent, the role of primary tumors as a surrogate subject of study for the systemic disease.",
keywords = "Adult, Aged, Breast Neoplasms, Chromosomes, Human, Pair 11, DNA Copy Number Variations, Disease Progression, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genome, Human, Humans, Lymphatic Metastasis, Middle Aged, Oligonucleotide Array Sequence Analysis, Tumor Markers, Biological",
author = "Pop{\l}awski, {Andrzej B} and Micha{\l} Jankowski and Erickson, {Stephen W} and {D{\'i}az de St{\aa}hl}, Teresita and Partridge, {E Christopher} and Chiquito Crasto and Jingyu Guo and John Gibson and Uwe Menzel and Bruder, {Carl Eg} and Aneta Kaczmarczyk and Magdalena Benetkiewicz and Robin Andersson and Johanna Sandgren and Barbara Zegarska and Dariusz Ba{\l}a and Ewa Srutek and Allison, {David B} and Arkadiusz Piotrowski and Wojciech Zegarski and Dumanski, {Jan P}",
year = "2010",
month = may,
doi = "10.1038/ejhg.2009.230",
language = "English",
volume = "18",
pages = "560--8",
journal = "European Journal of Human Genetics",
issn = "1018-4813",
publisher = "nature publishing group",
number = "5",

}

RIS

TY - JOUR

T1 - Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression

AU - Popławski, Andrzej B

AU - Jankowski, Michał

AU - Erickson, Stephen W

AU - Díaz de Ståhl, Teresita

AU - Partridge, E Christopher

AU - Crasto, Chiquito

AU - Guo, Jingyu

AU - Gibson, John

AU - Menzel, Uwe

AU - Bruder, Carl Eg

AU - Kaczmarczyk, Aneta

AU - Benetkiewicz, Magdalena

AU - Andersson, Robin

AU - Sandgren, Johanna

AU - Zegarska, Barbara

AU - Bała, Dariusz

AU - Srutek, Ewa

AU - Allison, David B

AU - Piotrowski, Arkadiusz

AU - Zegarski, Wojciech

AU - Dumanski, Jan P

PY - 2010/5

Y1 - 2010/5

N2 - Breast cancer is a major cause of morbidity and mortality in women and its metastatic spread is the principal reason behind the fatal outcome. Metastasis-related research of breast cancer is however underdeveloped when compared with the abundant literature on primary tumors. We applied an unexplored approach comparing at high resolution the genomic profiles of primary tumors and synchronous axillary lymph node metastases from 13 patients with breast cancer. Overall, primary tumors displayed 20% higher number of aberrations than metastases. In all but two patients, we detected in total 157 statistically significant differences between primary lesions and matched metastases. We further observed differences that can be linked to metastatic disease and there was also an overlapping pattern of changes between different patients. Many of the differences described here have been previously linked to poor patient survival, suggesting that this is a viable approach toward finding biomarkers for disease progression and definition of new targets useful for development of anticancer drugs. Frequent genetic differences between primary tumors and metastases in breast cancer also question, at least to some extent, the role of primary tumors as a surrogate subject of study for the systemic disease.

AB - Breast cancer is a major cause of morbidity and mortality in women and its metastatic spread is the principal reason behind the fatal outcome. Metastasis-related research of breast cancer is however underdeveloped when compared with the abundant literature on primary tumors. We applied an unexplored approach comparing at high resolution the genomic profiles of primary tumors and synchronous axillary lymph node metastases from 13 patients with breast cancer. Overall, primary tumors displayed 20% higher number of aberrations than metastases. In all but two patients, we detected in total 157 statistically significant differences between primary lesions and matched metastases. We further observed differences that can be linked to metastatic disease and there was also an overlapping pattern of changes between different patients. Many of the differences described here have been previously linked to poor patient survival, suggesting that this is a viable approach toward finding biomarkers for disease progression and definition of new targets useful for development of anticancer drugs. Frequent genetic differences between primary tumors and metastases in breast cancer also question, at least to some extent, the role of primary tumors as a surrogate subject of study for the systemic disease.

KW - Adult

KW - Aged

KW - Breast Neoplasms

KW - Chromosomes, Human, Pair 11

KW - DNA Copy Number Variations

KW - Disease Progression

KW - Female

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Genome, Human

KW - Humans

KW - Lymphatic Metastasis

KW - Middle Aged

KW - Oligonucleotide Array Sequence Analysis

KW - Tumor Markers, Biological

U2 - 10.1038/ejhg.2009.230

DO - 10.1038/ejhg.2009.230

M3 - Journal article

C2 - 20051991

VL - 18

SP - 560

EP - 568

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

SN - 1018-4813

IS - 5

ER -

ID: 106775576