Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. / Gui, Yaoting; Guo, Guangwu; Huang, Yi; Hu, Xueda; Tang, Aifa; Gao, Shengjie; Wu, Renhua; Chen, Chao; Li, Xianxin; Zhou, Liang; He, Minghui; Li, Zesong; Sun, Xiaojuan; Jia, Wenlong; Chen, Jinnong; Yang, Shangming; Zhou, Fangjian; Zhao, Xiaokun; Wan, Shengqing; Ye, Rui; Liang, Chaozhao; Liu, chunxiao ; Huang, Peide; Liu, Chunxiao; Jiang, Hui; Wang, Yong; Zheng, Hancheng; Sun, Liang; Liu, Xingwang; Jiang, Zhimao; Feng, Dafei; Chen, Xi Jing; Wu, Song; Zou, Jing; Zhang, Zhongfu; Yang, Ruilin; Zhao, Jun; Xu, Congjie; Yin, Weihua; Guan, Zhichen; Ye, Jiongxian; Zhang, Hong; Li, Jingxiang; Kristiansen, Karsten; Nickerson, Michael L; Theodorescu, Dan; Li, Yingrui; Zhang, Xiuqing; Li, Songgang; Wang, Jian; Yang, Huanming; Wang, Jun; Cai, Zhiming.
In: Nature Genetics, Vol. 43, No. 9, 2011, p. 875-8.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
AU - Gui, Yaoting
AU - Guo, Guangwu
AU - Huang, Yi
AU - Hu, Xueda
AU - Tang, Aifa
AU - Gao, Shengjie
AU - Wu, Renhua
AU - Chen, Chao
AU - Li, Xianxin
AU - Zhou, Liang
AU - He, Minghui
AU - Li, Zesong
AU - Sun, Xiaojuan
AU - Jia, Wenlong
AU - Chen, Jinnong
AU - Yang, Shangming
AU - Zhou, Fangjian
AU - Zhao, Xiaokun
AU - Wan, Shengqing
AU - Ye, Rui
AU - Liang, Chaozhao
AU - Liu, chunxiao
AU - Huang, Peide
AU - Liu, Chunxiao
AU - Jiang, Hui
AU - Wang, Yong
AU - Zheng, Hancheng
AU - Sun, Liang
AU - Liu, Xingwang
AU - Jiang, Zhimao
AU - Feng, Dafei
AU - Chen, Xi Jing
AU - Wu, Song
AU - Zou, Jing
AU - Zhang, Zhongfu
AU - Yang, Ruilin
AU - Zhao, Jun
AU - Xu, Congjie
AU - Yin, Weihua
AU - Guan, Zhichen
AU - Ye, Jiongxian
AU - Zhang, Hong
AU - Li, Jingxiang
AU - Kristiansen, Karsten
AU - Nickerson, Michael L
AU - Theodorescu, Dan
AU - Li, Yingrui
AU - Zhang, Xiuqing
AU - Li, Songgang
AU - Wang, Jian
AU - Yang, Huanming
AU - Wang, Jun
AU - Cai, Zhiming
PY - 2011
Y1 - 2011
N2 - Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
AB - Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
KW - Carcinoma, Transitional Cell
KW - Chromatin Assembly and Disassembly
KW - Chromosome Aberrations
KW - Gene Expression Regulation, Neoplastic
KW - Humans
KW - Mutation
KW - Urinary Bladder Neoplasms
U2 - 10.1038/ng.907
DO - 10.1038/ng.907
M3 - Letter
C2 - 21822268
VL - 43
SP - 875
EP - 878
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 9
ER -
ID: 35397664