Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration. / Shao, Yong; Wang, Xiao-Bo; Zhang, Jin-Jin; Li, Ming Li; Wu, Shou-Song; Ma, Xi-Yao; Wang, Xue; Zhao, Hui-Fang; Li, Yuan; Zhu, Helen He; Irwin, David M.; Wang, De-Peng; Zhang, Guo-Jie; Ruan, Jue; Wu, Dong-Dong.

In: Nature Communications, Vol. 11, 2656, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Shao, Y, Wang, X-B, Zhang, J-J, Li, ML, Wu, S-S, Ma, X-Y, Wang, X, Zhao, H-F, Li, Y, Zhu, HH, Irwin, DM, Wang, D-P, Zhang, G-J, Ruan, J & Wu, D-D 2020, 'Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration', Nature Communications, vol. 11, 2656. https://doi.org/10.1038/s41467-020-16454-8

APA

Shao, Y., Wang, X-B., Zhang, J-J., Li, M. L., Wu, S-S., Ma, X-Y., Wang, X., Zhao, H-F., Li, Y., Zhu, H. H., Irwin, D. M., Wang, D-P., Zhang, G-J., Ruan, J., & Wu, D-D. (2020). Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration. Nature Communications, 11, [2656]. https://doi.org/10.1038/s41467-020-16454-8

Vancouver

Shao Y, Wang X-B, Zhang J-J, Li ML, Wu S-S, Ma X-Y et al. Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration. Nature Communications. 2020;11. 2656. https://doi.org/10.1038/s41467-020-16454-8

Author

Shao, Yong ; Wang, Xiao-Bo ; Zhang, Jin-Jin ; Li, Ming Li ; Wu, Shou-Song ; Ma, Xi-Yao ; Wang, Xue ; Zhao, Hui-Fang ; Li, Yuan ; Zhu, Helen He ; Irwin, David M. ; Wang, De-Peng ; Zhang, Guo-Jie ; Ruan, Jue ; Wu, Dong-Dong. / Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration. In: Nature Communications. 2020 ; Vol. 11.

Bibtex

@article{bff524fedf1446ada818c6c7ae8b86a1,
title = "Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration",
abstract = "The earthworm is particularly fascinating to biologists because of its strong regenerative capacity. However, many aspects of its regeneration in nature remain elusive. Here we report chromosome-level genome, large-scale transcriptome and single-cell RNA-sequencing data during earthworm (Eisenia andrei) regeneration. We observe expansion of LINE2 transposable elements and gene families functionally related to regeneration (for example, EGFR, epidermal growth factor receptor) particularly for genes exhibiting differential expression during earthworm regeneration. Temporal gene expression trajectories identify transcriptional regulatory factors that are potentially crucial for initiating cell proliferation and differentiation during regeneration. Furthermore, early growth response genes related to regeneration are transcriptionally activated in both the earthworm and planarian. Meanwhile, single-cell RNA-sequencing provides insight into the regenerative process at a cellular level and finds that the largest proportion of cells present during regeneration are stem cells.",
author = "Yong Shao and Xiao-Bo Wang and Jin-Jin Zhang and Li, {Ming Li} and Shou-Song Wu and Xi-Yao Ma and Xue Wang and Hui-Fang Zhao and Yuan Li and Zhu, {Helen He} and Irwin, {David M.} and De-Peng Wang and Guo-Jie Zhang and Jue Ruan and Dong-Dong Wu",
year = "2020",
doi = "10.1038/s41467-020-16454-8",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration

AU - Shao, Yong

AU - Wang, Xiao-Bo

AU - Zhang, Jin-Jin

AU - Li, Ming Li

AU - Wu, Shou-Song

AU - Ma, Xi-Yao

AU - Wang, Xue

AU - Zhao, Hui-Fang

AU - Li, Yuan

AU - Zhu, Helen He

AU - Irwin, David M.

AU - Wang, De-Peng

AU - Zhang, Guo-Jie

AU - Ruan, Jue

AU - Wu, Dong-Dong

PY - 2020

Y1 - 2020

N2 - The earthworm is particularly fascinating to biologists because of its strong regenerative capacity. However, many aspects of its regeneration in nature remain elusive. Here we report chromosome-level genome, large-scale transcriptome and single-cell RNA-sequencing data during earthworm (Eisenia andrei) regeneration. We observe expansion of LINE2 transposable elements and gene families functionally related to regeneration (for example, EGFR, epidermal growth factor receptor) particularly for genes exhibiting differential expression during earthworm regeneration. Temporal gene expression trajectories identify transcriptional regulatory factors that are potentially crucial for initiating cell proliferation and differentiation during regeneration. Furthermore, early growth response genes related to regeneration are transcriptionally activated in both the earthworm and planarian. Meanwhile, single-cell RNA-sequencing provides insight into the regenerative process at a cellular level and finds that the largest proportion of cells present during regeneration are stem cells.

AB - The earthworm is particularly fascinating to biologists because of its strong regenerative capacity. However, many aspects of its regeneration in nature remain elusive. Here we report chromosome-level genome, large-scale transcriptome and single-cell RNA-sequencing data during earthworm (Eisenia andrei) regeneration. We observe expansion of LINE2 transposable elements and gene families functionally related to regeneration (for example, EGFR, epidermal growth factor receptor) particularly for genes exhibiting differential expression during earthworm regeneration. Temporal gene expression trajectories identify transcriptional regulatory factors that are potentially crucial for initiating cell proliferation and differentiation during regeneration. Furthermore, early growth response genes related to regeneration are transcriptionally activated in both the earthworm and planarian. Meanwhile, single-cell RNA-sequencing provides insight into the regenerative process at a cellular level and finds that the largest proportion of cells present during regeneration are stem cells.

U2 - 10.1038/s41467-020-16454-8

DO - 10.1038/s41467-020-16454-8

M3 - Journal article

C2 - 32461609

AN - SCOPUS:85085588630

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2656

ER -

ID: 243193994