Genome sequence and genomic analysis of liver abscess caused by hypervirulent Klebsiella pneumoniae

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genome sequence and genomic analysis of liver abscess caused by hypervirulent Klebsiella pneumoniae. / Pei, Na; Liu, Xin; Jian, Zijuan; Yan, Qun; Liu, Qingxia; Kristiansen, Karsten; Li, Junhua; Liu, Wenen.

In: 3 Biotech, Vol. 13, No. 3, 76, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pei, N, Liu, X, Jian, Z, Yan, Q, Liu, Q, Kristiansen, K, Li, J & Liu, W 2023, 'Genome sequence and genomic analysis of liver abscess caused by hypervirulent Klebsiella pneumoniae', 3 Biotech, vol. 13, no. 3, 76. https://doi.org/10.1007/s13205-023-03458-6

APA

Pei, N., Liu, X., Jian, Z., Yan, Q., Liu, Q., Kristiansen, K., Li, J., & Liu, W. (2023). Genome sequence and genomic analysis of liver abscess caused by hypervirulent Klebsiella pneumoniae. 3 Biotech, 13(3), [76]. https://doi.org/10.1007/s13205-023-03458-6

Vancouver

Pei N, Liu X, Jian Z, Yan Q, Liu Q, Kristiansen K et al. Genome sequence and genomic analysis of liver abscess caused by hypervirulent Klebsiella pneumoniae. 3 Biotech. 2023;13(3). 76. https://doi.org/10.1007/s13205-023-03458-6

Author

Pei, Na ; Liu, Xin ; Jian, Zijuan ; Yan, Qun ; Liu, Qingxia ; Kristiansen, Karsten ; Li, Junhua ; Liu, Wenen. / Genome sequence and genomic analysis of liver abscess caused by hypervirulent Klebsiella pneumoniae. In: 3 Biotech. 2023 ; Vol. 13, No. 3.

Bibtex

@article{0e03ca9e469a40daa6609e1e344b3bce,
title = "Genome sequence and genomic analysis of liver abscess caused by hypervirulent Klebsiella pneumoniae",
abstract = "Hypervirulent Klebsiella pneumoniae (hvKp) is an important pathotype with enhanced virulence features compared with classical K. pneumoniae (cKp). hvKp usually causes life-threatening infections in the community, often affecting young and healthy individuals. During the past few decades, hvKp-induced liver abscess has been increasingly reported in Asia and is emerging as a global disease. To better comprehend the molecular characteristics of hvKp-induced liver abscess and recognize the global dissemination of hypervirulent strains with resistance determinants, we sequenced the whole genome of 26 K. pneumoniae strains from patients with liver abscess (KLA) and investigated the clinical factors related to different phenotype groups. The epidemiology, virulence-related factors, and antimicrobial resistance determinants were also discussed. The age, gender, and whether being hospitalized showed no differences among the string-positive and -negative groups were also studied. The assembly and annotation suggested that most of the 26 new liver abscess-causing hvKp strains were ST23-K1 or ST86-K2, and only one of the strains exhibited multidrug resistance. Compared with the existing 36 global liver abscess genome sequences, higher sequence type and virulence gene diversity were found in the new genomes. The clinical characteristics and genomic data of the isolated strains will enrich our knowledge for comparative genomic studies, allowing the better understanding of hvKp characteristics and evolution.",
keywords = "Comparative genomics, Genome sequencing, Hypervirulent, Klebsiella pneumoniae, Liver abscess",
author = "Na Pei and Xin Liu and Zijuan Jian and Qun Yan and Qingxia Liu and Karsten Kristiansen and Junhua Li and Wenen Liu",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1007/s13205-023-03458-6",
language = "English",
volume = "13",
journal = "3 Biotech",
issn = "2190-572X",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Genome sequence and genomic analysis of liver abscess caused by hypervirulent Klebsiella pneumoniae

AU - Pei, Na

AU - Liu, Xin

AU - Jian, Zijuan

AU - Yan, Qun

AU - Liu, Qingxia

AU - Kristiansen, Karsten

AU - Li, Junhua

AU - Liu, Wenen

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Hypervirulent Klebsiella pneumoniae (hvKp) is an important pathotype with enhanced virulence features compared with classical K. pneumoniae (cKp). hvKp usually causes life-threatening infections in the community, often affecting young and healthy individuals. During the past few decades, hvKp-induced liver abscess has been increasingly reported in Asia and is emerging as a global disease. To better comprehend the molecular characteristics of hvKp-induced liver abscess and recognize the global dissemination of hypervirulent strains with resistance determinants, we sequenced the whole genome of 26 K. pneumoniae strains from patients with liver abscess (KLA) and investigated the clinical factors related to different phenotype groups. The epidemiology, virulence-related factors, and antimicrobial resistance determinants were also discussed. The age, gender, and whether being hospitalized showed no differences among the string-positive and -negative groups were also studied. The assembly and annotation suggested that most of the 26 new liver abscess-causing hvKp strains were ST23-K1 or ST86-K2, and only one of the strains exhibited multidrug resistance. Compared with the existing 36 global liver abscess genome sequences, higher sequence type and virulence gene diversity were found in the new genomes. The clinical characteristics and genomic data of the isolated strains will enrich our knowledge for comparative genomic studies, allowing the better understanding of hvKp characteristics and evolution.

AB - Hypervirulent Klebsiella pneumoniae (hvKp) is an important pathotype with enhanced virulence features compared with classical K. pneumoniae (cKp). hvKp usually causes life-threatening infections in the community, often affecting young and healthy individuals. During the past few decades, hvKp-induced liver abscess has been increasingly reported in Asia and is emerging as a global disease. To better comprehend the molecular characteristics of hvKp-induced liver abscess and recognize the global dissemination of hypervirulent strains with resistance determinants, we sequenced the whole genome of 26 K. pneumoniae strains from patients with liver abscess (KLA) and investigated the clinical factors related to different phenotype groups. The epidemiology, virulence-related factors, and antimicrobial resistance determinants were also discussed. The age, gender, and whether being hospitalized showed no differences among the string-positive and -negative groups were also studied. The assembly and annotation suggested that most of the 26 new liver abscess-causing hvKp strains were ST23-K1 or ST86-K2, and only one of the strains exhibited multidrug resistance. Compared with the existing 36 global liver abscess genome sequences, higher sequence type and virulence gene diversity were found in the new genomes. The clinical characteristics and genomic data of the isolated strains will enrich our knowledge for comparative genomic studies, allowing the better understanding of hvKp characteristics and evolution.

KW - Comparative genomics

KW - Genome sequencing

KW - Hypervirulent

KW - Klebsiella pneumoniae

KW - Liver abscess

U2 - 10.1007/s13205-023-03458-6

DO - 10.1007/s13205-023-03458-6

M3 - Journal article

C2 - 36748017

AN - SCOPUS:85147439886

VL - 13

JO - 3 Biotech

JF - 3 Biotech

SN - 2190-572X

IS - 3

M1 - 76

ER -

ID: 335963586