Genomic and chromatin signals underlying transcription start-site selection
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Genomic and chromatin signals underlying transcription start-site selection. / Valen, Eivind; Sandelin, Albin Gustav.
In: Trends in Genetics, Vol. 27, No. 11, 2011, p. 475-485.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genomic and chromatin signals underlying transcription start-site selection
AU - Valen, Eivind
AU - Sandelin, Albin Gustav
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - A central question in cellular biology is how the cell regulates transcription and discerns when and where to initiate it. Locating transcription start sites (TSSs), the signals that specify them, and ultimately elucidating the mechanisms of regulated initiation has therefore been a recurrent theme. In recent years substantial progress has been made towards this goal, spurred by the possibility of applying genome-wide, sequencing-based analysis. We now have a large collection of high-resolution datasets identifying locations of TSSs, protein-DNA interactions, and chromatin features over whole genomes; the field is now faced with the daunting challenge of translating these descriptive maps into quantitative and predictive models describing the underlying biology. We review here the genomic and chromatin features that underlie TSS selection and usage, focusing on the differences between the major classes of core promoters.
AB - A central question in cellular biology is how the cell regulates transcription and discerns when and where to initiate it. Locating transcription start sites (TSSs), the signals that specify them, and ultimately elucidating the mechanisms of regulated initiation has therefore been a recurrent theme. In recent years substantial progress has been made towards this goal, spurred by the possibility of applying genome-wide, sequencing-based analysis. We now have a large collection of high-resolution datasets identifying locations of TSSs, protein-DNA interactions, and chromatin features over whole genomes; the field is now faced with the daunting challenge of translating these descriptive maps into quantitative and predictive models describing the underlying biology. We review here the genomic and chromatin features that underlie TSS selection and usage, focusing on the differences between the major classes of core promoters.
U2 - 10.1016/j.tig.2011.08.001
DO - 10.1016/j.tig.2011.08.001
M3 - Journal article
C2 - 21924514
VL - 27
SP - 475
EP - 485
JO - Trends in Genetics
JF - Trends in Genetics
SN - 0168-9525
IS - 11
ER -
ID: 34408756