Gut microbiome development along the colorectal adenoma-carcinoma sequence

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Gut microbiome development along the colorectal adenoma-carcinoma sequence. / Feng, Qiang; Liang, Suisha; Jia, Huijue; Stadlmayr, Andreas; Tang, Longqing; Lan, Zhou; Zhang, Dongya; Xia, Huihua; Xu, Xiaoying; Jie, Zhuye; Su, Lili; Li, Xiaoping; Li, Xin; Li, Junhua; Xiao, Liang; Huber-Schönauer, Ursula; Niederseer, David; Xu, Xun; Al-Aama, Jumana Yousuf; Yang, Huanming; Wang, Jian; Kristiansen, Karsten; Arumugam, Manimozhiyan; Tilg, Herbert; Datz, Christian; Wang, Jun.

In: Nature Communications, Vol. 6, 6528, 2015.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Feng, Q, Liang, S, Jia, H, Stadlmayr, A, Tang, L, Lan, Z, Zhang, D, Xia, H, Xu, X, Jie, Z, Su, L, Li, X, Li, X, Li, J, Xiao, L, Huber-Schönauer, U, Niederseer, D, Xu, X, Al-Aama, JY, Yang, H, Wang, J, Kristiansen, K, Arumugam, M, Tilg, H, Datz, C & Wang, J 2015, 'Gut microbiome development along the colorectal adenoma-carcinoma sequence', Nature Communications, vol. 6, 6528. https://doi.org/10.1038/ncomms7528

APA

Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., Su, L., Li, X., Li, X., Li, J., Xiao, L., Huber-Schönauer, U., Niederseer, D., Xu, X., Al-Aama, J. Y., ... Wang, J. (2015). Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nature Communications, 6, [6528]. https://doi.org/10.1038/ncomms7528

Vancouver

Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z et al. Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nature Communications. 2015;6. 6528. https://doi.org/10.1038/ncomms7528

Author

Feng, Qiang ; Liang, Suisha ; Jia, Huijue ; Stadlmayr, Andreas ; Tang, Longqing ; Lan, Zhou ; Zhang, Dongya ; Xia, Huihua ; Xu, Xiaoying ; Jie, Zhuye ; Su, Lili ; Li, Xiaoping ; Li, Xin ; Li, Junhua ; Xiao, Liang ; Huber-Schönauer, Ursula ; Niederseer, David ; Xu, Xun ; Al-Aama, Jumana Yousuf ; Yang, Huanming ; Wang, Jian ; Kristiansen, Karsten ; Arumugam, Manimozhiyan ; Tilg, Herbert ; Datz, Christian ; Wang, Jun. / Gut microbiome development along the colorectal adenoma-carcinoma sequence. In: Nature Communications. 2015 ; Vol. 6.

Bibtex

@article{031319ca83404c0d897ea4ba8b1d96b4,
title = "Gut microbiome development along the colorectal adenoma-carcinoma sequence",
abstract = "Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.",
author = "Qiang Feng and Suisha Liang and Huijue Jia and Andreas Stadlmayr and Longqing Tang and Zhou Lan and Dongya Zhang and Huihua Xia and Xiaoying Xu and Zhuye Jie and Lili Su and Xiaoping Li and Xin Li and Junhua Li and Liang Xiao and Ursula Huber-Sch{\"o}nauer and David Niederseer and Xun Xu and Al-Aama, {Jumana Yousuf} and Huanming Yang and Jian Wang and Karsten Kristiansen and Manimozhiyan Arumugam and Herbert Tilg and Christian Datz and Jun Wang",
year = "2015",
doi = "10.1038/ncomms7528",
language = "English",
volume = "6",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Gut microbiome development along the colorectal adenoma-carcinoma sequence

AU - Feng, Qiang

AU - Liang, Suisha

AU - Jia, Huijue

AU - Stadlmayr, Andreas

AU - Tang, Longqing

AU - Lan, Zhou

AU - Zhang, Dongya

AU - Xia, Huihua

AU - Xu, Xiaoying

AU - Jie, Zhuye

AU - Su, Lili

AU - Li, Xiaoping

AU - Li, Xin

AU - Li, Junhua

AU - Xiao, Liang

AU - Huber-Schönauer, Ursula

AU - Niederseer, David

AU - Xu, Xun

AU - Al-Aama, Jumana Yousuf

AU - Yang, Huanming

AU - Wang, Jian

AU - Kristiansen, Karsten

AU - Arumugam, Manimozhiyan

AU - Tilg, Herbert

AU - Datz, Christian

AU - Wang, Jun

PY - 2015

Y1 - 2015

N2 - Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.

AB - Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.

U2 - 10.1038/ncomms7528

DO - 10.1038/ncomms7528

M3 - Journal article

C2 - 25758642

VL - 6

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 6528

ER -

ID: 136691457