Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation. / Rada-Iglesias, Alvaro; Enroth, Stefan; Andersson, Robin; Wanders, Alkwin; Påhlman, Lars; Komorowski, Jan; Wadelius, Claes.

In: Epigenetics : official journal of the DNA Methylation Society, Vol. 4, No. 2, 16.02.2009, p. 107-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rada-Iglesias, A, Enroth, S, Andersson, R, Wanders, A, Påhlman, L, Komorowski, J & Wadelius, C 2009, 'Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation', Epigenetics : official journal of the DNA Methylation Society, vol. 4, no. 2, pp. 107-13.

APA

Rada-Iglesias, A., Enroth, S., Andersson, R., Wanders, A., Påhlman, L., Komorowski, J., & Wadelius, C. (2009). Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation. Epigenetics : official journal of the DNA Methylation Society, 4(2), 107-13.

Vancouver

Rada-Iglesias A, Enroth S, Andersson R, Wanders A, Påhlman L, Komorowski J et al. Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation. Epigenetics : official journal of the DNA Methylation Society. 2009 Feb 16;4(2):107-13.

Author

Rada-Iglesias, Alvaro ; Enroth, Stefan ; Andersson, Robin ; Wanders, Alkwin ; Påhlman, Lars ; Komorowski, Jan ; Wadelius, Claes. / Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation. In: Epigenetics : official journal of the DNA Methylation Society. 2009 ; Vol. 4, No. 2. pp. 107-13.

Bibtex

@article{eb2b96efba1c477ba6f74e4848fa573f,
title = "Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation",
abstract = "DNA hypermethylation of gene promoters is a common epigenetic alteration occurring in cancer cells. However, little is known about the mechanisms instructing these cancer-specific DNA hypermethylation events. Recent reports have suggested that genes bound by polycomb/Histone H3 lysine 27 trimethylation (H3K27me3) in embryonic stem (ES) cells are frequent targets for cancer-specific DNA hypermethylation. This polycomb-premarking is assumed to be restrained to ES cells, even though almost no polycomb/H3K27me3 binding profiles are available for differentiated tissues. We generated H3K27me3 profiles in human normal colon and they significantly overlapped with those of ES cells and genes hypermethylated in colorectal cancer (CRC). Moreover, colon H3K27me3 was more restricted to genes hypermethylated in CRC, while ES H3K27me3 was also common in genes hypermethylated in other tumors. Therefore, the suggested polycomb pre-marking of genes for cancer DNA hypermethylation is not necessarily limited to ES or early precursor cells but can occur later in differentiated tissues.",
keywords = "Adult, Colon, Colonic Neoplasms, DNA Methylation, Embryonic Stem Cells, Histones, Humans, Lysine, Methylation, Polycomb-Group Proteins, Repressor Proteins",
author = "Alvaro Rada-Iglesias and Stefan Enroth and Robin Andersson and Alkwin Wanders and Lars P{\aa}hlman and Jan Komorowski and Claes Wadelius",
year = "2009",
month = feb,
day = "16",
language = "English",
volume = "4",
pages = "107--13",
journal = "Epigenetics",
issn = "1559-2294",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation

AU - Rada-Iglesias, Alvaro

AU - Enroth, Stefan

AU - Andersson, Robin

AU - Wanders, Alkwin

AU - Påhlman, Lars

AU - Komorowski, Jan

AU - Wadelius, Claes

PY - 2009/2/16

Y1 - 2009/2/16

N2 - DNA hypermethylation of gene promoters is a common epigenetic alteration occurring in cancer cells. However, little is known about the mechanisms instructing these cancer-specific DNA hypermethylation events. Recent reports have suggested that genes bound by polycomb/Histone H3 lysine 27 trimethylation (H3K27me3) in embryonic stem (ES) cells are frequent targets for cancer-specific DNA hypermethylation. This polycomb-premarking is assumed to be restrained to ES cells, even though almost no polycomb/H3K27me3 binding profiles are available for differentiated tissues. We generated H3K27me3 profiles in human normal colon and they significantly overlapped with those of ES cells and genes hypermethylated in colorectal cancer (CRC). Moreover, colon H3K27me3 was more restricted to genes hypermethylated in CRC, while ES H3K27me3 was also common in genes hypermethylated in other tumors. Therefore, the suggested polycomb pre-marking of genes for cancer DNA hypermethylation is not necessarily limited to ES or early precursor cells but can occur later in differentiated tissues.

AB - DNA hypermethylation of gene promoters is a common epigenetic alteration occurring in cancer cells. However, little is known about the mechanisms instructing these cancer-specific DNA hypermethylation events. Recent reports have suggested that genes bound by polycomb/Histone H3 lysine 27 trimethylation (H3K27me3) in embryonic stem (ES) cells are frequent targets for cancer-specific DNA hypermethylation. This polycomb-premarking is assumed to be restrained to ES cells, even though almost no polycomb/H3K27me3 binding profiles are available for differentiated tissues. We generated H3K27me3 profiles in human normal colon and they significantly overlapped with those of ES cells and genes hypermethylated in colorectal cancer (CRC). Moreover, colon H3K27me3 was more restricted to genes hypermethylated in CRC, while ES H3K27me3 was also common in genes hypermethylated in other tumors. Therefore, the suggested polycomb pre-marking of genes for cancer DNA hypermethylation is not necessarily limited to ES or early precursor cells but can occur later in differentiated tissues.

KW - Adult

KW - Colon

KW - Colonic Neoplasms

KW - DNA Methylation

KW - Embryonic Stem Cells

KW - Histones

KW - Humans

KW - Lysine

KW - Methylation

KW - Polycomb-Group Proteins

KW - Repressor Proteins

M3 - Journal article

C2 - 19276669

VL - 4

SP - 107

EP - 113

JO - Epigenetics

JF - Epigenetics

SN - 1559-2294

IS - 2

ER -

ID: 106775893