How long can bacteriophage λ change its mind?

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How long can bacteriophage λ change its mind? / Semsey, Szabolcs; Campion, Christopher; Mohamed, Abdu; Svenningsen, Sine Lo.

In: Bacteriophage, Vol. 5, No. 1, 16.10.2015, p. e1012930.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Semsey, S, Campion, C, Mohamed, A & Svenningsen, SL 2015, 'How long can bacteriophage λ change its mind?', Bacteriophage, vol. 5, no. 1, pp. e1012930. https://doi.org/10.1080/21597081.2015.1012930

APA

Semsey, S., Campion, C., Mohamed, A., & Svenningsen, S. L. (2015). How long can bacteriophage λ change its mind? Bacteriophage, 5(1), e1012930. https://doi.org/10.1080/21597081.2015.1012930

Vancouver

Semsey S, Campion C, Mohamed A, Svenningsen SL. How long can bacteriophage λ change its mind? Bacteriophage. 2015 Oct 16;5(1):e1012930. https://doi.org/10.1080/21597081.2015.1012930

Author

Semsey, Szabolcs ; Campion, Christopher ; Mohamed, Abdu ; Svenningsen, Sine Lo. / How long can bacteriophage λ change its mind?. In: Bacteriophage. 2015 ; Vol. 5, No. 1. pp. e1012930.

Bibtex

@article{1b053df1af16403a87d3d27a6bea1af8,
title = "How long can bacteriophage λ change its mind?",
abstract = "A key event in the lifecycle of a temperate bacteriophage is the choice between lysis and lysogeny upon infection of a susceptible host cell. In a recent paper, we showed that a prolonged period exists after the decision to lysogenize, during which bacteriophage λ can abandon the initial decision, and instead develop lytically, as a response to the accumulation of the late lytic regulatory protein Q. Here, we present evidence that expression of Q does not induce replication of λ DNA, suggesting that the DNA to be packaged into the resulting phage progeny was already present at the time of the initial decision to lysogenize. We summarize our findings in a working model of the key determinants of the duration of the post-decision period during which it is possible for the infected cell to switch from the lysogeny decision to successful lytic development.",
author = "Szabolcs Semsey and Christopher Campion and Abdu Mohamed and Svenningsen, {Sine Lo}",
year = "2015",
month = oct,
day = "16",
doi = "10.1080/21597081.2015.1012930",
language = "English",
volume = "5",
pages = "e1012930",
journal = "Bacteriophage",
issn = "2159-7073",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - How long can bacteriophage λ change its mind?

AU - Semsey, Szabolcs

AU - Campion, Christopher

AU - Mohamed, Abdu

AU - Svenningsen, Sine Lo

PY - 2015/10/16

Y1 - 2015/10/16

N2 - A key event in the lifecycle of a temperate bacteriophage is the choice between lysis and lysogeny upon infection of a susceptible host cell. In a recent paper, we showed that a prolonged period exists after the decision to lysogenize, during which bacteriophage λ can abandon the initial decision, and instead develop lytically, as a response to the accumulation of the late lytic regulatory protein Q. Here, we present evidence that expression of Q does not induce replication of λ DNA, suggesting that the DNA to be packaged into the resulting phage progeny was already present at the time of the initial decision to lysogenize. We summarize our findings in a working model of the key determinants of the duration of the post-decision period during which it is possible for the infected cell to switch from the lysogeny decision to successful lytic development.

AB - A key event in the lifecycle of a temperate bacteriophage is the choice between lysis and lysogeny upon infection of a susceptible host cell. In a recent paper, we showed that a prolonged period exists after the decision to lysogenize, during which bacteriophage λ can abandon the initial decision, and instead develop lytically, as a response to the accumulation of the late lytic regulatory protein Q. Here, we present evidence that expression of Q does not induce replication of λ DNA, suggesting that the DNA to be packaged into the resulting phage progeny was already present at the time of the initial decision to lysogenize. We summarize our findings in a working model of the key determinants of the duration of the post-decision period during which it is possible for the infected cell to switch from the lysogeny decision to successful lytic development.

U2 - 10.1080/21597081.2015.1012930

DO - 10.1080/21597081.2015.1012930

M3 - Journal article

C2 - 26459429

VL - 5

SP - e1012930

JO - Bacteriophage

JF - Bacteriophage

SN - 2159-7073

IS - 1

ER -

ID: 163917127