Identification of let-7-regulated oncofetal genes.

Research output: Contribution to journal › Journal article › Research › peer-review

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Identification of let-7-regulated oncofetal genes. / Boyerinas, Benjamin; Park, Sun-Mi; Shomron, Noam; Hedegaard, Mads M; Vinther, Jeppe; Andersen, Jens S; Feig, Christine; Xu, Jinbo; Burge, Christopher B; Peter, Marcus E.

In: Cancer Research, Vol. 68, No. 8, 2008, p. 2587-91.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Boyerinas, B, Park, S-M, Shomron, N, Hedegaard, MM, Vinther, J, Andersen, JS, Feig, C, Xu, J, Burge, CB & Peter, ME 2008, 'Identification of let-7-regulated oncofetal genes.', Cancer Research, vol. 68, no. 8, pp. 2587-91. https://doi.org/10.1158/0008-5472.CAN-08-0264

APA

Boyerinas, B., Park, S-M., Shomron, N., Hedegaard, M. M., Vinther, J., Andersen, J. S., Feig, C., Xu, J., Burge, C. B., & Peter, M. E. (2008). Identification of let-7-regulated oncofetal genes. Cancer Research, 68(8), 2587-91. https://doi.org/10.1158/0008-5472.CAN-08-0264

Vancouver

Boyerinas B, Park S-M, Shomron N, Hedegaard MM, Vinther J, Andersen JS et al. Identification of let-7-regulated oncofetal genes. Cancer Research. 2008;68(8):2587-91. https://doi.org/10.1158/0008-5472.CAN-08-0264

Author

Boyerinas, Benjamin ; Park, Sun-Mi ; Shomron, Noam ; Hedegaard, Mads M ; Vinther, Jeppe ; Andersen, Jens S ; Feig, Christine ; Xu, Jinbo ; Burge, Christopher B ; Peter, Marcus E. / Identification of let-7-regulated oncofetal genes. In: Cancer Research. 2008 ; Vol. 68, No. 8. pp. 2587-91.

Bibtex

@article{d6d0404014f811ddbee902004c4f4f50,
title = "Identification of let-7-regulated oncofetal genes.",
abstract = "MicroRNAs (miRNA) are small RNA molecules of approximately 20 to 22 nucleotides that reduce expression of proteins through mRNA degradation and/or translational silencing. Each known miRNA has a large number of predicted targets. Members of the let-7/miR-98 family of miRNAs are up-regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, suggesting that let-7-regulated oncofetal genes (LOG) may become reexpressed in cancer cells. Using comparative bioinformatics, we have identified 12 conserved LOGs that include HMGA2 and IMP-1/CRD-BP. IMP-1 has growth-promoting activities through stabilization of c-myc mRNA. We experimentally confirmed that IMP-1 is a direct let-7 target that promotes cell growth and motility of tumor cells, and we confirmed by proteomics analysis that IMP-1 and HMGA2 are major miRNA targets. Our data suggest that a substantial part of the growth inhibitory activities of let-7 comes from suppressing the expression of IMP-1. LOGs could be novel therapeutic targets and potential biomarkers for cancer treatment. Udgivelsesdato: 2008-Apr-15",
author = "Benjamin Boyerinas and Sun-Mi Park and Noam Shomron and Hedegaard, {Mads M} and Jeppe Vinther and Andersen, {Jens S} and Christine Feig and Jinbo Xu and Burge, {Christopher B} and Peter, {Marcus E}",
note = "Key Words: cancer progression • IMP-1 • miRNA",
year = "2008",
doi = "10.1158/0008-5472.CAN-08-0264",
language = "English",
volume = "68",
pages = "2587--91",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research",
number = "8",

}

RIS

TY - JOUR

T1 - Identification of let-7-regulated oncofetal genes.

AU - Boyerinas, Benjamin

AU - Park, Sun-Mi

AU - Shomron, Noam

AU - Hedegaard, Mads M

AU - Vinther, Jeppe

AU - Andersen, Jens S

AU - Feig, Christine

AU - Xu, Jinbo

AU - Burge, Christopher B

AU - Peter, Marcus E

N1 - Key Words: cancer progression • IMP-1 • miRNA

PY - 2008

Y1 - 2008

N2 - MicroRNAs (miRNA) are small RNA molecules of approximately 20 to 22 nucleotides that reduce expression of proteins through mRNA degradation and/or translational silencing. Each known miRNA has a large number of predicted targets. Members of the let-7/miR-98 family of miRNAs are up-regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, suggesting that let-7-regulated oncofetal genes (LOG) may become reexpressed in cancer cells. Using comparative bioinformatics, we have identified 12 conserved LOGs that include HMGA2 and IMP-1/CRD-BP. IMP-1 has growth-promoting activities through stabilization of c-myc mRNA. We experimentally confirmed that IMP-1 is a direct let-7 target that promotes cell growth and motility of tumor cells, and we confirmed by proteomics analysis that IMP-1 and HMGA2 are major miRNA targets. Our data suggest that a substantial part of the growth inhibitory activities of let-7 comes from suppressing the expression of IMP-1. LOGs could be novel therapeutic targets and potential biomarkers for cancer treatment. Udgivelsesdato: 2008-Apr-15

AB - MicroRNAs (miRNA) are small RNA molecules of approximately 20 to 22 nucleotides that reduce expression of proteins through mRNA degradation and/or translational silencing. Each known miRNA has a large number of predicted targets. Members of the let-7/miR-98 family of miRNAs are up-regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, suggesting that let-7-regulated oncofetal genes (LOG) may become reexpressed in cancer cells. Using comparative bioinformatics, we have identified 12 conserved LOGs that include HMGA2 and IMP-1/CRD-BP. IMP-1 has growth-promoting activities through stabilization of c-myc mRNA. We experimentally confirmed that IMP-1 is a direct let-7 target that promotes cell growth and motility of tumor cells, and we confirmed by proteomics analysis that IMP-1 and HMGA2 are major miRNA targets. Our data suggest that a substantial part of the growth inhibitory activities of let-7 comes from suppressing the expression of IMP-1. LOGs could be novel therapeutic targets and potential biomarkers for cancer treatment. Udgivelsesdato: 2008-Apr-15

U2 - 10.1158/0008-5472.CAN-08-0264

DO - 10.1158/0008-5472.CAN-08-0264

M3 - Journal article

C2 - 18413726

VL - 68

SP - 2587

EP - 2591

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 8

ER -

ID: 3863165