Identification of odorant-receptor interactions by global mapping of the human odorome

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Identification of odorant-receptor interactions by global mapping of the human odorome. / Audouze, Karine Marie Laure; Tromelin, Anne; Le Bon, Anne Marie; Belloir, Christine; Petersen, Rasmus Koefoed; Kristiansen, Karsten; Brunak, Søren; Taboureau, Olivier.

In: PLOS ONE, Vol. 9, No. 4, 2014, p. e93037.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Audouze, KML, Tromelin, A, Le Bon, AM, Belloir, C, Petersen, RK, Kristiansen, K, Brunak, S & Taboureau, O 2014, 'Identification of odorant-receptor interactions by global mapping of the human odorome', PLOS ONE, vol. 9, no. 4, pp. e93037. https://doi.org/10.1371/journal.pone.0093037

APA

Audouze, K. M. L., Tromelin, A., Le Bon, A. M., Belloir, C., Petersen, R. K., Kristiansen, K., ... Taboureau, O. (2014). Identification of odorant-receptor interactions by global mapping of the human odorome. PLOS ONE, 9(4), e93037. https://doi.org/10.1371/journal.pone.0093037

Vancouver

Audouze KML, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K et al. Identification of odorant-receptor interactions by global mapping of the human odorome. PLOS ONE. 2014;9(4):e93037. https://doi.org/10.1371/journal.pone.0093037

Author

Audouze, Karine Marie Laure ; Tromelin, Anne ; Le Bon, Anne Marie ; Belloir, Christine ; Petersen, Rasmus Koefoed ; Kristiansen, Karsten ; Brunak, Søren ; Taboureau, Olivier. / Identification of odorant-receptor interactions by global mapping of the human odorome. In: PLOS ONE. 2014 ; Vol. 9, No. 4. pp. e93037.

Bibtex

@article{2be38e5a562c4b2f890c6018da9657a2,
title = "Identification of odorant-receptor interactions by global mapping of the human odorome",
abstract = "The human olfactory system recognizes a broad spectrum of odorants using approximately 400 different olfactory receptors (hORs). Although significant improvements of heterologous expression systems used to study interactions between ORs and odorant molecules have been made, screening the olfactory repertoire of hORs remains a tremendous challenge. We therefore developed a chemical systems level approach based on protein-protein association network to investigate novel hOR-odorant relationships. Using this new approach, we proposed and validated new bioactivities for odorant molecules and OR2W1, OR51E1 and OR5P3. As it remains largely unknown how human perception of odorants influence or prevent diseases, we also developed an odorant-protein matrix to explore global relationships between chemicals, biological targets and disease susceptibilities. We successfully experimentally demonstrated interactions between odorants and the cannabinoid receptor 1 (CB1) and the peroxisome proliferator-activated receptor gamma (PPARγ). Overall, these results illustrate the potential of integrative systems chemical biology to explore the impact of odorant molecules on human health, i.e. human odorome.",
author = "Audouze, {Karine Marie Laure} and Anne Tromelin and {Le Bon}, {Anne Marie} and Christine Belloir and Petersen, {Rasmus Koefoed} and Karsten Kristiansen and S{\o}ren Brunak and Olivier Taboureau",
year = "2014",
doi = "10.1371/journal.pone.0093037",
language = "English",
volume = "9",
pages = "e93037",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - Identification of odorant-receptor interactions by global mapping of the human odorome

AU - Audouze, Karine Marie Laure

AU - Tromelin, Anne

AU - Le Bon, Anne Marie

AU - Belloir, Christine

AU - Petersen, Rasmus Koefoed

AU - Kristiansen, Karsten

AU - Brunak, Søren

AU - Taboureau, Olivier

PY - 2014

Y1 - 2014

N2 - The human olfactory system recognizes a broad spectrum of odorants using approximately 400 different olfactory receptors (hORs). Although significant improvements of heterologous expression systems used to study interactions between ORs and odorant molecules have been made, screening the olfactory repertoire of hORs remains a tremendous challenge. We therefore developed a chemical systems level approach based on protein-protein association network to investigate novel hOR-odorant relationships. Using this new approach, we proposed and validated new bioactivities for odorant molecules and OR2W1, OR51E1 and OR5P3. As it remains largely unknown how human perception of odorants influence or prevent diseases, we also developed an odorant-protein matrix to explore global relationships between chemicals, biological targets and disease susceptibilities. We successfully experimentally demonstrated interactions between odorants and the cannabinoid receptor 1 (CB1) and the peroxisome proliferator-activated receptor gamma (PPARγ). Overall, these results illustrate the potential of integrative systems chemical biology to explore the impact of odorant molecules on human health, i.e. human odorome.

AB - The human olfactory system recognizes a broad spectrum of odorants using approximately 400 different olfactory receptors (hORs). Although significant improvements of heterologous expression systems used to study interactions between ORs and odorant molecules have been made, screening the olfactory repertoire of hORs remains a tremendous challenge. We therefore developed a chemical systems level approach based on protein-protein association network to investigate novel hOR-odorant relationships. Using this new approach, we proposed and validated new bioactivities for odorant molecules and OR2W1, OR51E1 and OR5P3. As it remains largely unknown how human perception of odorants influence or prevent diseases, we also developed an odorant-protein matrix to explore global relationships between chemicals, biological targets and disease susceptibilities. We successfully experimentally demonstrated interactions between odorants and the cannabinoid receptor 1 (CB1) and the peroxisome proliferator-activated receptor gamma (PPARγ). Overall, these results illustrate the potential of integrative systems chemical biology to explore the impact of odorant molecules on human health, i.e. human odorome.

U2 - 10.1371/journal.pone.0093037

DO - 10.1371/journal.pone.0093037

M3 - Journal article

C2 - 24695519

VL - 9

SP - e93037

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 4

ER -

ID: 110607929