Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides
Research output: Contribution to journal › Letter › Research › peer-review
Standard
Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides. / Wyche, Thomas P.; Ruzzini, Antonio C.; Beemelmanns, Christine; Kim, Ki Hyun; Klassen, Jonathan L.; Cao, Shugeng; Thomas-Poulsen, Michael; Bugni, Tim S.; Currie, Cameron R.; Clardy, Jon.
In: Organic Letters, Vol. 19, No. 7, 2017, p. 1772-1775.Research output: Contribution to journal › Letter › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides
AU - Wyche, Thomas P.
AU - Ruzzini, Antonio C.
AU - Beemelmanns, Christine
AU - Kim, Ki Hyun
AU - Klassen, Jonathan L.
AU - Cao, Shugeng
AU - Thomas-Poulsen, Michael
AU - Bugni, Tim S.
AU - Currie, Cameron R.
AU - Clardy, Jon
PY - 2017
Y1 - 2017
N2 - Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase-polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic organization of the NRPS modules within the biosynthetic gene cluster accounts for the observed structural diversity.
AB - Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase-polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic organization of the NRPS modules within the biosynthetic gene cluster accounts for the observed structural diversity.
U2 - 10.1021/acs.orglett.7b00545
DO - 10.1021/acs.orglett.7b00545
M3 - Letter
C2 - 28326787
AN - SCOPUS:85017179138
VL - 19
SP - 1772
EP - 1775
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 7
ER -
ID: 199558504