Standard
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes. / Grarup, Niels; Moltke, Ida; Andersen, Mette Korre; Dalby, Maria; Vitting-Seerup, Kristoffer; Kern, Timo Sebastian; Mahendran, Yuvaraj; Jørsboe, Emil; Larsen, Christina Viskum Lytken; Dahl-Petersen, Inger Katrine; Gilly, Arthur; Suveges, Daniel; Dedoussis, George; Zeggini, Eleftheria; Pedersen, Oluf Borbye; Andersson, Robin; Bjerregaard, Peter; Jørgensen, Marit Eika; Albrechtsen, Anders; Hansen, Torben.
In:
Nature Genetics, Vol. 50, No. 2, 2018, p. 172-174.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Grarup, N, Moltke, I, Andersen, MK, Dalby, M, Vitting-Seerup, K, Kern, TS, Mahendran, Y, Jørsboe, E, Larsen, CVL, Dahl-Petersen, IK, Gilly, A, Suveges, D, Dedoussis, G, Zeggini, E
, Pedersen, OB, Andersson, R, Bjerregaard, P, Jørgensen, ME
, Albrechtsen, A & Hansen, T 2018, '
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes',
Nature Genetics, vol. 50, no. 2, pp. 172-174.
https://doi.org/10.1038/s41588-017-0022-7
APA
Grarup, N., Moltke, I., Andersen, M. K., Dalby, M., Vitting-Seerup, K., Kern, T. S., Mahendran, Y., Jørsboe, E., Larsen, C. V. L., Dahl-Petersen, I. K., Gilly, A., Suveges, D., Dedoussis, G., Zeggini, E.
, Pedersen, O. B., Andersson, R., Bjerregaard, P., Jørgensen, M. E.
, Albrechtsen, A., & Hansen, T. (2018).
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
Nature Genetics,
50(2), 172-174.
https://doi.org/10.1038/s41588-017-0022-7
Vancouver
Grarup N, Moltke I, Andersen MK, Dalby M, Vitting-Seerup K, Kern TS et al.
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
Nature Genetics. 2018;50(2):172-174.
https://doi.org/10.1038/s41588-017-0022-7
Author
Grarup, Niels ; Moltke, Ida ; Andersen, Mette Korre ; Dalby, Maria ; Vitting-Seerup, Kristoffer ; Kern, Timo Sebastian ; Mahendran, Yuvaraj ; Jørsboe, Emil ; Larsen, Christina Viskum Lytken ; Dahl-Petersen, Inger Katrine ; Gilly, Arthur ; Suveges, Daniel ; Dedoussis, George ; Zeggini, Eleftheria ; Pedersen, Oluf Borbye ; Andersson, Robin ; Bjerregaard, Peter ; Jørgensen, Marit Eika ; Albrechtsen, Anders ; Hansen, Torben. / Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes. In: Nature Genetics. 2018 ; Vol. 50, No. 2. pp. 172-174.
Bibtex
@article{b02114f3f15842baa481074a2a859f45,
title = "Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes",
abstract = "We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. These findings provide new information on disease etiology relevant for future treatment strategies.",
author = "Niels Grarup and Ida Moltke and Andersen, {Mette Korre} and Maria Dalby and Kristoffer Vitting-Seerup and Kern, {Timo Sebastian} and Yuvaraj Mahendran and Emil J{\o}rsboe and Larsen, {Christina Viskum Lytken} and Dahl-Petersen, {Inger Katrine} and Arthur Gilly and Daniel Suveges and George Dedoussis and Eleftheria Zeggini and Pedersen, {Oluf Borbye} and Robin Andersson and Peter Bjerregaard and J{\o}rgensen, {Marit Eika} and Anders Albrechtsen and Torben Hansen",
year = "2018",
doi = "10.1038/s41588-017-0022-7",
language = "English",
volume = "50",
pages = "172--174",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "2",
}
RIS
TY - JOUR
T1 - Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
AU - Grarup, Niels
AU - Moltke, Ida
AU - Andersen, Mette Korre
AU - Dalby, Maria
AU - Vitting-Seerup, Kristoffer
AU - Kern, Timo Sebastian
AU - Mahendran, Yuvaraj
AU - Jørsboe, Emil
AU - Larsen, Christina Viskum Lytken
AU - Dahl-Petersen, Inger Katrine
AU - Gilly, Arthur
AU - Suveges, Daniel
AU - Dedoussis, George
AU - Zeggini, Eleftheria
AU - Pedersen, Oluf Borbye
AU - Andersson, Robin
AU - Bjerregaard, Peter
AU - Jørgensen, Marit Eika
AU - Albrechtsen, Anders
AU - Hansen, Torben
PY - 2018
Y1 - 2018
N2 - We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. These findings provide new information on disease etiology relevant for future treatment strategies.
AB - We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. These findings provide new information on disease etiology relevant for future treatment strategies.
U2 - 10.1038/s41588-017-0022-7
DO - 10.1038/s41588-017-0022-7
M3 - Journal article
C2 - 29311636
VL - 50
SP - 172
EP - 174
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 2
ER -
