Making bio-sense of toxicity: new developments in whole-cell biosencors

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Standard

Making bio-sense of toxicity: new developments in whole-cell biosencors. / Sørensen, Søren Johannes; Burmølle, Mette; Hansen, Lars Hestbjerg.

In: Current Opinion in Biotechnology, Vol. 17, No. 1, 2006, p. 11-16.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sørensen, SJ, Burmølle, M & Hansen, LH 2006, 'Making bio-sense of toxicity: new developments in whole-cell biosencors', Current Opinion in Biotechnology, vol. 17, no. 1, pp. 11-16. https://doi.org/10.1016/j.copbio.2005.12.007

APA

Sørensen, S. J., Burmølle, M., & Hansen, L. H. (2006). Making bio-sense of toxicity: new developments in whole-cell biosencors. Current Opinion in Biotechnology, 17(1), 11-16. https://doi.org/10.1016/j.copbio.2005.12.007

Vancouver

Sørensen SJ, Burmølle M, Hansen LH. Making bio-sense of toxicity: new developments in whole-cell biosencors. Current Opinion in Biotechnology. 2006;17(1):11-16. https://doi.org/10.1016/j.copbio.2005.12.007

Author

Sørensen, Søren Johannes ; Burmølle, Mette ; Hansen, Lars Hestbjerg. / Making bio-sense of toxicity: new developments in whole-cell biosencors. In: Current Opinion in Biotechnology. 2006 ; Vol. 17, No. 1. pp. 11-16.

Bibtex

@article{707b00f06c3811dcbee902004c4f4f50,
title = "Making bio-sense of toxicity: new developments in whole-cell biosencors",
abstract = "Bacterial whole-cell biosensors are very useful for toxicity measurements of various samples. Semi-specific biosensors, containing fusions of stress-regulated promoters and reporter genes, have several advantages over the traditional, general biosensors that are based on constitutively expressed reporter genes. Furthermore, semi-specific biosensors are constantly being refined to lower their sensitivity and, in combination, are able to detect a wide range of toxic agents. However, the requirement for a positive response of these biosensors to toxicants can result in false-negative responses. The application of in situ inoculation and single-cell detection, combined with the introduction of new reporter genes and refined detection equipment, could lead to the extensive use of semi-specific, stress-responsive biosensors for toxicity estimations in the future.",
author = "S{\o}rensen, {S{\o}ren Johannes} and Mette Burm{\o}lle and Hansen, {Lars Hestbjerg}",
year = "2006",
doi = "10.1016/j.copbio.2005.12.007",
language = "English",
volume = "17",
pages = "11--16",
journal = "Current Opinion in Biotechnology",
issn = "0958-1669",
publisher = "Elsevier Ltd. * Current Opinion Journals",
number = "1",

}

RIS

TY - JOUR

T1 - Making bio-sense of toxicity: new developments in whole-cell biosencors

AU - Sørensen, Søren Johannes

AU - Burmølle, Mette

AU - Hansen, Lars Hestbjerg

PY - 2006

Y1 - 2006

N2 - Bacterial whole-cell biosensors are very useful for toxicity measurements of various samples. Semi-specific biosensors, containing fusions of stress-regulated promoters and reporter genes, have several advantages over the traditional, general biosensors that are based on constitutively expressed reporter genes. Furthermore, semi-specific biosensors are constantly being refined to lower their sensitivity and, in combination, are able to detect a wide range of toxic agents. However, the requirement for a positive response of these biosensors to toxicants can result in false-negative responses. The application of in situ inoculation and single-cell detection, combined with the introduction of new reporter genes and refined detection equipment, could lead to the extensive use of semi-specific, stress-responsive biosensors for toxicity estimations in the future.

AB - Bacterial whole-cell biosensors are very useful for toxicity measurements of various samples. Semi-specific biosensors, containing fusions of stress-regulated promoters and reporter genes, have several advantages over the traditional, general biosensors that are based on constitutively expressed reporter genes. Furthermore, semi-specific biosensors are constantly being refined to lower their sensitivity and, in combination, are able to detect a wide range of toxic agents. However, the requirement for a positive response of these biosensors to toxicants can result in false-negative responses. The application of in situ inoculation and single-cell detection, combined with the introduction of new reporter genes and refined detection equipment, could lead to the extensive use of semi-specific, stress-responsive biosensors for toxicity estimations in the future.

U2 - 10.1016/j.copbio.2005.12.007

DO - 10.1016/j.copbio.2005.12.007

M3 - Journal article

C2 - 16376540

VL - 17

SP - 11

EP - 16

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

SN - 0958-1669

IS - 1

ER -

ID: 1122098