Metagenome-wide association of gut microbiome features for schizophrenia

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Metagenome-wide association of gut microbiome features for schizophrenia. / Zhu, Feng; Ju, Yanmei; Wang, Wei; Wang, Qi; Guo, Ruijin; Ma, Qingyan; Sun, Qiang; Fan, Yajuan; Xie, Yuying; Yang, Zai; Jie, Zhuye; Zhao, Binbin; Xiao, Liang; Yang, Lin; Zhang, Tao; Feng, Junqin; Guo, Liyang; He, Xiaoyan; Chen, Yunchun; Chen, Ce; Gao, Chengge; Xu, Xun; Yang, Huanming; Wang, Jian; Dang, Yonghui; Madsen, Lise; Brix, Susanne; Kristiansen, Karsten; Jia, Huijue; Ma, Xiancang.

In: Nature Communications, Vol. 11, 1612, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhu, F, Ju, Y, Wang, W, Wang, Q, Guo, R, Ma, Q, Sun, Q, Fan, Y, Xie, Y, Yang, Z, Jie, Z, Zhao, B, Xiao, L, Yang, L, Zhang, T, Feng, J, Guo, L, He, X, Chen, Y, Chen, C, Gao, C, Xu, X, Yang, H, Wang, J, Dang, Y, Madsen, L, Brix, S, Kristiansen, K, Jia, H & Ma, X 2020, 'Metagenome-wide association of gut microbiome features for schizophrenia', Nature Communications, vol. 11, 1612. https://doi.org/10.1038/s41467-020-15457-9

APA

Zhu, F., Ju, Y., Wang, W., Wang, Q., Guo, R., Ma, Q., Sun, Q., Fan, Y., Xie, Y., Yang, Z., Jie, Z., Zhao, B., Xiao, L., Yang, L., Zhang, T., Feng, J., Guo, L., He, X., Chen, Y., ... Ma, X. (2020). Metagenome-wide association of gut microbiome features for schizophrenia. Nature Communications, 11, [1612]. https://doi.org/10.1038/s41467-020-15457-9

Vancouver

Zhu F, Ju Y, Wang W, Wang Q, Guo R, Ma Q et al. Metagenome-wide association of gut microbiome features for schizophrenia. Nature Communications. 2020;11. 1612. https://doi.org/10.1038/s41467-020-15457-9

Author

Zhu, Feng ; Ju, Yanmei ; Wang, Wei ; Wang, Qi ; Guo, Ruijin ; Ma, Qingyan ; Sun, Qiang ; Fan, Yajuan ; Xie, Yuying ; Yang, Zai ; Jie, Zhuye ; Zhao, Binbin ; Xiao, Liang ; Yang, Lin ; Zhang, Tao ; Feng, Junqin ; Guo, Liyang ; He, Xiaoyan ; Chen, Yunchun ; Chen, Ce ; Gao, Chengge ; Xu, Xun ; Yang, Huanming ; Wang, Jian ; Dang, Yonghui ; Madsen, Lise ; Brix, Susanne ; Kristiansen, Karsten ; Jia, Huijue ; Ma, Xiancang. / Metagenome-wide association of gut microbiome features for schizophrenia. In: Nature Communications. 2020 ; Vol. 11.

Bibtex

@article{7d4058fd81654b7eb042c85a1475d322,
title = "Metagenome-wide association of gut microbiome features for schizophrenia",
abstract = "Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-na{\"i}ve patients are scarce hampering comprehensive analyses of the complex interaction between the gut microbiota and the brain. Here we explore the fecal microbiome based on 90 medication-free schizophrenia patients and 81 controls and identify a microbial species classifier distinguishing patients from controls with an area under the receiver operating characteristic curve (AUC) of 0.896, and replicate the microbiome-based disease classifier in 45 patients and 45 controls (AUC = 0.765). Functional potentials associated with schizophrenia include differences in short-chain fatty acids synthesis, tryptophan metabolism, and synthesis/degradation of neurotransmitters. Transplantation of a schizophrenia-enriched bacterium, Streptococcus vestibularis, appear to induces deficits in social behaviors, and alters neurotransmitter levels in peripheral tissues in recipient mice. Our findings provide new leads for further investigations in cohort studies and animal models.",
author = "Feng Zhu and Yanmei Ju and Wei Wang and Qi Wang and Ruijin Guo and Qingyan Ma and Qiang Sun and Yajuan Fan and Yuying Xie and Zai Yang and Zhuye Jie and Binbin Zhao and Liang Xiao and Lin Yang and Tao Zhang and Junqin Feng and Liyang Guo and Xiaoyan He and Yunchun Chen and Ce Chen and Chengge Gao and Xun Xu and Huanming Yang and Jian Wang and Yonghui Dang and Lise Madsen and Susanne Brix and Karsten Kristiansen and Huijue Jia and Xiancang Ma",
year = "2020",
doi = "10.1038/s41467-020-15457-9",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Metagenome-wide association of gut microbiome features for schizophrenia

AU - Zhu, Feng

AU - Ju, Yanmei

AU - Wang, Wei

AU - Wang, Qi

AU - Guo, Ruijin

AU - Ma, Qingyan

AU - Sun, Qiang

AU - Fan, Yajuan

AU - Xie, Yuying

AU - Yang, Zai

AU - Jie, Zhuye

AU - Zhao, Binbin

AU - Xiao, Liang

AU - Yang, Lin

AU - Zhang, Tao

AU - Feng, Junqin

AU - Guo, Liyang

AU - He, Xiaoyan

AU - Chen, Yunchun

AU - Chen, Ce

AU - Gao, Chengge

AU - Xu, Xun

AU - Yang, Huanming

AU - Wang, Jian

AU - Dang, Yonghui

AU - Madsen, Lise

AU - Brix, Susanne

AU - Kristiansen, Karsten

AU - Jia, Huijue

AU - Ma, Xiancang

PY - 2020

Y1 - 2020

N2 - Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-naïve patients are scarce hampering comprehensive analyses of the complex interaction between the gut microbiota and the brain. Here we explore the fecal microbiome based on 90 medication-free schizophrenia patients and 81 controls and identify a microbial species classifier distinguishing patients from controls with an area under the receiver operating characteristic curve (AUC) of 0.896, and replicate the microbiome-based disease classifier in 45 patients and 45 controls (AUC = 0.765). Functional potentials associated with schizophrenia include differences in short-chain fatty acids synthesis, tryptophan metabolism, and synthesis/degradation of neurotransmitters. Transplantation of a schizophrenia-enriched bacterium, Streptococcus vestibularis, appear to induces deficits in social behaviors, and alters neurotransmitter levels in peripheral tissues in recipient mice. Our findings provide new leads for further investigations in cohort studies and animal models.

AB - Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-naïve patients are scarce hampering comprehensive analyses of the complex interaction between the gut microbiota and the brain. Here we explore the fecal microbiome based on 90 medication-free schizophrenia patients and 81 controls and identify a microbial species classifier distinguishing patients from controls with an area under the receiver operating characteristic curve (AUC) of 0.896, and replicate the microbiome-based disease classifier in 45 patients and 45 controls (AUC = 0.765). Functional potentials associated with schizophrenia include differences in short-chain fatty acids synthesis, tryptophan metabolism, and synthesis/degradation of neurotransmitters. Transplantation of a schizophrenia-enriched bacterium, Streptococcus vestibularis, appear to induces deficits in social behaviors, and alters neurotransmitter levels in peripheral tissues in recipient mice. Our findings provide new leads for further investigations in cohort studies and animal models.

U2 - 10.1038/s41467-020-15457-9

DO - 10.1038/s41467-020-15457-9

M3 - Journal article

C2 - 32235826

AN - SCOPUS:85082791457

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 1612

ER -

ID: 239955767