mRNA Decapping Factors LSM1 and PAT Paralogs Are Involved in Turnip Mosaic Virus Viral Infection

Research output: Contribution to journal › Journal article › Research › peer-review

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mRNA Decapping Factors LSM1 and PAT Paralogs Are Involved in Turnip Mosaic Virus Viral Infection. / Zuo, Zhangli; Roux, Milena; Rodriguez, Eleazar; Petersen, Morten.

In: Molecular plant-microbe interactions : MPMI, Vol. 35, No. 2, 2022, p. 125-130.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zuo, Z, Roux, M, Rodriguez, E & Petersen, M 2022, 'mRNA Decapping Factors LSM1 and PAT Paralogs Are Involved in Turnip Mosaic Virus Viral Infection', Molecular plant-microbe interactions : MPMI, vol. 35, no. 2, pp. 125-130. https://doi.org/10.1094/MPMI-09-21-0220-SC

APA

Zuo, Z., Roux, M., Rodriguez, E., & Petersen, M. (2022). mRNA Decapping Factors LSM1 and PAT Paralogs Are Involved in Turnip Mosaic Virus Viral Infection. Molecular plant-microbe interactions : MPMI, 35(2), 125-130. https://doi.org/10.1094/MPMI-09-21-0220-SC

Vancouver

Zuo Z, Roux M, Rodriguez E, Petersen M. mRNA Decapping Factors LSM1 and PAT Paralogs Are Involved in Turnip Mosaic Virus Viral Infection. Molecular plant-microbe interactions : MPMI. 2022;35(2):125-130. https://doi.org/10.1094/MPMI-09-21-0220-SC

Author

Zuo, Zhangli ; Roux, Milena ; Rodriguez, Eleazar ; Petersen, Morten. / mRNA Decapping Factors LSM1 and PAT Paralogs Are Involved in Turnip Mosaic Virus Viral Infection. In: Molecular plant-microbe interactions : MPMI. 2022 ; Vol. 35, No. 2. pp. 125-130.

Bibtex

@article{fc2f62c6fcba45fdbac044feddbffc1f,
title = "mRNA Decapping Factors LSM1 and PAT Paralogs Are Involved in Turnip Mosaic Virus Viral Infection",
abstract = "Turnip mosaic virus is a devastating potyvirus infecting many economically important brassica crops. In response to this, the plant host engages its RNA silencing machinery, involving AGO proteins, as a prominent strategy to restrain turnip mosaic virus (TuMV) infection. It has also been shown that the mRNA decay components DCP2 and VCS partake in viral infection suppression. Here, we report that the mRNA decapping components LSM1, PAT1, PATH1, and PATH2 are essential for TuMV infection. More specifically, lsm1a/lsm1b double mutants and pat1/path1/path2 triple mutants in summ2 background exhibit resistance to TuMV. Concurrently, we observed that TuMV interferes with the decapping function of LSM1 and PAT proteins as the mRNA-decay target genes UGT87A2 and ASL9 accumulate during TuMV infection. Moreover, as TuMV coat protein can be specifically found in complexes with PAT proteins but not LSM1, this suggests that TuMV {"}hijacks{"} decapping components via PAT proteins to support viral infection.[Formula: see text]",
keywords = "LSM1, mRNA decapping, PAT paralogs, Turnip mosaic virus",
author = "Zhangli Zuo and Milena Roux and Eleazar Rodriguez and Morten Petersen",
year = "2022",
doi = "10.1094/MPMI-09-21-0220-SC",
language = "English",
volume = "35",
pages = "125--130",
journal = "Molecular Plant - Microbe Interactions",
issn = "0894-0282",
publisher = "American Phytopathological Society",
number = "2",

}

RIS

TY - JOUR

T1 - mRNA Decapping Factors LSM1 and PAT Paralogs Are Involved in Turnip Mosaic Virus Viral Infection

AU - Zuo, Zhangli

AU - Roux, Milena

AU - Rodriguez, Eleazar

AU - Petersen, Morten

PY - 2022

Y1 - 2022

N2 - Turnip mosaic virus is a devastating potyvirus infecting many economically important brassica crops. In response to this, the plant host engages its RNA silencing machinery, involving AGO proteins, as a prominent strategy to restrain turnip mosaic virus (TuMV) infection. It has also been shown that the mRNA decay components DCP2 and VCS partake in viral infection suppression. Here, we report that the mRNA decapping components LSM1, PAT1, PATH1, and PATH2 are essential for TuMV infection. More specifically, lsm1a/lsm1b double mutants and pat1/path1/path2 triple mutants in summ2 background exhibit resistance to TuMV. Concurrently, we observed that TuMV interferes with the decapping function of LSM1 and PAT proteins as the mRNA-decay target genes UGT87A2 and ASL9 accumulate during TuMV infection. Moreover, as TuMV coat protein can be specifically found in complexes with PAT proteins but not LSM1, this suggests that TuMV "hijacks" decapping components via PAT proteins to support viral infection.[Formula: see text]

AB - Turnip mosaic virus is a devastating potyvirus infecting many economically important brassica crops. In response to this, the plant host engages its RNA silencing machinery, involving AGO proteins, as a prominent strategy to restrain turnip mosaic virus (TuMV) infection. It has also been shown that the mRNA decay components DCP2 and VCS partake in viral infection suppression. Here, we report that the mRNA decapping components LSM1, PAT1, PATH1, and PATH2 are essential for TuMV infection. More specifically, lsm1a/lsm1b double mutants and pat1/path1/path2 triple mutants in summ2 background exhibit resistance to TuMV. Concurrently, we observed that TuMV interferes with the decapping function of LSM1 and PAT proteins as the mRNA-decay target genes UGT87A2 and ASL9 accumulate during TuMV infection. Moreover, as TuMV coat protein can be specifically found in complexes with PAT proteins but not LSM1, this suggests that TuMV "hijacks" decapping components via PAT proteins to support viral infection.[Formula: see text]

KW - LSM1

KW - mRNA decapping

KW - PAT paralogs

KW - Turnip mosaic virus

U2 - 10.1094/MPMI-09-21-0220-SC

DO - 10.1094/MPMI-09-21-0220-SC

M3 - Journal article

C2 - 35100808

AN - SCOPUS:85124797900

VL - 35

SP - 125

EP - 130

JO - Molecular Plant - Microbe Interactions

JF - Molecular Plant - Microbe Interactions

SN - 0894-0282

IS - 2

ER -

ID: 298737598