Mutation of miRNA target sequences during human evolution.

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Mutation of miRNA target sequences during human evolution. / Gardner, Paul P; Vinther, Jeppe.

In: Trends in Genetics, Vol. 24, No. 6, 2008, p. 262-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gardner, PP & Vinther, J 2008, 'Mutation of miRNA target sequences during human evolution.', Trends in Genetics, vol. 24, no. 6, pp. 262-5. https://doi.org/10.1016/j.tig.2008.03.009

APA

Gardner, P. P., & Vinther, J. (2008). Mutation of miRNA target sequences during human evolution. Trends in Genetics, 24(6), 262-5. https://doi.org/10.1016/j.tig.2008.03.009

Vancouver

Gardner PP, Vinther J. Mutation of miRNA target sequences during human evolution. Trends in Genetics. 2008;24(6):262-5. https://doi.org/10.1016/j.tig.2008.03.009

Author

Gardner, Paul P ; Vinther, Jeppe. / Mutation of miRNA target sequences during human evolution. In: Trends in Genetics. 2008 ; Vol. 24, No. 6. pp. 262-5.

Bibtex

@article{1966262049c611ddb7b4000ea68e967b,
title = "Mutation of miRNA target sequences during human evolution.",
abstract = "It has long-been hypothesized that changes in non-protein-coding genes and the regulatory sequences controlling expression could undergo positive selection. Here we identify 402 putative microRNA (miRNA) target sequences that have been mutated specifically in the human lineage and show that genes containing such deletions are more highly expressed than their mouse orthologs. Our findings indicate that some miRNA target mutations are fixed by positive selection and might have been involved in the evolution of human-specific traits.",
author = "Gardner, {Paul P} and Jeppe Vinther",
year = "2008",
doi = "10.1016/j.tig.2008.03.009",
language = "English",
volume = "24",
pages = "262--5",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Ltd. * Trends Journals",
number = "6",

}

RIS

TY - JOUR

T1 - Mutation of miRNA target sequences during human evolution.

AU - Gardner, Paul P

AU - Vinther, Jeppe

PY - 2008

Y1 - 2008

N2 - It has long-been hypothesized that changes in non-protein-coding genes and the regulatory sequences controlling expression could undergo positive selection. Here we identify 402 putative microRNA (miRNA) target sequences that have been mutated specifically in the human lineage and show that genes containing such deletions are more highly expressed than their mouse orthologs. Our findings indicate that some miRNA target mutations are fixed by positive selection and might have been involved in the evolution of human-specific traits.

AB - It has long-been hypothesized that changes in non-protein-coding genes and the regulatory sequences controlling expression could undergo positive selection. Here we identify 402 putative microRNA (miRNA) target sequences that have been mutated specifically in the human lineage and show that genes containing such deletions are more highly expressed than their mouse orthologs. Our findings indicate that some miRNA target mutations are fixed by positive selection and might have been involved in the evolution of human-specific traits.

U2 - 10.1016/j.tig.2008.03.009

DO - 10.1016/j.tig.2008.03.009

M3 - Journal article

C2 - 18472179

VL - 24

SP - 262

EP - 265

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 6

ER -

ID: 4874456