Natalamycin A, an ansamycin from a termite-associated Streptomyces sp.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Natalamycin A, an ansamycin from a termite-associated Streptomyces sp. / Kim, Ki Hyun; Ramadhar, Timothy R.; Beemelmanns, Christine; Cao, Shugeng; Thomas-Poulsen, Michael; Currie, Cameron R.; Clardy, Jon.

In: Chemical Science, Vol. 5, 2014, p. 4333-4338.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kim, KH, Ramadhar, TR, Beemelmanns, C, Cao, S, Thomas-Poulsen, M, Currie, CR & Clardy, J 2014, 'Natalamycin A, an ansamycin from a termite-associated Streptomyces sp.', Chemical Science, vol. 5, pp. 4333-4338. https://doi.org/10.1039/C4SC01136H

APA

Kim, K. H., Ramadhar, T. R., Beemelmanns, C., Cao, S., Thomas-Poulsen, M., Currie, C. R., & Clardy, J. (2014). Natalamycin A, an ansamycin from a termite-associated Streptomyces sp. Chemical Science, 5, 4333-4338. https://doi.org/10.1039/C4SC01136H

Vancouver

Kim KH, Ramadhar TR, Beemelmanns C, Cao S, Thomas-Poulsen M, Currie CR et al. Natalamycin A, an ansamycin from a termite-associated Streptomyces sp. Chemical Science. 2014;5:4333-4338. https://doi.org/10.1039/C4SC01136H

Author

Kim, Ki Hyun ; Ramadhar, Timothy R. ; Beemelmanns, Christine ; Cao, Shugeng ; Thomas-Poulsen, Michael ; Currie, Cameron R. ; Clardy, Jon. / Natalamycin A, an ansamycin from a termite-associated Streptomyces sp. In: Chemical Science. 2014 ; Vol. 5. pp. 4333-4338.

Bibtex

@article{3dd71d3468b6423ca2ec30cbcdad15c0,
title = "Natalamycin A, an ansamycin from a termite-associated Streptomyces sp.",
abstract = "We report a preliminary functional and complete structural characterization of a highly unusual geldanamycin analog, natalamycin A, that was isolated from Streptomyces strain M56 recovered from a South African nest of Macrotermes natalensis termites. Bioassay-guided fractionation based on antifungal activity led to the isolation of natalamycin A, and a combination of NMR spectroscopy and X-ray crystallographic analysis, including highly-accurate quantum-chemical NMR calculations on the largest and most conformationally-flexible system to date, revealed natalamycin A's three-dimensional solid- and solution-state structure. This structure along with the structures of related compounds isolated from the same source suggest a geldanamycin-like biosynthetic pathway with unusual post-PKS modifications.",
author = "Kim, {Ki Hyun} and Ramadhar, {Timothy R.} and Christine Beemelmanns and Shugeng Cao and Michael Thomas-Poulsen and Currie, {Cameron R.} and Jon Clardy",
year = "2014",
doi = "10.1039/C4SC01136H",
language = "English",
volume = "5",
pages = "4333--4338",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",

}

RIS

TY - JOUR

T1 - Natalamycin A, an ansamycin from a termite-associated Streptomyces sp.

AU - Kim, Ki Hyun

AU - Ramadhar, Timothy R.

AU - Beemelmanns, Christine

AU - Cao, Shugeng

AU - Thomas-Poulsen, Michael

AU - Currie, Cameron R.

AU - Clardy, Jon

PY - 2014

Y1 - 2014

N2 - We report a preliminary functional and complete structural characterization of a highly unusual geldanamycin analog, natalamycin A, that was isolated from Streptomyces strain M56 recovered from a South African nest of Macrotermes natalensis termites. Bioassay-guided fractionation based on antifungal activity led to the isolation of natalamycin A, and a combination of NMR spectroscopy and X-ray crystallographic analysis, including highly-accurate quantum-chemical NMR calculations on the largest and most conformationally-flexible system to date, revealed natalamycin A's three-dimensional solid- and solution-state structure. This structure along with the structures of related compounds isolated from the same source suggest a geldanamycin-like biosynthetic pathway with unusual post-PKS modifications.

AB - We report a preliminary functional and complete structural characterization of a highly unusual geldanamycin analog, natalamycin A, that was isolated from Streptomyces strain M56 recovered from a South African nest of Macrotermes natalensis termites. Bioassay-guided fractionation based on antifungal activity led to the isolation of natalamycin A, and a combination of NMR spectroscopy and X-ray crystallographic analysis, including highly-accurate quantum-chemical NMR calculations on the largest and most conformationally-flexible system to date, revealed natalamycin A's three-dimensional solid- and solution-state structure. This structure along with the structures of related compounds isolated from the same source suggest a geldanamycin-like biosynthetic pathway with unusual post-PKS modifications.

U2 - 10.1039/C4SC01136H

DO - 10.1039/C4SC01136H

M3 - Journal article

C2 - 25386334

VL - 5

SP - 4333

EP - 4338

JO - Chemical Science

JF - Chemical Science

SN - 2041-6520

ER -

ID: 136190318