Natural products from actinobacteria associated with fungus-growing termites

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Standard

Natural products from actinobacteria associated with fungus-growing termites. / Benndorf, René; Guo, Huijuan; Sommerwerk, Elisabeth; Weigel, Christiane; Garcia-Altares, Maria; Martin, Karin; Hu, Haofu; Küfner, Michelle; de Beer, Z. Wilhelm; Poulsen, Michael; Beemelmanns, Christine.

In: Antibiotics, Vol. 7, No. 3, 83, 2018, p. 1-25.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Benndorf, R, Guo, H, Sommerwerk, E, Weigel, C, Garcia-Altares, M, Martin, K, Hu, H, Küfner, M, de Beer, ZW, Poulsen, M & Beemelmanns, C 2018, 'Natural products from actinobacteria associated with fungus-growing termites', Antibiotics, vol. 7, no. 3, 83, pp. 1-25. https://doi.org/10.3390/antibiotics7030083

APA

Benndorf, R., Guo, H., Sommerwerk, E., Weigel, C., Garcia-Altares, M., Martin, K., Hu, H., Küfner, M., de Beer, Z. W., Poulsen, M., & Beemelmanns, C. (2018). Natural products from actinobacteria associated with fungus-growing termites. Antibiotics, 7(3), 1-25. [83]. https://doi.org/10.3390/antibiotics7030083

Vancouver

Benndorf R, Guo H, Sommerwerk E, Weigel C, Garcia-Altares M, Martin K et al. Natural products from actinobacteria associated with fungus-growing termites. Antibiotics. 2018;7(3):1-25. 83. https://doi.org/10.3390/antibiotics7030083

Author

Benndorf, René ; Guo, Huijuan ; Sommerwerk, Elisabeth ; Weigel, Christiane ; Garcia-Altares, Maria ; Martin, Karin ; Hu, Haofu ; Küfner, Michelle ; de Beer, Z. Wilhelm ; Poulsen, Michael ; Beemelmanns, Christine. / Natural products from actinobacteria associated with fungus-growing termites. In: Antibiotics. 2018 ; Vol. 7, No. 3. pp. 1-25.

Bibtex

@article{bd7d26c062284e72bba92d9013d9c3da,
title = "Natural products from actinobacteria associated with fungus-growing termites",
abstract = "The chemical analysis of insect-associated Actinobacteria has attracted the interest of natural product chemists in the past years as bacterial-produced metabolites are sought to be crucial for sustaining and protecting the insect host. The objective of our study was to evaluate the phylogeny and bioprospecting of Actinobacteria associated with fungus-growing termites. We characterized 97 Actinobacteria from the gut, exoskeleton, and fungus garden (comb) of the fungus-growing termite Macrotermes natalensis and used two different bioassays to assess their general antimicrobial activity. We selected two strains for chemical analysis and investigated the culture broth of the axenic strains and fungus-actinobacterium co-cultures. From these studies, we identified the previously-reported PKS-derived barceloneic acid A and the PKS-derived rubterolones. Analysis of culture broth yielded a new dichlorinated diketopiperazine derivative and two new tetracyclic lanthipeptides, named rubrominins A and B. The discussed natural products highlight that insect-associated Actinobacteria are highly prolific natural product producers yielding important chemical scaffolds urgently needed for future drug development programs.",
keywords = "Actinobacteria, Chemical ecology, Drug discovery, Secondary metabolites, Symbiosis",
author = "Ren{\'e} Benndorf and Huijuan Guo and Elisabeth Sommerwerk and Christiane Weigel and Maria Garcia-Altares and Karin Martin and Haofu Hu and Michelle K{\"u}fner and {de Beer}, {Z. Wilhelm} and Michael Poulsen and Christine Beemelmanns",
year = "2018",
doi = "10.3390/antibiotics7030083",
language = "English",
volume = "7",
pages = "1--25",
journal = "Antibiotics",
issn = "2079-6382",
publisher = "M D P I AG",
number = "3",

}

RIS

TY - JOUR

T1 - Natural products from actinobacteria associated with fungus-growing termites

AU - Benndorf, René

AU - Guo, Huijuan

AU - Sommerwerk, Elisabeth

AU - Weigel, Christiane

AU - Garcia-Altares, Maria

AU - Martin, Karin

AU - Hu, Haofu

AU - Küfner, Michelle

AU - de Beer, Z. Wilhelm

AU - Poulsen, Michael

AU - Beemelmanns, Christine

PY - 2018

Y1 - 2018

N2 - The chemical analysis of insect-associated Actinobacteria has attracted the interest of natural product chemists in the past years as bacterial-produced metabolites are sought to be crucial for sustaining and protecting the insect host. The objective of our study was to evaluate the phylogeny and bioprospecting of Actinobacteria associated with fungus-growing termites. We characterized 97 Actinobacteria from the gut, exoskeleton, and fungus garden (comb) of the fungus-growing termite Macrotermes natalensis and used two different bioassays to assess their general antimicrobial activity. We selected two strains for chemical analysis and investigated the culture broth of the axenic strains and fungus-actinobacterium co-cultures. From these studies, we identified the previously-reported PKS-derived barceloneic acid A and the PKS-derived rubterolones. Analysis of culture broth yielded a new dichlorinated diketopiperazine derivative and two new tetracyclic lanthipeptides, named rubrominins A and B. The discussed natural products highlight that insect-associated Actinobacteria are highly prolific natural product producers yielding important chemical scaffolds urgently needed for future drug development programs.

AB - The chemical analysis of insect-associated Actinobacteria has attracted the interest of natural product chemists in the past years as bacterial-produced metabolites are sought to be crucial for sustaining and protecting the insect host. The objective of our study was to evaluate the phylogeny and bioprospecting of Actinobacteria associated with fungus-growing termites. We characterized 97 Actinobacteria from the gut, exoskeleton, and fungus garden (comb) of the fungus-growing termite Macrotermes natalensis and used two different bioassays to assess their general antimicrobial activity. We selected two strains for chemical analysis and investigated the culture broth of the axenic strains and fungus-actinobacterium co-cultures. From these studies, we identified the previously-reported PKS-derived barceloneic acid A and the PKS-derived rubterolones. Analysis of culture broth yielded a new dichlorinated diketopiperazine derivative and two new tetracyclic lanthipeptides, named rubrominins A and B. The discussed natural products highlight that insect-associated Actinobacteria are highly prolific natural product producers yielding important chemical scaffolds urgently needed for future drug development programs.

KW - Actinobacteria

KW - Chemical ecology

KW - Drug discovery

KW - Secondary metabolites

KW - Symbiosis

U2 - 10.3390/antibiotics7030083

DO - 10.3390/antibiotics7030083

M3 - Journal article

C2 - 30217010

AN - SCOPUS:85055323535

VL - 7

SP - 1

EP - 25

JO - Antibiotics

JF - Antibiotics

SN - 2079-6382

IS - 3

M1 - 83

ER -

ID: 204423324