Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy
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Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1 : similarities, differences, and implications for cancer therapy. / Bødtkjer, Ebbe; Bunch, Lennart; Pedersen, Stine Helene Falsig.
In: Current Pharmaceutical Design, Vol. 18, No. 10, 2012, p. 1345-1371.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1
T2 - similarities, differences, and implications for cancer therapy
AU - Bødtkjer, Ebbe
AU - Bunch, Lennart
AU - Pedersen, Stine Helene Falsig
PY - 2012
Y1 - 2012
N2 - The Na+/H+-exchanger 1, NHE1 (SLC9A1) and the electroneutral Na+, HCO3--cotransporter NBCn1 (SLC4A7) are co-expressed in a wide range of tissues. Under normal physiological conditions these transporters play an ostensibly similar role, namely that of net acid extrusion after cellular acidification. In addition, they have been implicated in multiple other cellular processes, including regulation of transepithelial transport, cell volume, cell death/survival balance, and cell motility. In spite of their apparent functional similarity, the two transporters also serve distinctly different functions and are differentially regulated. Here, we provide an update on the basic structure, function, regulation, physiology and pharmacology of NHE1 and NBCn1, with particular focus on the factors responsible for their functional similarities and differences. Finally, we highlight recent findings implicating these transporters in cancer development, and discuss issues relating to NHE1 and NBCn1 as potential targets in cancer treatment.
AB - The Na+/H+-exchanger 1, NHE1 (SLC9A1) and the electroneutral Na+, HCO3--cotransporter NBCn1 (SLC4A7) are co-expressed in a wide range of tissues. Under normal physiological conditions these transporters play an ostensibly similar role, namely that of net acid extrusion after cellular acidification. In addition, they have been implicated in multiple other cellular processes, including regulation of transepithelial transport, cell volume, cell death/survival balance, and cell motility. In spite of their apparent functional similarity, the two transporters also serve distinctly different functions and are differentially regulated. Here, we provide an update on the basic structure, function, regulation, physiology and pharmacology of NHE1 and NBCn1, with particular focus on the factors responsible for their functional similarities and differences. Finally, we highlight recent findings implicating these transporters in cancer development, and discuss issues relating to NHE1 and NBCn1 as potential targets in cancer treatment.
M3 - Journal article
VL - 18
SP - 1345
EP - 1371
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
SN - 1381-6128
IS - 10
ER -
ID: 41878309