Platypus and echidna genomes reveal mammalian biology and evolution
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Platypus and echidna genomes reveal mammalian biology and evolution. / Zhou, Yang; Shearwin-Whyatt, Linda; Li, Jing; Song, Zhenzhen; Hayakawa, Takashi; Stevens, David; Fenelon, Jane C.; Peel, Emma; Cheng, Yuanyuan; Pajpach, Filip; Bradley, Natasha; Suzuki, Hikoyu; Nikaido, Masato; Damas, Joana; Daish, Tasman; Perry, Tahlia; Zhu, Zexian; Geng, Yuncong; Rhie, Arang; Sims, Ying; Wood, Jonathan; Haase, Bettina; Mountcastle, Jacquelyn; Fedrigo, Olivier; Li, Qiye; Yang, Huanming; Wang, Jian; Johnston, Stephen D.; Phillippy, Adam M.; Howe, Kerstin; Jarvis, Erich D.; Ryder, Oliver A.; Kaessmann, Henrik; Donnelly, Peter; Korlach, Jonas; Lewin, Harris A.; Graves, Jennifer; Belov, Katherine; Renfree, Marilyn B.; Grutzner, Frank; Zhou, Qi; Zhang, Guojie.
In: Nature, Vol. 592, No. 7856, 2021, p. 756-762.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Platypus and echidna genomes reveal mammalian biology and evolution
AU - Zhou, Yang
AU - Shearwin-Whyatt, Linda
AU - Li, Jing
AU - Song, Zhenzhen
AU - Hayakawa, Takashi
AU - Stevens, David
AU - Fenelon, Jane C.
AU - Peel, Emma
AU - Cheng, Yuanyuan
AU - Pajpach, Filip
AU - Bradley, Natasha
AU - Suzuki, Hikoyu
AU - Nikaido, Masato
AU - Damas, Joana
AU - Daish, Tasman
AU - Perry, Tahlia
AU - Zhu, Zexian
AU - Geng, Yuncong
AU - Rhie, Arang
AU - Sims, Ying
AU - Wood, Jonathan
AU - Haase, Bettina
AU - Mountcastle, Jacquelyn
AU - Fedrigo, Olivier
AU - Li, Qiye
AU - Yang, Huanming
AU - Wang, Jian
AU - Johnston, Stephen D.
AU - Phillippy, Adam M.
AU - Howe, Kerstin
AU - Jarvis, Erich D.
AU - Ryder, Oliver A.
AU - Kaessmann, Henrik
AU - Donnelly, Peter
AU - Korlach, Jonas
AU - Lewin, Harris A.
AU - Graves, Jennifer
AU - Belov, Katherine
AU - Renfree, Marilyn B.
AU - Grutzner, Frank
AU - Zhou, Qi
AU - Zhang, Guojie
PY - 2021
Y1 - 2021
N2 - Egg-laying mammals (monotremes) are the only extant mammalian outgroup to therians (marsupial and eutherian animals) and provide key insights into mammalian evolution1,2. Here we generate and analyse reference genomes of the platypus (Ornithorhynchus anatinus) and echidna (Tachyglossus aculeatus), which represent the only two extant monotreme lineages. The nearly complete platypus genome assembly has anchored almost the entire genome onto chromosomes, markedly improving the genome continuity and gene annotation. Together with our echidna sequence, the genomes of the two species allow us to detect the ancestral and lineage-specific genomic changes that shape both monotreme and mammalian evolution. We provide evidence that the monotreme sex chromosome complex originated from an ancestral chromosome ring configuration. The formation of such a unique chromosome complex may have been facilitated by the unusually extensive interactions between the multi-X and multi-Y chromosomes that are shared by the autosomal homologues in humans. Further comparative genomic analyses unravel marked differences between monotremes and therians in haptoglobin genes, lactation genes and chemosensory receptor genes for smell and taste that underlie the ecological adaptation of monotremes.
AB - Egg-laying mammals (monotremes) are the only extant mammalian outgroup to therians (marsupial and eutherian animals) and provide key insights into mammalian evolution1,2. Here we generate and analyse reference genomes of the platypus (Ornithorhynchus anatinus) and echidna (Tachyglossus aculeatus), which represent the only two extant monotreme lineages. The nearly complete platypus genome assembly has anchored almost the entire genome onto chromosomes, markedly improving the genome continuity and gene annotation. Together with our echidna sequence, the genomes of the two species allow us to detect the ancestral and lineage-specific genomic changes that shape both monotreme and mammalian evolution. We provide evidence that the monotreme sex chromosome complex originated from an ancestral chromosome ring configuration. The formation of such a unique chromosome complex may have been facilitated by the unusually extensive interactions between the multi-X and multi-Y chromosomes that are shared by the autosomal homologues in humans. Further comparative genomic analyses unravel marked differences between monotremes and therians in haptoglobin genes, lactation genes and chemosensory receptor genes for smell and taste that underlie the ecological adaptation of monotremes.
U2 - 10.1038/s41586-020-03039-0
DO - 10.1038/s41586-020-03039-0
M3 - Journal article
C2 - 33408411
AN - SCOPUS:85099236489
VL - 592
SP - 756
EP - 762
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7856
ER -
ID: 255551331