Proof of region-specific multipotent progenitors in human breast epithelia

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Proof of region-specific multipotent progenitors in human breast epithelia. / Fridriksdottir, Agla J; Villadsen, René; Morsing, Mikkel; Klitgaard, Marie Christine; Kim, Jiyoung; Petersen, Ole William; Rønnov-Jessen, Lone.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 47, 2017, p. E10102–E10111.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fridriksdottir, AJ, Villadsen, R, Morsing, M, Klitgaard, MC, Kim, J, Petersen, OW & Rønnov-Jessen, L 2017, 'Proof of region-specific multipotent progenitors in human breast epithelia', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 47, pp. E10102–E10111. https://doi.org/10.1073/pnas.1714063114

APA

Fridriksdottir, A. J., Villadsen, R., Morsing, M., Klitgaard, M. C., Kim, J., Petersen, O. W., & Rønnov-Jessen, L. (2017). Proof of region-specific multipotent progenitors in human breast epithelia. Proceedings of the National Academy of Sciences of the United States of America, 114(47), E10102–E10111. https://doi.org/10.1073/pnas.1714063114

Vancouver

Fridriksdottir AJ, Villadsen R, Morsing M, Klitgaard MC, Kim J, Petersen OW et al. Proof of region-specific multipotent progenitors in human breast epithelia. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(47):E10102–E10111. https://doi.org/10.1073/pnas.1714063114

Author

Fridriksdottir, Agla J ; Villadsen, René ; Morsing, Mikkel ; Klitgaard, Marie Christine ; Kim, Jiyoung ; Petersen, Ole William ; Rønnov-Jessen, Lone. / Proof of region-specific multipotent progenitors in human breast epithelia. In: Proceedings of the National Academy of Sciences of the United States of America. 2017 ; Vol. 114, No. 47. pp. E10102–E10111.

Bibtex

@article{4f1fec95ffc2449581ea55fba1bd1310,

title = "Proof of region-specific multipotent progenitors in human breast epithelia",

abstract = "The human breast parenchyma consists of collecting ducts and terminal duct lobular units (TDLUs). The TDLU is the site of origin of most breast cancers. The reason for such focal susceptibility to cancer remains poorly understood. Here, we take advantage of a region-specific heterogeneity in luminal progenitors to interrogate the differentiation repertoire of candidate stem cells in TDLUs. We show that stem-like activity in serial passage culture and in vivo breast morphogenesis relies on the preservation of a myoepithelial phenotype. By enrichment for region-specific progenitors, we identify bipotent and multipotent progenitors in ducts and TDLUs, respectively. We propose that focal breast cancer susceptibility, at least in part, originates from region-specific myoepithelial progenitors.",

keywords = "Journal Article",

author = "Fridriksdottir, {Agla J} and Ren{\'e} Villadsen and Mikkel Morsing and Klitgaard, {Marie Christine} and Jiyoung Kim and Petersen, {Ole William} and Lone R{\o}nnov-Jessen",

note = "Copyright {\textcopyright} 2017 the Author(s). Published by PNAS.",

year = "2017",

doi = "10.1073/pnas.1714063114",

language = "English",

volume = "114",

pages = "E10102–E10111",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "The National Academy of Sciences of the United States of America",

number = "47",

}

RIS

TY - JOUR

T1 - Proof of region-specific multipotent progenitors in human breast epithelia

AU - Fridriksdottir, Agla J

AU - Villadsen, René

AU - Morsing, Mikkel

AU - Klitgaard, Marie Christine

AU - Kim, Jiyoung

AU - Petersen, Ole William

AU - Rønnov-Jessen, Lone

PY - 2017

Y1 - 2017

N2 - The human breast parenchyma consists of collecting ducts and terminal duct lobular units (TDLUs). The TDLU is the site of origin of most breast cancers. The reason for such focal susceptibility to cancer remains poorly understood. Here, we take advantage of a region-specific heterogeneity in luminal progenitors to interrogate the differentiation repertoire of candidate stem cells in TDLUs. We show that stem-like activity in serial passage culture and in vivo breast morphogenesis relies on the preservation of a myoepithelial phenotype. By enrichment for region-specific progenitors, we identify bipotent and multipotent progenitors in ducts and TDLUs, respectively. We propose that focal breast cancer susceptibility, at least in part, originates from region-specific myoepithelial progenitors.

AB - The human breast parenchyma consists of collecting ducts and terminal duct lobular units (TDLUs). The TDLU is the site of origin of most breast cancers. The reason for such focal susceptibility to cancer remains poorly understood. Here, we take advantage of a region-specific heterogeneity in luminal progenitors to interrogate the differentiation repertoire of candidate stem cells in TDLUs. We show that stem-like activity in serial passage culture and in vivo breast morphogenesis relies on the preservation of a myoepithelial phenotype. By enrichment for region-specific progenitors, we identify bipotent and multipotent progenitors in ducts and TDLUs, respectively. We propose that focal breast cancer susceptibility, at least in part, originates from region-specific myoepithelial progenitors.

KW - Journal Article

U2 - 10.1073/pnas.1714063114

DO - 10.1073/pnas.1714063114

M3 - Journal article

C2 - 29109259

VL - 114

SP - E10102–E10111

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 47

ER -

ID: 185907971

Department of Biology