Purinergic signalling in the pancreas in health and disease

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Purinergic signalling in the pancreas in health and disease. / Burnstock, G; Novak, I.

In: Journal of Endocrinology, Vol. 213, No. 2, 2012, p. 123-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Burnstock, G & Novak, I 2012, 'Purinergic signalling in the pancreas in health and disease', Journal of Endocrinology, vol. 213, no. 2, pp. 123-41. https://doi.org/10.1530/JOE-11-0434

APA

Burnstock, G., & Novak, I. (2012). Purinergic signalling in the pancreas in health and disease. Journal of Endocrinology, 213(2), 123-41. https://doi.org/10.1530/JOE-11-0434

Vancouver

Burnstock G, Novak I. Purinergic signalling in the pancreas in health and disease. Journal of Endocrinology. 2012;213(2):123-41. https://doi.org/10.1530/JOE-11-0434

Author

Burnstock, G ; Novak, I. / Purinergic signalling in the pancreas in health and disease. In: Journal of Endocrinology. 2012 ; Vol. 213, No. 2. pp. 123-41.

Bibtex

@article{66ee10f1d99b4815b6683d1df08c3ec6,
title = "Purinergic signalling in the pancreas in health and disease",
abstract = "Pancreatic cells contain specialised stores for ATP. Purinergic receptors (P2 and P1) and ecto-nucleotidases are expressed in both endocrine and exocrine calls, as well as in stromal cells. The pancreas, especially the endocrine cells, were an early target for the actions of ATP. After the historical perspective of purinergic signalling in the pancreas, the focus of this review will be the physiological functions of purinergic signalling in the regulation of both endocrine and exocrine pancreas. Next, we will consider possible interaction between purinergic signalling and other regulatory systems and their relation to nutrient homeostasis and cell survival. The pancreas is an organ exhibiting several serious diseases - cystic fibrosis, pancreatitis, pancreatic cancer and diabetes - and some are associated with changes in life-style and are increasing in incidence. There is upcoming evidence for the role of purinergic signalling in the pathophysiology of the pancreas, and the new challenge is to understand how it is integrated with other pathological processes.",
keywords = "5'-Nucleotidase, Acinar Cells, Adenosine Triphosphate, Cystic Fibrosis, Diabetes Mellitus, Homeostasis, Humans, Insulin-Secreting Cells, Pancreas, Pancreas, Exocrine, Pancreatic Neoplasms, Pancreatic Stellate Cells, Pancreatitis, Receptors, Purinergic, Signal Transduction",
author = "G Burnstock and I Novak",
year = "2012",
doi = "10.1530/JOE-11-0434",
language = "English",
volume = "213",
pages = "123--41",
journal = "Journal of Endocrinology",
issn = "0022-0795",
publisher = "BioScientifica Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Purinergic signalling in the pancreas in health and disease

AU - Burnstock, G

AU - Novak, I

PY - 2012

Y1 - 2012

N2 - Pancreatic cells contain specialised stores for ATP. Purinergic receptors (P2 and P1) and ecto-nucleotidases are expressed in both endocrine and exocrine calls, as well as in stromal cells. The pancreas, especially the endocrine cells, were an early target for the actions of ATP. After the historical perspective of purinergic signalling in the pancreas, the focus of this review will be the physiological functions of purinergic signalling in the regulation of both endocrine and exocrine pancreas. Next, we will consider possible interaction between purinergic signalling and other regulatory systems and their relation to nutrient homeostasis and cell survival. The pancreas is an organ exhibiting several serious diseases - cystic fibrosis, pancreatitis, pancreatic cancer and diabetes - and some are associated with changes in life-style and are increasing in incidence. There is upcoming evidence for the role of purinergic signalling in the pathophysiology of the pancreas, and the new challenge is to understand how it is integrated with other pathological processes.

AB - Pancreatic cells contain specialised stores for ATP. Purinergic receptors (P2 and P1) and ecto-nucleotidases are expressed in both endocrine and exocrine calls, as well as in stromal cells. The pancreas, especially the endocrine cells, were an early target for the actions of ATP. After the historical perspective of purinergic signalling in the pancreas, the focus of this review will be the physiological functions of purinergic signalling in the regulation of both endocrine and exocrine pancreas. Next, we will consider possible interaction between purinergic signalling and other regulatory systems and their relation to nutrient homeostasis and cell survival. The pancreas is an organ exhibiting several serious diseases - cystic fibrosis, pancreatitis, pancreatic cancer and diabetes - and some are associated with changes in life-style and are increasing in incidence. There is upcoming evidence for the role of purinergic signalling in the pathophysiology of the pancreas, and the new challenge is to understand how it is integrated with other pathological processes.

KW - 5'-Nucleotidase

KW - Acinar Cells

KW - Adenosine Triphosphate

KW - Cystic Fibrosis

KW - Diabetes Mellitus

KW - Homeostasis

KW - Humans

KW - Insulin-Secreting Cells

KW - Pancreas

KW - Pancreas, Exocrine

KW - Pancreatic Neoplasms

KW - Pancreatic Stellate Cells

KW - Pancreatitis

KW - Receptors, Purinergic

KW - Signal Transduction

U2 - 10.1530/JOE-11-0434

DO - 10.1530/JOE-11-0434

M3 - Journal article

C2 - 22396456

VL - 213

SP - 123

EP - 141

JO - Journal of Endocrinology

JF - Journal of Endocrinology

SN - 0022-0795

IS - 2

ER -

ID: 43855310