Quantitative regulation of alternative splicing in evolution and development
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Quantitative regulation of alternative splicing in evolution and development. / Irimia, Manuel; Rukov, Jakob L; Roy, Scott W; Vinther, Jeppe; Garcia-Fernandez, Jordi.
In: BioEssays, Vol. 31, No. 1, 2009, p. 40-50.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Quantitative regulation of alternative splicing in evolution and development
AU - Irimia, Manuel
AU - Rukov, Jakob L
AU - Roy, Scott W
AU - Vinther, Jeppe
AU - Garcia-Fernandez, Jordi
N1 - Keywords alternative splicing • evo-devo • post-transcriptional regulation • transcriptome diversity
PY - 2009
Y1 - 2009
N2 - Alternative splicing (AS) is a widespread mechanism with an important role in increasing transcriptome and proteome diversity by generating multiple different products from the same gene. Evolutionary studies of AS have focused primarily on the conservation of alternatively spliced sequences or of the AS pattern of those sequences itself. Less is known about the evolution of the regulation of AS, but several studies, working from different perspectives, have recently made significant progress. Here, we categorize the different levels of AS evolution, and summarize the studies on evolution of AS regulation, which point to a high level of evolutionary conservation of the regulation of AS events conserved between related species. This suggests that the quantitative regulation of AS is an intrinsic part of AS function. We discuss the potential role of changes in developmental regulation of AS as an additional layer in complex gene regulatory networks and in the emergence of genetic novelties.
AB - Alternative splicing (AS) is a widespread mechanism with an important role in increasing transcriptome and proteome diversity by generating multiple different products from the same gene. Evolutionary studies of AS have focused primarily on the conservation of alternatively spliced sequences or of the AS pattern of those sequences itself. Less is known about the evolution of the regulation of AS, but several studies, working from different perspectives, have recently made significant progress. Here, we categorize the different levels of AS evolution, and summarize the studies on evolution of AS regulation, which point to a high level of evolutionary conservation of the regulation of AS events conserved between related species. This suggests that the quantitative regulation of AS is an intrinsic part of AS function. We discuss the potential role of changes in developmental regulation of AS as an additional layer in complex gene regulatory networks and in the emergence of genetic novelties.
U2 - 10.1002/bies.080092
DO - 10.1002/bies.080092
M3 - Journal article
C2 - 19154001
VL - 31
SP - 40
EP - 50
JO - BioEssays
JF - BioEssays
SN - 0265-9247
IS - 1
ER -
ID: 11231699