Reducing the rate of psychiatric re-admissions in bipolar disorder using smartphones - The RADMIS trial

Research output: Contribution to journalJournal articlepeer-review

Standard

Reducing the rate of psychiatric re-admissions in bipolar disorder using smartphones - The RADMIS trial. / Faurholt-Jepsen, Maria; Lindbjerg Tønning, Morten; Fros, Mads; Martiny, Klaus; Tuxen, Nanna; Rosenberg, Nicole; Busk, Jonas; Winther, Ole; Thaysen-Petersen, Daniel; Aamund, Kate Andreasson; Tolderlund, Lizzie; Bardram, Jakob Eyvind; Kessing, Lars Vedel.

In: Acta Psychiatrica Scandinavica, Vol. 143, No. 5, 2021, p. 453-465.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Faurholt-Jepsen, M, Lindbjerg Tønning, M, Fros, M, Martiny, K, Tuxen, N, Rosenberg, N, Busk, J, Winther, O, Thaysen-Petersen, D, Aamund, KA, Tolderlund, L, Bardram, JE & Kessing, LV 2021, 'Reducing the rate of psychiatric re-admissions in bipolar disorder using smartphones - The RADMIS trial', Acta Psychiatrica Scandinavica, vol. 143, no. 5, pp. 453-465. https://doi.org/10.1111/acps.13274

APA

Faurholt-Jepsen, M., Lindbjerg Tønning, M., Fros, M., Martiny, K., Tuxen, N., Rosenberg, N., Busk, J., Winther, O., Thaysen-Petersen, D., Aamund, K. A., Tolderlund, L., Bardram, J. E., & Kessing, L. V. (2021). Reducing the rate of psychiatric re-admissions in bipolar disorder using smartphones - The RADMIS trial. Acta Psychiatrica Scandinavica, 143(5), 453-465. https://doi.org/10.1111/acps.13274

Vancouver

Faurholt-Jepsen M, Lindbjerg Tønning M, Fros M, Martiny K, Tuxen N, Rosenberg N et al. Reducing the rate of psychiatric re-admissions in bipolar disorder using smartphones - The RADMIS trial. Acta Psychiatrica Scandinavica. 2021;143(5):453-465. https://doi.org/10.1111/acps.13274

Author

Faurholt-Jepsen, Maria ; Lindbjerg Tønning, Morten ; Fros, Mads ; Martiny, Klaus ; Tuxen, Nanna ; Rosenberg, Nicole ; Busk, Jonas ; Winther, Ole ; Thaysen-Petersen, Daniel ; Aamund, Kate Andreasson ; Tolderlund, Lizzie ; Bardram, Jakob Eyvind ; Kessing, Lars Vedel. / Reducing the rate of psychiatric re-admissions in bipolar disorder using smartphones - The RADMIS trial. In: Acta Psychiatrica Scandinavica. 2021 ; Vol. 143, No. 5. pp. 453-465.

Bibtex

@article{283e3be9150d4195838e7ff943ffddc7,
title = "Reducing the rate of psychiatric re-admissions in bipolar disorder using smartphones - The RADMIS trial",
abstract = "Objectives: The MONARCA I and II trials were negative but suggested that smartphone-based monitoring may increase quality of life and reduce perceived stress in bipolar disorder (BD). The present trial was the first to investigate the effect of smartphone-based monitoring on the rate and duration of readmissions in BD. Methods: This was a randomized controlled single-blind parallel-group trial. Patients with BD (ICD-10) discharged from hospitalization in the Mental Health Services, Capital Region of Denmark were randomized 1:1 to daily smartphone-based monitoring including a feedback loop (+ standard treatment) or to standard treatment for 6 months. Primary outcomes: the rate and duration of psychiatric readmissions. Results: We included 98 patients with BD. In ITT analyses, there was no statistically significant difference in rates (hazard rate: 1.05, 95% CI: 0.54; 1.91, p = 0.88) or duration of readmission between the two groups (B: 3.67, 95% CI: −4.77; 12.11, p = 0.39). There was no difference in scores on the Hamilton Depression Rating Scale (B = −0.11, 95% CI: −2.50; 2.29, p = 0.93). The intervention group had higher scores on the Young Mania Rating Scale (B: 1.89, 95% CI: 0.0078; 3.78, p = 0.050). The intervention group reported lower levels of perceived stress (B: -7.18, 95% CI: −13.50; −0.86, p = 0.026) and lower levels of rumination (B: −6.09, 95% CI: −11.19; −1.00, p = 0.019). Conclusions: Smartphone-based monitoring did not reduce rate and duration of readmissions. There was no difference in levels of depressive symptoms. The intervention group had higher levels of manic symptoms, but lower perceived stress and rumination compared with the control group.",
keywords = "bipolar disorder, RADMIS, randomized controlled trial, readmission, smartphone, the Monsenso system",
author = "Maria Faurholt-Jepsen and {Lindbjerg T{\o}nning}, Morten and Mads Fros and Klaus Martiny and Nanna Tuxen and Nicole Rosenberg and Jonas Busk and Ole Winther and Daniel Thaysen-Petersen and Aamund, {Kate Andreasson} and Lizzie Tolderlund and Bardram, {Jakob Eyvind} and Kessing, {Lars Vedel}",
year = "2021",
doi = "10.1111/acps.13274",
language = "English",
volume = "143",
pages = "453--465",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley",
number = "5",

}

RIS

TY - JOUR

T1 - Reducing the rate of psychiatric re-admissions in bipolar disorder using smartphones - The RADMIS trial

AU - Faurholt-Jepsen, Maria

AU - Lindbjerg Tønning, Morten

AU - Fros, Mads

AU - Martiny, Klaus

AU - Tuxen, Nanna

AU - Rosenberg, Nicole

AU - Busk, Jonas

AU - Winther, Ole

AU - Thaysen-Petersen, Daniel

AU - Aamund, Kate Andreasson

AU - Tolderlund, Lizzie

AU - Bardram, Jakob Eyvind

AU - Kessing, Lars Vedel

PY - 2021

Y1 - 2021

N2 - Objectives: The MONARCA I and II trials were negative but suggested that smartphone-based monitoring may increase quality of life and reduce perceived stress in bipolar disorder (BD). The present trial was the first to investigate the effect of smartphone-based monitoring on the rate and duration of readmissions in BD. Methods: This was a randomized controlled single-blind parallel-group trial. Patients with BD (ICD-10) discharged from hospitalization in the Mental Health Services, Capital Region of Denmark were randomized 1:1 to daily smartphone-based monitoring including a feedback loop (+ standard treatment) or to standard treatment for 6 months. Primary outcomes: the rate and duration of psychiatric readmissions. Results: We included 98 patients with BD. In ITT analyses, there was no statistically significant difference in rates (hazard rate: 1.05, 95% CI: 0.54; 1.91, p = 0.88) or duration of readmission between the two groups (B: 3.67, 95% CI: −4.77; 12.11, p = 0.39). There was no difference in scores on the Hamilton Depression Rating Scale (B = −0.11, 95% CI: −2.50; 2.29, p = 0.93). The intervention group had higher scores on the Young Mania Rating Scale (B: 1.89, 95% CI: 0.0078; 3.78, p = 0.050). The intervention group reported lower levels of perceived stress (B: -7.18, 95% CI: −13.50; −0.86, p = 0.026) and lower levels of rumination (B: −6.09, 95% CI: −11.19; −1.00, p = 0.019). Conclusions: Smartphone-based monitoring did not reduce rate and duration of readmissions. There was no difference in levels of depressive symptoms. The intervention group had higher levels of manic symptoms, but lower perceived stress and rumination compared with the control group.

AB - Objectives: The MONARCA I and II trials were negative but suggested that smartphone-based monitoring may increase quality of life and reduce perceived stress in bipolar disorder (BD). The present trial was the first to investigate the effect of smartphone-based monitoring on the rate and duration of readmissions in BD. Methods: This was a randomized controlled single-blind parallel-group trial. Patients with BD (ICD-10) discharged from hospitalization in the Mental Health Services, Capital Region of Denmark were randomized 1:1 to daily smartphone-based monitoring including a feedback loop (+ standard treatment) or to standard treatment for 6 months. Primary outcomes: the rate and duration of psychiatric readmissions. Results: We included 98 patients with BD. In ITT analyses, there was no statistically significant difference in rates (hazard rate: 1.05, 95% CI: 0.54; 1.91, p = 0.88) or duration of readmission between the two groups (B: 3.67, 95% CI: −4.77; 12.11, p = 0.39). There was no difference in scores on the Hamilton Depression Rating Scale (B = −0.11, 95% CI: −2.50; 2.29, p = 0.93). The intervention group had higher scores on the Young Mania Rating Scale (B: 1.89, 95% CI: 0.0078; 3.78, p = 0.050). The intervention group reported lower levels of perceived stress (B: -7.18, 95% CI: −13.50; −0.86, p = 0.026) and lower levels of rumination (B: −6.09, 95% CI: −11.19; −1.00, p = 0.019). Conclusions: Smartphone-based monitoring did not reduce rate and duration of readmissions. There was no difference in levels of depressive symptoms. The intervention group had higher levels of manic symptoms, but lower perceived stress and rumination compared with the control group.

KW - bipolar disorder

KW - RADMIS

KW - randomized controlled trial

KW - readmission

KW - smartphone

KW - the Monsenso system

U2 - 10.1111/acps.13274

DO - 10.1111/acps.13274

M3 - Journal article

C2 - 33354769

AN - SCOPUS:85099869588

VL - 143

SP - 453

EP - 465

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 5

ER -

ID: 256719414