Riboswitch-Mediated Gene Regulation: Novel RNA Architectures Dictate Gene Expression Responses

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Riboswitch-Mediated Gene Regulation : Novel RNA Architectures Dictate Gene Expression Responses. / Sherwood, Anna; Henkin, Tina.

In: Annual Review of Microbiology, Vol. 70, 2016, p. 361-376.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Sherwood, A & Henkin, T 2016, 'Riboswitch-Mediated Gene Regulation: Novel RNA Architectures Dictate Gene Expression Responses', Annual Review of Microbiology, vol. 70, pp. 361-376. https://doi.org/10.1146/annurev-micro-091014-104306

APA

Sherwood, A., & Henkin, T. (2016). Riboswitch-Mediated Gene Regulation: Novel RNA Architectures Dictate Gene Expression Responses. Annual Review of Microbiology, 70, 361-376. https://doi.org/10.1146/annurev-micro-091014-104306

Vancouver

Sherwood A, Henkin T. Riboswitch-Mediated Gene Regulation: Novel RNA Architectures Dictate Gene Expression Responses. Annual Review of Microbiology. 2016;70:361-376. https://doi.org/10.1146/annurev-micro-091014-104306

Author

Sherwood, Anna ; Henkin, Tina. / Riboswitch-Mediated Gene Regulation : Novel RNA Architectures Dictate Gene Expression Responses. In: Annual Review of Microbiology. 2016 ; Vol. 70. pp. 361-376.

Bibtex

@article{3c94617b8c284273896b7eaba2dca6ec,
title = "Riboswitch-Mediated Gene Regulation: Novel RNA Architectures Dictate Gene Expression Responses",
abstract = "Riboswitches are RNA elements that act on the mRNA with which they are cotranscribed to modulate expression of that mRNA. These elements are widely found in bacteria, where they have a broad impact on gene expression. The defining feature of riboswitches is that they directly recognize a physiological signal, and the resulting shift in RNA structure affects gene regulation. The majority of riboswitches respond to cellular metabolites, often in a feedback loop to repress synthesis of the enzymes used to produce the metabolite. Related elements respond to the aminoacylation status of a specific tRNA or to a physical parameter, such as temperature or pH. Recent studies have identified new classes of riboswitches and have revealed new insights into the molecular mechanisms of signal recognition and gene regulation. Application of structural and biophysical approaches has complemented previous genetic and biochemical studies, yielding new information about how different riboswitches operate.",
author = "Anna Sherwood and Tina Henkin",
year = "2016",
doi = "10.1146/annurev-micro-091014-104306",
language = "English",
volume = "70",
pages = "361--376",
journal = "Annual Review of Microbiology",
issn = "0066-4227",
publisher = "Annual Reviews, inc.",

}

RIS

TY - JOUR

T1 - Riboswitch-Mediated Gene Regulation

T2 - Novel RNA Architectures Dictate Gene Expression Responses

AU - Sherwood, Anna

AU - Henkin, Tina

PY - 2016

Y1 - 2016

N2 - Riboswitches are RNA elements that act on the mRNA with which they are cotranscribed to modulate expression of that mRNA. These elements are widely found in bacteria, where they have a broad impact on gene expression. The defining feature of riboswitches is that they directly recognize a physiological signal, and the resulting shift in RNA structure affects gene regulation. The majority of riboswitches respond to cellular metabolites, often in a feedback loop to repress synthesis of the enzymes used to produce the metabolite. Related elements respond to the aminoacylation status of a specific tRNA or to a physical parameter, such as temperature or pH. Recent studies have identified new classes of riboswitches and have revealed new insights into the molecular mechanisms of signal recognition and gene regulation. Application of structural and biophysical approaches has complemented previous genetic and biochemical studies, yielding new information about how different riboswitches operate.

AB - Riboswitches are RNA elements that act on the mRNA with which they are cotranscribed to modulate expression of that mRNA. These elements are widely found in bacteria, where they have a broad impact on gene expression. The defining feature of riboswitches is that they directly recognize a physiological signal, and the resulting shift in RNA structure affects gene regulation. The majority of riboswitches respond to cellular metabolites, often in a feedback loop to repress synthesis of the enzymes used to produce the metabolite. Related elements respond to the aminoacylation status of a specific tRNA or to a physical parameter, such as temperature or pH. Recent studies have identified new classes of riboswitches and have revealed new insights into the molecular mechanisms of signal recognition and gene regulation. Application of structural and biophysical approaches has complemented previous genetic and biochemical studies, yielding new information about how different riboswitches operate.

U2 - 10.1146/annurev-micro-091014-104306

DO - 10.1146/annurev-micro-091014-104306

M3 - Review

VL - 70

SP - 361

EP - 376

JO - Annual Review of Microbiology

JF - Annual Review of Microbiology

SN - 0066-4227

ER -

ID: 368624403