Standard
Richness of human gut microbiome correlates with metabolic markers. / Le Chatelier, Emmanuelle; Nielsen, Trine; Qin, Junjie; Prifti, Edi; Hildebrand, Falk; Falony, Gwen; Almeida, Mathieu; Arumugam, Manimozhiyan; Batto, Jean-Michel; Kennedy, Sean; Leonard, Pierre; Li, Junhua; Burgdorf, Kristoffer Sølvsten; Grarup, Niels; Jørgensen, Torben; Brandslund, Ivan; Nielsen, Henrik Bjørn; Juncker, Agnieszka; dos Santos, Marcelo Bertalan Quintanilha; Levenez, Florence; Pons, Nicolas; Rasmussen, Simon; Sunagawa, Shinichi; Tap, Julien; Tims, Sebastian; Zoetendal, Erwin G; Brunak, Søren; Clément, Karine; Doré, Joël; Kleerebezem, Michiel; Kristiansen, Karsten; Renault, Pierre; Sicheritz-Ponten, Thomas; de Vos, Willem M; Zucker, Jean-Daniel; Raes, Jeroen; Hansen, Torben; Bork, Peer; Wang, Jun; Ehrlich, S Dusko; Pedersen, Oluf Borbye; Guedon, Eric; Delorme, Christine; Layec, Séverine; Khaci, Ghalia; van de Guchte, Maarten; Vandemeulebrouck, Gaetana; Jamet, Alexandre; Dervyn, Rozenn; Sanchez, Nicolas; Maguin, Emmanuelle; Haimet, Florence; Winogradski, Yohanan; Cultrone, Antonella; Leclerc, Marion; Juste, Catherine; Blottière, Hervé; Pelletier, Eric; LePaslier, Denis; Artiguenave, François; Bruls, Thomas; Weissenbach, Jean; Turner, Keith; Parkhill, Julian; Antolin, Maria; Manichanh, Chaysavanh; Casellas, Francesc; Boruel, Natalia; Varela, Encarna; Torrejon, Antonio; Guarner, Francisco; Denariaz, Gérard; Derrien, Muriel; van Hylckama Vlieg, Johan E T; Veiga, Patrick; Oozeer, Raish; Knol, Jan; Rescigno, Maria; Brechot, Christian; Mérieux, Alexandre; M'Rini, Christine; Yamada, Takuji.
In:
Nature, Vol. 500, No. 7464, 2013, p. 541-546.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Le Chatelier, E, Nielsen, T, Qin, J, Prifti, E, Hildebrand, F, Falony, G, Almeida, M
, Arumugam, M, Batto, J-M, Kennedy, S, Leonard, P, Li, J
, Burgdorf, KS, Grarup, N, Jørgensen, T, Brandslund, I, Nielsen, HB, Juncker, A, dos Santos, MBQ, Levenez, F, Pons, N
, Rasmussen, S, Sunagawa, S, Tap, J, Tims, S, Zoetendal, EG, Brunak, S, Clément, K, Doré, J, Kleerebezem, M
, Kristiansen, K, Renault, P, Sicheritz-Ponten, T, de Vos, WM, Zucker, J-D, Raes, J
, Hansen, T, Bork, P, Wang, J, Ehrlich, SD
, Pedersen, OB, Guedon, E, Delorme, C, Layec, S, Khaci, G, van de Guchte, M, Vandemeulebrouck, G, Jamet, A, Dervyn, R, Sanchez, N, Maguin, E, Haimet, F, Winogradski, Y, Cultrone, A, Leclerc, M, Juste, C, Blottière, H, Pelletier, E, LePaslier, D, Artiguenave, F, Bruls, T, Weissenbach, J, Turner, K, Parkhill, J, Antolin, M, Manichanh, C, Casellas, F, Boruel, N, Varela, E, Torrejon, A, Guarner, F, Denariaz, G, Derrien, M, van Hylckama Vlieg, JET, Veiga, P, Oozeer, R, Knol, J, Rescigno, M, Brechot, C, Mérieux, A, M'Rini, C & Yamada, T 2013, '
Richness of human gut microbiome correlates with metabolic markers',
Nature, vol. 500, no. 7464, pp. 541-546.
https://doi.org/10.1038/nature12506APA
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M.
, Arumugam, M., Batto, J-M., Kennedy, S., Leonard, P., Li, J.
, Burgdorf, K. S., Grarup, N., Jørgensen, T., Brandslund, I., Nielsen, H. B., Juncker, A., dos Santos, M. B. Q., ... Yamada, T. (2013).
Richness of human gut microbiome correlates with metabolic markers.
Nature,
500(7464), 541-546.
https://doi.org/10.1038/nature12506Vancouver
Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G et al.
Richness of human gut microbiome correlates with metabolic markers.
Nature. 2013;500(7464):541-546.
https://doi.org/10.1038/nature12506Author
Le Chatelier, Emmanuelle ; Nielsen, Trine ; Qin, Junjie ; Prifti, Edi ; Hildebrand, Falk ; Falony, Gwen ; Almeida, Mathieu ; Arumugam, Manimozhiyan ; Batto, Jean-Michel ; Kennedy, Sean ; Leonard, Pierre ; Li, Junhua ; Burgdorf, Kristoffer Sølvsten ; Grarup, Niels ; Jørgensen, Torben ; Brandslund, Ivan ; Nielsen, Henrik Bjørn ; Juncker, Agnieszka ; dos Santos, Marcelo Bertalan Quintanilha ; Levenez, Florence ; Pons, Nicolas ; Rasmussen, Simon ; Sunagawa, Shinichi ; Tap, Julien ; Tims, Sebastian ; Zoetendal, Erwin G ; Brunak, Søren ; Clément, Karine ; Doré, Joël ; Kleerebezem, Michiel ; Kristiansen, Karsten ; Renault, Pierre ; Sicheritz-Ponten, Thomas ; de Vos, Willem M ; Zucker, Jean-Daniel ; Raes, Jeroen ; Hansen, Torben ; Bork, Peer ; Wang, Jun ; Ehrlich, S Dusko ; Pedersen, Oluf Borbye ; Guedon, Eric ; Delorme, Christine ; Layec, Séverine ; Khaci, Ghalia ; van de Guchte, Maarten ; Vandemeulebrouck, Gaetana ; Jamet, Alexandre ; Dervyn, Rozenn ; Sanchez, Nicolas ; Maguin, Emmanuelle ; Haimet, Florence ; Winogradski, Yohanan ; Cultrone, Antonella ; Leclerc, Marion ; Juste, Catherine ; Blottière, Hervé ; Pelletier, Eric ; LePaslier, Denis ; Artiguenave, François ; Bruls, Thomas ; Weissenbach, Jean ; Turner, Keith ; Parkhill, Julian ; Antolin, Maria ; Manichanh, Chaysavanh ; Casellas, Francesc ; Boruel, Natalia ; Varela, Encarna ; Torrejon, Antonio ; Guarner, Francisco ; Denariaz, Gérard ; Derrien, Muriel ; van Hylckama Vlieg, Johan E T ; Veiga, Patrick ; Oozeer, Raish ; Knol, Jan ; Rescigno, Maria ; Brechot, Christian ; Mérieux, Alexandre ; M'Rini, Christine ; Yamada, Takuji. / Richness of human gut microbiome correlates with metabolic markers. In: Nature. 2013 ; Vol. 500, No. 7464. pp. 541-546.
Bibtex
@article{3ac22222792e456e9c487251a2710717,
title = "Richness of human gut microbiome correlates with metabolic markers",
abstract = "We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.",
author = "{Le Chatelier}, Emmanuelle and Trine Nielsen and Junjie Qin and Edi Prifti and Falk Hildebrand and Gwen Falony and Mathieu Almeida and Manimozhiyan Arumugam and Jean-Michel Batto and Sean Kennedy and Pierre Leonard and Junhua Li and Burgdorf, {Kristoffer S{\o}lvsten} and Niels Grarup and Torben J{\o}rgensen and Ivan Brandslund and Nielsen, {Henrik Bj{\o}rn} and Agnieszka Juncker and {dos Santos}, {Marcelo Bertalan Quintanilha} and Florence Levenez and Nicolas Pons and Simon Rasmussen and Shinichi Sunagawa and Julien Tap and Sebastian Tims and Zoetendal, {Erwin G} and S{\o}ren Brunak and Karine Cl{\'e}ment and Jo{\"e}l Dor{\'e} and Michiel Kleerebezem and Karsten Kristiansen and Pierre Renault and Thomas Sicheritz-Ponten and {de Vos}, {Willem M} and Jean-Daniel Zucker and Jeroen Raes and Torben Hansen and Peer Bork and Jun Wang and Ehrlich, {S Dusko} and Pedersen, {Oluf Borbye} and Eric Guedon and Christine Delorme and S{\'e}verine Layec and Ghalia Khaci and {van de Guchte}, Maarten and Gaetana Vandemeulebrouck and Alexandre Jamet and Rozenn Dervyn and Nicolas Sanchez and Emmanuelle Maguin and Florence Haimet and Yohanan Winogradski and Antonella Cultrone and Marion Leclerc and Catherine Juste and Herv{\'e} Blotti{\`e}re and Eric Pelletier and Denis LePaslier and Fran{\c c}ois Artiguenave and Thomas Bruls and Jean Weissenbach and Keith Turner and Julian Parkhill and Maria Antolin and Chaysavanh Manichanh and Francesc Casellas and Natalia Boruel and Encarna Varela and Antonio Torrejon and Francisco Guarner and G{\'e}rard Denariaz and Muriel Derrien and {van Hylckama Vlieg}, {Johan E T} and Patrick Veiga and Raish Oozeer and Jan Knol and Maria Rescigno and Christian Brechot and Alexandre M{\'e}rieux and Christine M'Rini and Takuji Yamada",
year = "2013",
doi = "10.1038/nature12506",
language = "English",
volume = "500",
pages = "541--546",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7464",
}
RIS
TY - JOUR
T1 - Richness of human gut microbiome correlates with metabolic markers
AU - Le Chatelier, Emmanuelle
AU - Nielsen, Trine
AU - Qin, Junjie
AU - Prifti, Edi
AU - Hildebrand, Falk
AU - Falony, Gwen
AU - Almeida, Mathieu
AU - Arumugam, Manimozhiyan
AU - Batto, Jean-Michel
AU - Kennedy, Sean
AU - Leonard, Pierre
AU - Li, Junhua
AU - Burgdorf, Kristoffer Sølvsten
AU - Grarup, Niels
AU - Jørgensen, Torben
AU - Brandslund, Ivan
AU - Nielsen, Henrik Bjørn
AU - Juncker, Agnieszka
AU - dos Santos, Marcelo Bertalan Quintanilha
AU - Levenez, Florence
AU - Pons, Nicolas
AU - Rasmussen, Simon
AU - Sunagawa, Shinichi
AU - Tap, Julien
AU - Tims, Sebastian
AU - Zoetendal, Erwin G
AU - Brunak, Søren
AU - Clément, Karine
AU - Doré, Joël
AU - Kleerebezem, Michiel
AU - Kristiansen, Karsten
AU - Renault, Pierre
AU - Sicheritz-Ponten, Thomas
AU - de Vos, Willem M
AU - Zucker, Jean-Daniel
AU - Raes, Jeroen
AU - Hansen, Torben
AU - Bork, Peer
AU - Wang, Jun
AU - Ehrlich, S Dusko
AU - Pedersen, Oluf Borbye
AU - Guedon, Eric
AU - Delorme, Christine
AU - Layec, Séverine
AU - Khaci, Ghalia
AU - van de Guchte, Maarten
AU - Vandemeulebrouck, Gaetana
AU - Jamet, Alexandre
AU - Dervyn, Rozenn
AU - Sanchez, Nicolas
AU - Maguin, Emmanuelle
AU - Haimet, Florence
AU - Winogradski, Yohanan
AU - Cultrone, Antonella
AU - Leclerc, Marion
AU - Juste, Catherine
AU - Blottière, Hervé
AU - Pelletier, Eric
AU - LePaslier, Denis
AU - Artiguenave, François
AU - Bruls, Thomas
AU - Weissenbach, Jean
AU - Turner, Keith
AU - Parkhill, Julian
AU - Antolin, Maria
AU - Manichanh, Chaysavanh
AU - Casellas, Francesc
AU - Boruel, Natalia
AU - Varela, Encarna
AU - Torrejon, Antonio
AU - Guarner, Francisco
AU - Denariaz, Gérard
AU - Derrien, Muriel
AU - van Hylckama Vlieg, Johan E T
AU - Veiga, Patrick
AU - Oozeer, Raish
AU - Knol, Jan
AU - Rescigno, Maria
AU - Brechot, Christian
AU - Mérieux, Alexandre
AU - M'Rini, Christine
AU - Yamada, Takuji
PY - 2013
Y1 - 2013
N2 - We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
AB - We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
U2 - 10.1038/nature12506
DO - 10.1038/nature12506
M3 - Journal article
C2 - 23985870
VL - 500
SP - 541
EP - 546
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7464
ER -
