Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. / Fürstenberger, Gerhard; Epp, Nikolas; Eckl, Katja-Martina; Hennies, Hans Christian; Hallenborg, Philip; Kristiansen, Karsten; Jørgensen, Claus; Krieg, Peter.

In: Prostaglandins & Other Lipid Mediators, Vol. 82, No. 1-4, 2007, p. 128-34.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fürstenberger, G, Epp, N, Eckl, K-M, Hennies, HC, Hallenborg, P, Kristiansen, K, Jørgensen, C & Krieg, P 2007, 'Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation', Prostaglandins & Other Lipid Mediators, vol. 82, no. 1-4, pp. 128-34. https://doi.org/10.1016/j.prostaglandins.2006.05.006

APA

Fürstenberger, G., Epp, N., Eckl, K-M., Hennies, H. C., Hallenborg, P., Kristiansen, K., Jørgensen, C., & Krieg, P. (2007). Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. Prostaglandins & Other Lipid Mediators, 82(1-4), 128-34. https://doi.org/10.1016/j.prostaglandins.2006.05.006

Vancouver

Fürstenberger G, Epp N, Eckl K-M, Hennies HC, Hallenborg P, Kristiansen K et al. Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. Prostaglandins & Other Lipid Mediators. 2007;82(1-4):128-34. https://doi.org/10.1016/j.prostaglandins.2006.05.006

Author

Fürstenberger, Gerhard ; Epp, Nikolas ; Eckl, Katja-Martina ; Hennies, Hans Christian ; Hallenborg, Philip ; Kristiansen, Karsten ; Jørgensen, Claus ; Krieg, Peter. / Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. In: Prostaglandins & Other Lipid Mediators. 2007 ; Vol. 82, No. 1-4. pp. 128-34.

Bibtex

@article{0d55c020f75411ddbf70000ea68e967b,
title = "Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation",
abstract = "12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.",
author = "Gerhard F{\"u}rstenberger and Nikolas Epp and Katja-Martina Eckl and Hennies, {Hans Christian} and Philip Hallenborg and Karsten Kristiansen and Claus J{\o}rgensen and Peter Krieg",
year = "2007",
doi = "10.1016/j.prostaglandins.2006.05.006",
language = "English",
volume = "82",
pages = "128--34",
journal = "Prostaglandins and Other Lipid Mediators",
issn = "1098-8823",
publisher = "Elsevier",
number = "1-4",

}

RIS

TY - JOUR

T1 - Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation

AU - Fürstenberger, Gerhard

AU - Epp, Nikolas

AU - Eckl, Katja-Martina

AU - Hennies, Hans Christian

AU - Hallenborg, Philip

AU - Kristiansen, Karsten

AU - Jørgensen, Claus

AU - Krieg, Peter

PY - 2007

Y1 - 2007

N2 - 12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.

AB - 12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.

U2 - 10.1016/j.prostaglandins.2006.05.006

DO - 10.1016/j.prostaglandins.2006.05.006

M3 - Journal article

C2 - 17164140

VL - 82

SP - 128

EP - 134

JO - Prostaglandins and Other Lipid Mediators

JF - Prostaglandins and Other Lipid Mediators

SN - 1098-8823

IS - 1-4

ER -

ID: 10242633