Sex differences in the oral microbiome, host traits, and their causal relationships

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Sex differences in the oral microbiome, host traits, and their causal relationships. / Liu, Xiaomin; Tong, Xin; Jie, Zhuye; Zhu, Jie; Tian, Liu; Sun, Qiang; Ju, Yanmei; Zou, Leying; Lu, Haorong; Qiu, Xuemei; Li, Qiang; Liao, Yunli; Lian, Heng; Zuo, Yong; Chen, Xiaomin; Rao, Weiqiao; Ren, Yan; Wang, Yuan; Zi, Jin; Wang, Rong; Xu, Xun; Yang, Huanming; Wang, Jian; Zong, Yang; Liu, Weibin; Hou, Yong; Jin, Xin; Xiao, Liang; Kristiansen, Karsten; Jia, Huijue; Zhang, Tao.

In: iScience, Vol. 26, No. 1, 105839, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Liu, X, Tong, X, Jie, Z, Zhu, J, Tian, L, Sun, Q, Ju, Y, Zou, L, Lu, H, Qiu, X, Li, Q, Liao, Y, Lian, H, Zuo, Y, Chen, X, Rao, W, Ren, Y, Wang, Y, Zi, J, Wang, R, Xu, X, Yang, H, Wang, J, Zong, Y, Liu, W, Hou, Y, Jin, X, Xiao, L, Kristiansen, K, Jia, H & Zhang, T 2023, 'Sex differences in the oral microbiome, host traits, and their causal relationships', iScience, vol. 26, no. 1, 105839. https://doi.org/10.1016/j.isci.2022.105839

APA

Liu, X., Tong, X., Jie, Z., Zhu, J., Tian, L., Sun, Q., Ju, Y., Zou, L., Lu, H., Qiu, X., Li, Q., Liao, Y., Lian, H., Zuo, Y., Chen, X., Rao, W., Ren, Y., Wang, Y., Zi, J., ... Zhang, T. (2023). Sex differences in the oral microbiome, host traits, and their causal relationships. iScience, 26(1), [105839]. https://doi.org/10.1016/j.isci.2022.105839

Vancouver

Liu X, Tong X, Jie Z, Zhu J, Tian L, Sun Q et al. Sex differences in the oral microbiome, host traits, and their causal relationships. iScience. 2023;26(1). 105839. https://doi.org/10.1016/j.isci.2022.105839

Author

Liu, Xiaomin ; Tong, Xin ; Jie, Zhuye ; Zhu, Jie ; Tian, Liu ; Sun, Qiang ; Ju, Yanmei ; Zou, Leying ; Lu, Haorong ; Qiu, Xuemei ; Li, Qiang ; Liao, Yunli ; Lian, Heng ; Zuo, Yong ; Chen, Xiaomin ; Rao, Weiqiao ; Ren, Yan ; Wang, Yuan ; Zi, Jin ; Wang, Rong ; Xu, Xun ; Yang, Huanming ; Wang, Jian ; Zong, Yang ; Liu, Weibin ; Hou, Yong ; Jin, Xin ; Xiao, Liang ; Kristiansen, Karsten ; Jia, Huijue ; Zhang, Tao. / Sex differences in the oral microbiome, host traits, and their causal relationships. In: iScience. 2023 ; Vol. 26, No. 1.

Bibtex

@article{72bf8629e2924b6694dd298bbe8fadb0,

title = "Sex differences in the oral microbiome, host traits, and their causal relationships",

abstract = "The oral microbiome has been implicated in a growing number of diseases; however, determinants of the oral microbiome and their roles remain elusive. Here, we investigated the oral (saliva and tongue dorsum) metagenome, the whole genome, and other omics data in a total of 4,478 individuals and demonstrated that the oral microbiome composition and its major contributing host factors significantly differed between sexes. We thus conducted a sex-stratified metagenome-genome-wide-association study (M-GWAS) and identified 11 differential genetic associations with the oral microbiome (psex-difference < 5 × 10−8). Furthermore, we performed sex-stratified Mendelian randomization (MR) analyses and identified abundant causalities between the oral microbiome and serum metabolites. Notably, sex-specific microbes-hormonal interactions explained the mostly observed sex hormones differences such as the significant causalities enrichments for aldosterone in females and androstenedione in males. These findings illustrate the necessity of sex stratification and deepen our understanding of the interplay between the oral microbiome and serum metabolites.",

keywords = "Microbial metabolism, Microbiome, Oral microbiology",

author = "Xiaomin Liu and Xin Tong and Zhuye Jie and Jie Zhu and Liu Tian and Qiang Sun and Yanmei Ju and Leying Zou and Haorong Lu and Xuemei Qiu and Qiang Li and Yunli Liao and Heng Lian and Yong Zuo and Xiaomin Chen and Weiqiao Rao and Yan Ren and Yuan Wang and Jin Zi and Rong Wang and Xun Xu and Huanming Yang and Jian Wang and Yang Zong and Weibin Liu and Yong Hou and Xin Jin and Liang Xiao and Karsten Kristiansen and Huijue Jia and Tao Zhang",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2023",

doi = "10.1016/j.isci.2022.105839",

language = "English",

volume = "26",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Sex differences in the oral microbiome, host traits, and their causal relationships

AU - Liu, Xiaomin

AU - Tong, Xin

AU - Jie, Zhuye

AU - Zhu, Jie

AU - Tian, Liu

AU - Sun, Qiang

AU - Ju, Yanmei

AU - Zou, Leying

AU - Lu, Haorong

AU - Qiu, Xuemei

AU - Li, Qiang

AU - Liao, Yunli

AU - Lian, Heng

AU - Zuo, Yong

AU - Chen, Xiaomin

AU - Rao, Weiqiao

AU - Ren, Yan

AU - Wang, Yuan

AU - Zi, Jin

AU - Wang, Rong

AU - Xu, Xun

AU - Yang, Huanming

AU - Wang, Jian

AU - Zong, Yang

AU - Liu, Weibin

AU - Hou, Yong

AU - Jin, Xin

AU - Xiao, Liang

AU - Kristiansen, Karsten

AU - Jia, Huijue

AU - Zhang, Tao

PY - 2023

Y1 - 2023

N2 - The oral microbiome has been implicated in a growing number of diseases; however, determinants of the oral microbiome and their roles remain elusive. Here, we investigated the oral (saliva and tongue dorsum) metagenome, the whole genome, and other omics data in a total of 4,478 individuals and demonstrated that the oral microbiome composition and its major contributing host factors significantly differed between sexes. We thus conducted a sex-stratified metagenome-genome-wide-association study (M-GWAS) and identified 11 differential genetic associations with the oral microbiome (psex-difference < 5 × 10−8). Furthermore, we performed sex-stratified Mendelian randomization (MR) analyses and identified abundant causalities between the oral microbiome and serum metabolites. Notably, sex-specific microbes-hormonal interactions explained the mostly observed sex hormones differences such as the significant causalities enrichments for aldosterone in females and androstenedione in males. These findings illustrate the necessity of sex stratification and deepen our understanding of the interplay between the oral microbiome and serum metabolites.

AB - The oral microbiome has been implicated in a growing number of diseases; however, determinants of the oral microbiome and their roles remain elusive. Here, we investigated the oral (saliva and tongue dorsum) metagenome, the whole genome, and other omics data in a total of 4,478 individuals and demonstrated that the oral microbiome composition and its major contributing host factors significantly differed between sexes. We thus conducted a sex-stratified metagenome-genome-wide-association study (M-GWAS) and identified 11 differential genetic associations with the oral microbiome (psex-difference < 5 × 10−8). Furthermore, we performed sex-stratified Mendelian randomization (MR) analyses and identified abundant causalities between the oral microbiome and serum metabolites. Notably, sex-specific microbes-hormonal interactions explained the mostly observed sex hormones differences such as the significant causalities enrichments for aldosterone in females and androstenedione in males. These findings illustrate the necessity of sex stratification and deepen our understanding of the interplay between the oral microbiome and serum metabolites.

KW - Microbial metabolism

KW - Microbiome

KW - Oral microbiology

U2 - 10.1016/j.isci.2022.105839

DO - 10.1016/j.isci.2022.105839

M3 - Journal article

C2 - 36660475

AN - SCOPUS:85146072275

VL - 26

JO - iScience

JF - iScience

SN - 2589-0042

IS - 1

M1 - 105839

ER -

ID: 334257592

Department of Biology