Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome. / Xie, Hailiang; Guo, Ruijin; Zhong, Huanzi; Feng, Qiang; Lan, Zhou; Qin, Bingcai; Ward, Kirsten J.; Jackson, Matthew A.; Xia, Yan; Chen, Xu; Chen, Bing; Xia, Huihua; Xu, Changlu; Li, Fei; Xu, Xun; Al-Aama, Jumana Yousuf; Yang, Huanming; Wang, Jian; Kristiansen, Karsten; Wang, Jun; Steves, Claire J.; Bell, Jordana T.; Li, Junhua; Spector, Timothy D.; Jia, Huijue.

In: Cell Systems, Vol. 3, No. 6, 2016, p. 572-584.e3.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Xie, H, Guo, R, Zhong, H, Feng, Q, Lan, Z, Qin, B, Ward, KJ, Jackson, MA, Xia, Y, Chen, X, Chen, B, Xia, H, Xu, C, Li, F, Xu, X, Al-Aama, JY, Yang, H, Wang, J, Kristiansen, K, Wang, J, Steves, CJ, Bell, JT, Li, J, Spector, TD & Jia, H 2016, 'Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome', Cell Systems, vol. 3, no. 6, pp. 572-584.e3. https://doi.org/10.1016/j.cels.2016.10.004

APA

Xie, H., Guo, R., Zhong, H., Feng, Q., Lan, Z., Qin, B., Ward, K. J., Jackson, M. A., Xia, Y., Chen, X., Chen, B., Xia, H., Xu, C., Li, F., Xu, X., Al-Aama, J. Y., Yang, H., Wang, J., Kristiansen, K., ... Jia, H. (2016). Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome. Cell Systems, 3(6), 572-584.e3. https://doi.org/10.1016/j.cels.2016.10.004

Vancouver

Xie H, Guo R, Zhong H, Feng Q, Lan Z, Qin B et al. Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome. Cell Systems. 2016;3(6):572-584.e3. https://doi.org/10.1016/j.cels.2016.10.004

Author

Xie, Hailiang ; Guo, Ruijin ; Zhong, Huanzi ; Feng, Qiang ; Lan, Zhou ; Qin, Bingcai ; Ward, Kirsten J. ; Jackson, Matthew A. ; Xia, Yan ; Chen, Xu ; Chen, Bing ; Xia, Huihua ; Xu, Changlu ; Li, Fei ; Xu, Xun ; Al-Aama, Jumana Yousuf ; Yang, Huanming ; Wang, Jian ; Kristiansen, Karsten ; Wang, Jun ; Steves, Claire J. ; Bell, Jordana T. ; Li, Junhua ; Spector, Timothy D. ; Jia, Huijue. / Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome. In: Cell Systems. 2016 ; Vol. 3, No. 6. pp. 572-584.e3.

Bibtex

@article{5ef30bbbf3a549bd81d113075bd39c49,
title = "Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome",
abstract = "The gut microbiota has been typically viewed as an environmental factor for human health. Twins are well suited for investigating the concordance of their gut microbiomes and decomposing genetic and environmental influences. However, existing twin studies utilizing metagenomic shotgun sequencing have included only a few samples. Here, we sequenced fecal samples from 250 adult twins in the TwinsUK registry and constructed a comprehensive gut microbial reference gene catalog. We demonstrate heritability of many microbial taxa and functional modules in the gut microbiome, including those associated with diseases. Moreover, we identified 8 million SNPs in the gut microbiome and observe a high similarity in microbiome SNPs between twins that slowly decreases after decades of living apart. The results shed new light on the genetic and environmental influences on the composition and function of the gut microbiome that could relate to risk of complex diseases.",
keywords = "heritability, metabolic diseases, microbiome, SNPs",
author = "Hailiang Xie and Ruijin Guo and Huanzi Zhong and Qiang Feng and Zhou Lan and Bingcai Qin and Ward, {Kirsten J.} and Jackson, {Matthew A.} and Yan Xia and Xu Chen and Bing Chen and Huihua Xia and Changlu Xu and Fei Li and Xun Xu and Al-Aama, {Jumana Yousuf} and Huanming Yang and Jian Wang and Karsten Kristiansen and Jun Wang and Steves, {Claire J.} and Bell, {Jordana T.} and Junhua Li and Spector, {Timothy D.} and Huijue Jia",
year = "2016",
doi = "10.1016/j.cels.2016.10.004",
language = "English",
volume = "3",
pages = "572--584.e3",
journal = "Cell Systems",
issn = "2405-4712",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome

AU - Xie, Hailiang

AU - Guo, Ruijin

AU - Zhong, Huanzi

AU - Feng, Qiang

AU - Lan, Zhou

AU - Qin, Bingcai

AU - Ward, Kirsten J.

AU - Jackson, Matthew A.

AU - Xia, Yan

AU - Chen, Xu

AU - Chen, Bing

AU - Xia, Huihua

AU - Xu, Changlu

AU - Li, Fei

AU - Xu, Xun

AU - Al-Aama, Jumana Yousuf

AU - Yang, Huanming

AU - Wang, Jian

AU - Kristiansen, Karsten

AU - Wang, Jun

AU - Steves, Claire J.

AU - Bell, Jordana T.

AU - Li, Junhua

AU - Spector, Timothy D.

AU - Jia, Huijue

PY - 2016

Y1 - 2016

N2 - The gut microbiota has been typically viewed as an environmental factor for human health. Twins are well suited for investigating the concordance of their gut microbiomes and decomposing genetic and environmental influences. However, existing twin studies utilizing metagenomic shotgun sequencing have included only a few samples. Here, we sequenced fecal samples from 250 adult twins in the TwinsUK registry and constructed a comprehensive gut microbial reference gene catalog. We demonstrate heritability of many microbial taxa and functional modules in the gut microbiome, including those associated with diseases. Moreover, we identified 8 million SNPs in the gut microbiome and observe a high similarity in microbiome SNPs between twins that slowly decreases after decades of living apart. The results shed new light on the genetic and environmental influences on the composition and function of the gut microbiome that could relate to risk of complex diseases.

AB - The gut microbiota has been typically viewed as an environmental factor for human health. Twins are well suited for investigating the concordance of their gut microbiomes and decomposing genetic and environmental influences. However, existing twin studies utilizing metagenomic shotgun sequencing have included only a few samples. Here, we sequenced fecal samples from 250 adult twins in the TwinsUK registry and constructed a comprehensive gut microbial reference gene catalog. We demonstrate heritability of many microbial taxa and functional modules in the gut microbiome, including those associated with diseases. Moreover, we identified 8 million SNPs in the gut microbiome and observe a high similarity in microbiome SNPs between twins that slowly decreases after decades of living apart. The results shed new light on the genetic and environmental influences on the composition and function of the gut microbiome that could relate to risk of complex diseases.

KW - heritability

KW - metabolic diseases

KW - microbiome

KW - SNPs

U2 - 10.1016/j.cels.2016.10.004

DO - 10.1016/j.cels.2016.10.004

M3 - Journal article

C2 - 27818083

AN - SCOPUS:85006105634

VL - 3

SP - 572-584.e3

JO - Cell Systems

JF - Cell Systems

SN - 2405-4712

IS - 6

ER -

ID: 171653678