Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes
Research output: Contribution to journal › Journal article › Research › peer-review
The 825C>T polymorphism in the gene encoding the G protein beta3 subunit (GNB3) causes enhanced G protein activation and increased in vitro cell proliferation. This polymorphism is also repeatedly associated with an increased risk of hypertension and has been studied in relation to obesity with divergent results. Only a few association studies have investigated whether this polymorphism is related to type 2 diabetes or the metabolic syndrome. We estimated the impact of the GNB3 825C>T polymorphism in relatively large-scale association studies of common phenotypes of the metabolic syndrome.
| Original language | English |
|---|---|
| Journal | Diabetologia |
| Volume | 49 |
| Issue number | 1 |
| Pages (from-to) | 75-82 |
| Number of pages | 8 |
| ISSN | 0012-186X |
| DOIs | |
| Publication status | Published - 2006 |
| Externally published | Yes |
- Adult, Blood Glucose, Denmark, European Continental Ancestry Group, Fasting, Female, Genotype, Glucose Tolerance Test, Heterotrimeric GTP-Binding Proteins, Humans, Hypertension, Male, Metabolic Syndrome X, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors
Research areas
ID: 45578331