The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity

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Standard

The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity. / Rydén, Mikael; Hrydziuszko, Olga; Mileti, Enrichetta; Raman, Amitha; Lange, Jette Bornholdt; Boyd, Mette; Toft, Eva; Qvist, Veronica; Näslund, Erik; Thorell, Anders; Andersson, Daniel P.; Dahlman, Ingrid; Gao, Hui; Sandelin, Albin Gustav; Daub, Carsten O.; Arner, Peter.

In: Cell Reports, Vol. 16, No. 9, 2016, p. 2317-2326.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rydén, M, Hrydziuszko, O, Mileti, E, Raman, A, Lange, JB, Boyd, M, Toft, E, Qvist, V, Näslund, E, Thorell, A, Andersson, DP, Dahlman, I, Gao, H, Sandelin, AG, Daub, CO & Arner, P 2016, 'The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity', Cell Reports, vol. 16, no. 9, pp. 2317-2326. https://doi.org/10.1016/j.celrep.2016.07.070

APA

Rydén, M., Hrydziuszko, O., Mileti, E., Raman, A., Lange, J. B., Boyd, M., Toft, E., Qvist, V., Näslund, E., Thorell, A., Andersson, D. P., Dahlman, I., Gao, H., Sandelin, A. G., Daub, C. O., & Arner, P. (2016). The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity. Cell Reports, 16(9), 2317-2326. https://doi.org/10.1016/j.celrep.2016.07.070

Vancouver

Rydén M, Hrydziuszko O, Mileti E, Raman A, Lange JB, Boyd M et al. The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity. Cell Reports. 2016;16(9):2317-2326. https://doi.org/10.1016/j.celrep.2016.07.070

Author

Rydén, Mikael ; Hrydziuszko, Olga ; Mileti, Enrichetta ; Raman, Amitha ; Lange, Jette Bornholdt ; Boyd, Mette ; Toft, Eva ; Qvist, Veronica ; Näslund, Erik ; Thorell, Anders ; Andersson, Daniel P. ; Dahlman, Ingrid ; Gao, Hui ; Sandelin, Albin Gustav ; Daub, Carsten O. ; Arner, Peter. / The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity. In: Cell Reports. 2016 ; Vol. 16, No. 9. pp. 2317-2326.

Bibtex

@article{e741a15640d94a4dba357cebbb22ecf1,
title = "The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity",
abstract = "Metabolically healthy obese subjects display preserved insulin sensitivity and a beneficial white adipose tissue gene expression pattern. However, this observation stems from fasting studies when insulin levels are low. We investigated adipose gene expression by 5'Cap-mRNA sequencing in 17 healthy non-obese (NO), 21 insulin-sensitive severely obese (ISO), and 30 insulin-resistant severely obese (IRO) subjects, before and 2 hr into a hyperinsulinemic euglycemic clamp. ISO and IRO subjects displayed a clear but globally similar transcriptional response to insulin, which differed from the small effects observed in NO subjects. In the obese, 231 genes were altered; 71 were enriched in ISO subjects (e.g., phosphorylation processes), and 52 were enriched in IRO subjects (e.g., cellular stimuli). Common cardio-metabolic risk factors and gender do not influence these findings. This study demonstrates that differences in the acute transcriptional response to insulin are primarily driven by obesity per se, challenging the notion of healthy obese adipose tissue, at least in severe obesity.",
keywords = "Journal Article",
author = "Mikael Ryd{\'e}n and Olga Hrydziuszko and Enrichetta Mileti and Amitha Raman and Lange, {Jette Bornholdt} and Mette Boyd and Eva Toft and Veronica Qvist and Erik N{\"a}slund and Anders Thorell and Andersson, {Daniel P.} and Ingrid Dahlman and Hui Gao and Sandelin, {Albin Gustav} and Daub, {Carsten O.} and Peter Arner",
note = "Copyright {\textcopyright} 2016 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2016",
doi = "10.1016/j.celrep.2016.07.070",
language = "English",
volume = "16",
pages = "2317--2326",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "9",

}

RIS

TY - JOUR

T1 - The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity

AU - Rydén, Mikael

AU - Hrydziuszko, Olga

AU - Mileti, Enrichetta

AU - Raman, Amitha

AU - Lange, Jette Bornholdt

AU - Boyd, Mette

AU - Toft, Eva

AU - Qvist, Veronica

AU - Näslund, Erik

AU - Thorell, Anders

AU - Andersson, Daniel P.

AU - Dahlman, Ingrid

AU - Gao, Hui

AU - Sandelin, Albin Gustav

AU - Daub, Carsten O.

AU - Arner, Peter

N1 - Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2016

Y1 - 2016

N2 - Metabolically healthy obese subjects display preserved insulin sensitivity and a beneficial white adipose tissue gene expression pattern. However, this observation stems from fasting studies when insulin levels are low. We investigated adipose gene expression by 5'Cap-mRNA sequencing in 17 healthy non-obese (NO), 21 insulin-sensitive severely obese (ISO), and 30 insulin-resistant severely obese (IRO) subjects, before and 2 hr into a hyperinsulinemic euglycemic clamp. ISO and IRO subjects displayed a clear but globally similar transcriptional response to insulin, which differed from the small effects observed in NO subjects. In the obese, 231 genes were altered; 71 were enriched in ISO subjects (e.g., phosphorylation processes), and 52 were enriched in IRO subjects (e.g., cellular stimuli). Common cardio-metabolic risk factors and gender do not influence these findings. This study demonstrates that differences in the acute transcriptional response to insulin are primarily driven by obesity per se, challenging the notion of healthy obese adipose tissue, at least in severe obesity.

AB - Metabolically healthy obese subjects display preserved insulin sensitivity and a beneficial white adipose tissue gene expression pattern. However, this observation stems from fasting studies when insulin levels are low. We investigated adipose gene expression by 5'Cap-mRNA sequencing in 17 healthy non-obese (NO), 21 insulin-sensitive severely obese (ISO), and 30 insulin-resistant severely obese (IRO) subjects, before and 2 hr into a hyperinsulinemic euglycemic clamp. ISO and IRO subjects displayed a clear but globally similar transcriptional response to insulin, which differed from the small effects observed in NO subjects. In the obese, 231 genes were altered; 71 were enriched in ISO subjects (e.g., phosphorylation processes), and 52 were enriched in IRO subjects (e.g., cellular stimuli). Common cardio-metabolic risk factors and gender do not influence these findings. This study demonstrates that differences in the acute transcriptional response to insulin are primarily driven by obesity per se, challenging the notion of healthy obese adipose tissue, at least in severe obesity.

KW - Journal Article

U2 - 10.1016/j.celrep.2016.07.070

DO - 10.1016/j.celrep.2016.07.070

M3 - Journal article

C2 - 27545890

VL - 16

SP - 2317

EP - 2326

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 9

ER -

ID: 165390094