The effect of smartphone-based monitoring and treatment on the rate and duration of psychiatric readmission in patients with unipolar depressive disorder: The RADMIS randomized controlled trial

Research output: Contribution to journalJournal articlepeer-review

Standard

The effect of smartphone-based monitoring and treatment on the rate and duration of psychiatric readmission in patients with unipolar depressive disorder : The RADMIS randomized controlled trial. / Tønning, Morten Lindbjerg; Faurholt-Jepsen, Maria; Frost, Mads; Martiny, Klaus; Tuxen, Nanna; Rosenberg, Nicole; Busk, Jonas; Winther, Ole; Melbye, Sigurd Arne; Thaysen-Petersen, Daniel; Aamund, Kate Andreasson; Tolderlundh, Lizzie; Bardram, Jakob Eyvind; Kessing, Lars Vedel.

In: Journal of Affective Disorders, Vol. 282, 2021, p. 354-363.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Tønning, ML, Faurholt-Jepsen, M, Frost, M, Martiny, K, Tuxen, N, Rosenberg, N, Busk, J, Winther, O, Melbye, SA, Thaysen-Petersen, D, Aamund, KA, Tolderlundh, L, Bardram, JE & Kessing, LV 2021, 'The effect of smartphone-based monitoring and treatment on the rate and duration of psychiatric readmission in patients with unipolar depressive disorder: The RADMIS randomized controlled trial', Journal of Affective Disorders, vol. 282, pp. 354-363. https://doi.org/10.1016/j.jad.2020.12.141

APA

Tønning, M. L., Faurholt-Jepsen, M., Frost, M., Martiny, K., Tuxen, N., Rosenberg, N., Busk, J., Winther, O., Melbye, S. A., Thaysen-Petersen, D., Aamund, K. A., Tolderlundh, L., Bardram, J. E., & Kessing, L. V. (2021). The effect of smartphone-based monitoring and treatment on the rate and duration of psychiatric readmission in patients with unipolar depressive disorder: The RADMIS randomized controlled trial. Journal of Affective Disorders, 282, 354-363. https://doi.org/10.1016/j.jad.2020.12.141

Vancouver

Tønning ML, Faurholt-Jepsen M, Frost M, Martiny K, Tuxen N, Rosenberg N et al. The effect of smartphone-based monitoring and treatment on the rate and duration of psychiatric readmission in patients with unipolar depressive disorder: The RADMIS randomized controlled trial. Journal of Affective Disorders. 2021;282:354-363. https://doi.org/10.1016/j.jad.2020.12.141

Author

Tønning, Morten Lindbjerg ; Faurholt-Jepsen, Maria ; Frost, Mads ; Martiny, Klaus ; Tuxen, Nanna ; Rosenberg, Nicole ; Busk, Jonas ; Winther, Ole ; Melbye, Sigurd Arne ; Thaysen-Petersen, Daniel ; Aamund, Kate Andreasson ; Tolderlundh, Lizzie ; Bardram, Jakob Eyvind ; Kessing, Lars Vedel. / The effect of smartphone-based monitoring and treatment on the rate and duration of psychiatric readmission in patients with unipolar depressive disorder : The RADMIS randomized controlled trial. In: Journal of Affective Disorders. 2021 ; Vol. 282. pp. 354-363.

Bibtex

@article{0abd03bedf8a4cd8b97656e1875072eb,
title = "The effect of smartphone-based monitoring and treatment on the rate and duration of psychiatric readmission in patients with unipolar depressive disorder: The RADMIS randomized controlled trial",
abstract = "Background: Patients with unipolar depressive disorder are frequently hospitalized, and the period following discharge is a high-risk-period. Smartphone-based treatments are receiving increasing attention among researchers, clinicians, and patients. We aimed to investigate whether a smartphone-based monitoring and treatment system reduces the rate and duration of readmissions, more than standard treatment, in patients with unipolar depressive disorder following hospitalization. Methods: We conducted a pragmatic, investigator-blinded, randomized controlled trial. The intervention group received a smartphone-based monitoring and treatment system in addition to standard treatment. The system allowed patients to self-monitor symptoms and access psycho-educative information and cognitive modules. The patients were allocated a study-nurse who, based on the monitoring data, guided and supported them. The control group received standard treatment. The trial lasted six months, with outcome assessments at 0, 3, and 6 months. Results: We included 120 patients with unipolar depressive disorder (ICD-10). Intention-to-treat analyses showed no statistically significant differences in time to readmission (Log-Rank p=0.9) or duration of readmissions (B=-16.41,95%CI:-47.32;25.5,p=0.3) (Primary outcomes). There were no differences in clinically rated depressive symptoms (p=0.6) or functioning (p=0.1) (secondary outcomes). The intervention group had higher levels of recovery (B=7,29, 95%CI:0.82;13,75,p=0.028) and a tendency towards higher quality of life (p=0.07), wellbeing (p=0,09) satisfaction with treatment (p=0.05) and behavioral activation (p=0.08) compared with the control group (tertiary outcomes). Limitations: Patients and study-nurses were unblinded to allocation. Conclusions: We found no effect of the intervention on primary or secondary outcomes. In tertiary outcomes, patients in the intervention group reported higher levels of recovery compared to the control group.",
keywords = "Depression, Intervention, Randomized controlled trial, Smartphone, Technology, Unipolar depressive disorder",
author = "T{\o}nning, {Morten Lindbjerg} and Maria Faurholt-Jepsen and Mads Frost and Klaus Martiny and Nanna Tuxen and Nicole Rosenberg and Jonas Busk and Ole Winther and Melbye, {Sigurd Arne} and Daniel Thaysen-Petersen and Aamund, {Kate Andreasson} and Lizzie Tolderlundh and Bardram, {Jakob Eyvind} and Kessing, {Lars Vedel}",
year = "2021",
doi = "10.1016/j.jad.2020.12.141",
language = "English",
volume = "282",
pages = "354--363",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The effect of smartphone-based monitoring and treatment on the rate and duration of psychiatric readmission in patients with unipolar depressive disorder

T2 - The RADMIS randomized controlled trial

AU - Tønning, Morten Lindbjerg

AU - Faurholt-Jepsen, Maria

AU - Frost, Mads

AU - Martiny, Klaus

AU - Tuxen, Nanna

AU - Rosenberg, Nicole

AU - Busk, Jonas

AU - Winther, Ole

AU - Melbye, Sigurd Arne

AU - Thaysen-Petersen, Daniel

AU - Aamund, Kate Andreasson

AU - Tolderlundh, Lizzie

AU - Bardram, Jakob Eyvind

AU - Kessing, Lars Vedel

PY - 2021

Y1 - 2021

N2 - Background: Patients with unipolar depressive disorder are frequently hospitalized, and the period following discharge is a high-risk-period. Smartphone-based treatments are receiving increasing attention among researchers, clinicians, and patients. We aimed to investigate whether a smartphone-based monitoring and treatment system reduces the rate and duration of readmissions, more than standard treatment, in patients with unipolar depressive disorder following hospitalization. Methods: We conducted a pragmatic, investigator-blinded, randomized controlled trial. The intervention group received a smartphone-based monitoring and treatment system in addition to standard treatment. The system allowed patients to self-monitor symptoms and access psycho-educative information and cognitive modules. The patients were allocated a study-nurse who, based on the monitoring data, guided and supported them. The control group received standard treatment. The trial lasted six months, with outcome assessments at 0, 3, and 6 months. Results: We included 120 patients with unipolar depressive disorder (ICD-10). Intention-to-treat analyses showed no statistically significant differences in time to readmission (Log-Rank p=0.9) or duration of readmissions (B=-16.41,95%CI:-47.32;25.5,p=0.3) (Primary outcomes). There were no differences in clinically rated depressive symptoms (p=0.6) or functioning (p=0.1) (secondary outcomes). The intervention group had higher levels of recovery (B=7,29, 95%CI:0.82;13,75,p=0.028) and a tendency towards higher quality of life (p=0.07), wellbeing (p=0,09) satisfaction with treatment (p=0.05) and behavioral activation (p=0.08) compared with the control group (tertiary outcomes). Limitations: Patients and study-nurses were unblinded to allocation. Conclusions: We found no effect of the intervention on primary or secondary outcomes. In tertiary outcomes, patients in the intervention group reported higher levels of recovery compared to the control group.

AB - Background: Patients with unipolar depressive disorder are frequently hospitalized, and the period following discharge is a high-risk-period. Smartphone-based treatments are receiving increasing attention among researchers, clinicians, and patients. We aimed to investigate whether a smartphone-based monitoring and treatment system reduces the rate and duration of readmissions, more than standard treatment, in patients with unipolar depressive disorder following hospitalization. Methods: We conducted a pragmatic, investigator-blinded, randomized controlled trial. The intervention group received a smartphone-based monitoring and treatment system in addition to standard treatment. The system allowed patients to self-monitor symptoms and access psycho-educative information and cognitive modules. The patients were allocated a study-nurse who, based on the monitoring data, guided and supported them. The control group received standard treatment. The trial lasted six months, with outcome assessments at 0, 3, and 6 months. Results: We included 120 patients with unipolar depressive disorder (ICD-10). Intention-to-treat analyses showed no statistically significant differences in time to readmission (Log-Rank p=0.9) or duration of readmissions (B=-16.41,95%CI:-47.32;25.5,p=0.3) (Primary outcomes). There were no differences in clinically rated depressive symptoms (p=0.6) or functioning (p=0.1) (secondary outcomes). The intervention group had higher levels of recovery (B=7,29, 95%CI:0.82;13,75,p=0.028) and a tendency towards higher quality of life (p=0.07), wellbeing (p=0,09) satisfaction with treatment (p=0.05) and behavioral activation (p=0.08) compared with the control group (tertiary outcomes). Limitations: Patients and study-nurses were unblinded to allocation. Conclusions: We found no effect of the intervention on primary or secondary outcomes. In tertiary outcomes, patients in the intervention group reported higher levels of recovery compared to the control group.

KW - Depression

KW - Intervention

KW - Randomized controlled trial

KW - Smartphone, Technology

KW - Unipolar depressive disorder

U2 - 10.1016/j.jad.2020.12.141

DO - 10.1016/j.jad.2020.12.141

M3 - Journal article

C2 - 33421863

AN - SCOPUS:85098975831

VL - 282

SP - 354

EP - 363

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 255351868