The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer
Research output: Contribution to journal › Review › Research › peer-review
Standard
The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer. / Pedersen, Stine F.; Flinck, Mette; Pardo, Luis A.
In: International Journal of Molecular Sciences, Vol. 22, No. 10, 5209, 2021.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer
AU - Pedersen, Stine F.
AU - Flinck, Mette
AU - Pardo, Luis A.
N1 - Funding Information: Work in our laboratories on this topic is supported by the European Union (H2020?MSCA? ITN?2018, grant 813834 (LAP, SFP), the Danish Cancer Society (R269?A15823, SFP), the Novo Nordisk Foundation (NNF19OC0057739, SFP), and the Max?Planck Society. We are grateful to members of our labs for valuable discussions in the process. Funding Information: Funding: Work in our laboratories on this topic is supported by the European Union (H2020‐MSCA‐ ITN‐2018, grant 813834 (LAP, SFP), the Danish Cancer Society (R269‐A15823, SFP), the Novo Nordisk Foundation (NNF19OC0057739, SFP), and the Max‐Planck Society. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Transport of ions and nutrients is a core mitochondrial function, without which there would be no mitochondrial metabolism and ATP production. Both ion homeostasis and mitochon-drial phenotype undergo pervasive changes during cancer development, and both play key roles in driving the malignancy. However, the link between these events has been largely ignored. This review comprehensively summarizes and critically discusses the role of the reciprocal relationship between ion transport and mitochondria in crucial cellular functions, including metabolism, signal-ing, and cell fate decisions. We focus on Ca2+, H+, and K+, which play essential and highly intercon-nected roles in mitochondrial function and are profoundly dysregulated in cancer. We describe the transport and roles of these ions in normal mitochondria, summarize the changes occurring during cancer development, and discuss how they might impact tumorigenesis.
AB - Transport of ions and nutrients is a core mitochondrial function, without which there would be no mitochondrial metabolism and ATP production. Both ion homeostasis and mitochon-drial phenotype undergo pervasive changes during cancer development, and both play key roles in driving the malignancy. However, the link between these events has been largely ignored. This review comprehensively summarizes and critically discusses the role of the reciprocal relationship between ion transport and mitochondria in crucial cellular functions, including metabolism, signal-ing, and cell fate decisions. We focus on Ca2+, H+, and K+, which play essential and highly intercon-nected roles in mitochondrial function and are profoundly dysregulated in cancer. We describe the transport and roles of these ions in normal mitochondria, summarize the changes occurring during cancer development, and discuss how they might impact tumorigenesis.
KW - Apoptosis
KW - Calcium
KW - Cell cycle
KW - Membrane poten-tial
KW - Metabolism
KW - Metastasis
KW - Mitochondrial fission
KW - Mitochondrial fusion
KW - PH
KW - Potassium
U2 - 10.3390/ijms22105209
DO - 10.3390/ijms22105209
M3 - Review
C2 - 34069047
AN - SCOPUS:85105718243
VL - 22
JO - International Journal of Molecular Sciences (CD-ROM)
JF - International Journal of Molecular Sciences (CD-ROM)
SN - 1424-6783
IS - 10
M1 - 5209
ER -
ID: 272576364