The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases

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Standard

The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. / Chen, Chen; Song, Xiaolei; Wei, Weixia; Zhong, Huanzi; Dai, Juanjuan; Lan, Zhou; Li, Fei; Yu, Xinlei; Feng, Qiang; Wang, Zirong; Xie, Hailiang; Chen, Xiaomin; Zeng, Chunwei; Wen, Bo; Zeng, Liping; Du, Hui; Tang, Huiru; Xu, Changlu; Xia, Yan; Xia, Huihua; Yang, Huanming; Wang, Jian; Wang, Jun; Madsen, Lise; Brix, Susanne; Kristiansen, Karsten; Xu, Xun; Li, Junhua; Wu, Ruifang; Jia, Huijue.

In: Nature Communications, Vol. 8, No. 1, 875, 17.10.2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chen, C, Song, X, Wei, W, Zhong, H, Dai, J, Lan, Z, Li, F, Yu, X, Feng, Q, Wang, Z, Xie, H, Chen, X, Zeng, C, Wen, B, Zeng, L, Du, H, Tang, H, Xu, C, Xia, Y, Xia, H, Yang, H, Wang, J, Wang, J, Madsen, L, Brix, S, Kristiansen, K, Xu, X, Li, J, Wu, R & Jia, H 2017, 'The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases', Nature Communications, vol. 8, no. 1, 875. https://doi.org/10.1038/s41467-017-00901-0

APA

Chen, C., Song, X., Wei, W., Zhong, H., Dai, J., Lan, Z., Li, F., Yu, X., Feng, Q., Wang, Z., Xie, H., Chen, X., Zeng, C., Wen, B., Zeng, L., Du, H., Tang, H., Xu, C., Xia, Y., ... Jia, H. (2017). The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nature Communications, 8(1), [875]. https://doi.org/10.1038/s41467-017-00901-0

Vancouver

Chen C, Song X, Wei W, Zhong H, Dai J, Lan Z et al. The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nature Communications. 2017 Oct 17;8(1). 875. https://doi.org/10.1038/s41467-017-00901-0

Author

Chen, Chen ; Song, Xiaolei ; Wei, Weixia ; Zhong, Huanzi ; Dai, Juanjuan ; Lan, Zhou ; Li, Fei ; Yu, Xinlei ; Feng, Qiang ; Wang, Zirong ; Xie, Hailiang ; Chen, Xiaomin ; Zeng, Chunwei ; Wen, Bo ; Zeng, Liping ; Du, Hui ; Tang, Huiru ; Xu, Changlu ; Xia, Yan ; Xia, Huihua ; Yang, Huanming ; Wang, Jian ; Wang, Jun ; Madsen, Lise ; Brix, Susanne ; Kristiansen, Karsten ; Xu, Xun ; Li, Junhua ; Wu, Ruifang ; Jia, Huijue. / The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. In: Nature Communications. 2017 ; Vol. 8, No. 1.

Bibtex

@article{b1dcf462bc464f9791467d33b1b390a5,
title = "The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases",
abstract = "Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond the vagina has been a matter of debate. Here we systematically sample the microbiota within the female reproductive tract in 110 women of reproductive age, and examine the nature of colonisation by 16S rRNA gene amplicon sequencing and cultivation. We find distinct microbial communities in cervical canal, uterus, fallopian tubes and peritoneal fluid, differing from that of the vagina. The results reflect a microbiota continuum along the female reproductive tract, indicative of a non-sterile environment. We also identify microbial taxa and potential functions that correlate with the menstrual cycle or are over-represented in subjects with adenomyosis or infertility due to endometriosis. The study provides insight into the nature of the vagino-uterine microbiome, and suggests that surveying the vaginal or cervical microbiota might be useful for detection of common diseases in the upper reproductive tract.",
author = "Chen Chen and Xiaolei Song and Weixia Wei and Huanzi Zhong and Juanjuan Dai and Zhou Lan and Fei Li and Xinlei Yu and Qiang Feng and Zirong Wang and Hailiang Xie and Xiaomin Chen and Chunwei Zeng and Bo Wen and Liping Zeng and Hui Du and Huiru Tang and Changlu Xu and Yan Xia and Huihua Xia and Huanming Yang and Jian Wang and Jun Wang and Lise Madsen and Susanne Brix and Karsten Kristiansen and Xun Xu and Junhua Li and Ruifang Wu and Huijue Jia",
year = "2017",
month = oct,
day = "17",
doi = "10.1038/s41467-017-00901-0",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases

AU - Chen, Chen

AU - Song, Xiaolei

AU - Wei, Weixia

AU - Zhong, Huanzi

AU - Dai, Juanjuan

AU - Lan, Zhou

AU - Li, Fei

AU - Yu, Xinlei

AU - Feng, Qiang

AU - Wang, Zirong

AU - Xie, Hailiang

AU - Chen, Xiaomin

AU - Zeng, Chunwei

AU - Wen, Bo

AU - Zeng, Liping

AU - Du, Hui

AU - Tang, Huiru

AU - Xu, Changlu

AU - Xia, Yan

AU - Xia, Huihua

AU - Yang, Huanming

AU - Wang, Jian

AU - Wang, Jun

AU - Madsen, Lise

AU - Brix, Susanne

AU - Kristiansen, Karsten

AU - Xu, Xun

AU - Li, Junhua

AU - Wu, Ruifang

AU - Jia, Huijue

PY - 2017/10/17

Y1 - 2017/10/17

N2 - Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond the vagina has been a matter of debate. Here we systematically sample the microbiota within the female reproductive tract in 110 women of reproductive age, and examine the nature of colonisation by 16S rRNA gene amplicon sequencing and cultivation. We find distinct microbial communities in cervical canal, uterus, fallopian tubes and peritoneal fluid, differing from that of the vagina. The results reflect a microbiota continuum along the female reproductive tract, indicative of a non-sterile environment. We also identify microbial taxa and potential functions that correlate with the menstrual cycle or are over-represented in subjects with adenomyosis or infertility due to endometriosis. The study provides insight into the nature of the vagino-uterine microbiome, and suggests that surveying the vaginal or cervical microbiota might be useful for detection of common diseases in the upper reproductive tract.

AB - Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond the vagina has been a matter of debate. Here we systematically sample the microbiota within the female reproductive tract in 110 women of reproductive age, and examine the nature of colonisation by 16S rRNA gene amplicon sequencing and cultivation. We find distinct microbial communities in cervical canal, uterus, fallopian tubes and peritoneal fluid, differing from that of the vagina. The results reflect a microbiota continuum along the female reproductive tract, indicative of a non-sterile environment. We also identify microbial taxa and potential functions that correlate with the menstrual cycle or are over-represented in subjects with adenomyosis or infertility due to endometriosis. The study provides insight into the nature of the vagino-uterine microbiome, and suggests that surveying the vaginal or cervical microbiota might be useful for detection of common diseases in the upper reproductive tract.

UR - http://www.scopus.com/inward/record.url?scp=85031789460&partnerID=8YFLogxK

U2 - 10.1038/s41467-017-00901-0

DO - 10.1038/s41467-017-00901-0

M3 - Journal article

C2 - 29042534

AN - SCOPUS:85031789460

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 875

ER -

ID: 185407487