TY - JOUR

T1 - The P-domain or trefoil motif

T2 - a role in renewal and pathology of mucous epithelia?

AU - Hoffmann, W

AU - Hauser, F

PY - 1993/7

Y1 - 1993/7

N2 - By analogy with epidermal growth factor and EGF-like repeats, the P-domain, or trefoil motif, is a characteristic shuffled module containing six invariant cysteine residues that forms the basic unit for a family of mucin-associated peptides. These P-domain peptides are potential modulators of cell growth and they are also expressed under certain pathological conditions. Furthermore, P-domains have been found as components of extracellular mosaic proteins including certain mucins, where they are thought to play a role either in protein-protein or in lectin-like interactions.

AB - By analogy with epidermal growth factor and EGF-like repeats, the P-domain, or trefoil motif, is a characteristic shuffled module containing six invariant cysteine residues that forms the basic unit for a family of mucin-associated peptides. These P-domain peptides are potential modulators of cell growth and they are also expressed under certain pathological conditions. Furthermore, P-domains have been found as components of extracellular mosaic proteins including certain mucins, where they are thought to play a role either in protein-protein or in lectin-like interactions.

KW - Amino Acid Sequence

KW - Animals

KW - Crohn Disease/metabolism

KW - Epithelium/metabolism

KW - Growth Substances/biosynthesis

KW - Humans

KW - Molecular Sequence Data

KW - Mucins

KW - Mucous Membrane/metabolism

KW - Muscle Proteins

KW - Neuropeptides

KW - Peptides

KW - Trefoil Factor-2

KW - Trefoil Factor-3

U2 - 10.1016/0968-0004(93)90170-r

DO - 10.1016/0968-0004(93)90170-r

M3 - Review

C2 - 8267796

VL - 18

SP - 239

EP - 243

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 7

ER -