The state of brain activity modulates cerebrospinal fluid transport

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The state of brain activity modulates cerebrospinal fluid transport. / Miyakoshi, Leo M.; Stæger, Frederik F.; Li, Qianliang; Pan, Chenchen; Xie, Lulu; Kang, Hongyi; Pavan, Chiara; Dang, Juliana; Sun, Qian; Ertürk, Ali; Nedergaard, Maiken.

In: Progress in Neurobiology, Vol. 229, 102512, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Miyakoshi, LM, Stæger, FF, Li, Q, Pan, C, Xie, L, Kang, H, Pavan, C, Dang, J, Sun, Q, Ertürk, A & Nedergaard, M 2023, 'The state of brain activity modulates cerebrospinal fluid transport', Progress in Neurobiology, vol. 229, 102512. https://doi.org/10.1016/j.pneurobio.2023.102512

APA

Miyakoshi, L. M., Stæger, F. F., Li, Q., Pan, C., Xie, L., Kang, H., Pavan, C., Dang, J., Sun, Q., Ertürk, A., & Nedergaard, M. (2023). The state of brain activity modulates cerebrospinal fluid transport. Progress in Neurobiology, 229, [102512]. https://doi.org/10.1016/j.pneurobio.2023.102512

Vancouver

Miyakoshi LM, Stæger FF, Li Q, Pan C, Xie L, Kang H et al. The state of brain activity modulates cerebrospinal fluid transport. Progress in Neurobiology. 2023;229. 102512. https://doi.org/10.1016/j.pneurobio.2023.102512

Author

Miyakoshi, Leo M. ; Stæger, Frederik F. ; Li, Qianliang ; Pan, Chenchen ; Xie, Lulu ; Kang, Hongyi ; Pavan, Chiara ; Dang, Juliana ; Sun, Qian ; Ertürk, Ali ; Nedergaard, Maiken. / The state of brain activity modulates cerebrospinal fluid transport. In: Progress in Neurobiology. 2023 ; Vol. 229.

Bibtex

@article{8c932c1dee944bb487d10249c7f4ebbe,
title = "The state of brain activity modulates cerebrospinal fluid transport",
abstract = "Earlier studies based on 2-photon imaging have shown that glymphatic cerebrospinal fluid (CSF) transport is regulated by the sleep-wake cycle. To examine this association, we used 3DISCO whole-body tissue clearing to map CSF tracer distribution in awake, sleeping and ketamine-xylazine anesthetized mice. The results of our analysis showed that CSF tracers entered the brain to a significantly larger extent in natural sleep or ketamine-xylazine anesthesia than in wakefulness. Furthermore, awake mice showed preferential transport of CSF tracers in the rostro-caudal direction towards the cervical and spinal cord lymphatic vessels, and hence to venous circulation and excretion by the kidneys. The study extends the current literature by showing that CSF dynamics on the whole-body scale is controlled by the state of brain activity.",
keywords = "Cerebrospinal fluid, Neurodegeneration, Neuromodulators, Perivascular spaces, Sleep, Tissue clearance",
author = "Miyakoshi, {Leo M.} and St{\ae}ger, {Frederik F.} and Qianliang Li and Chenchen Pan and Lulu Xie and Hongyi Kang and Chiara Pavan and Juliana Dang and Qian Sun and Ali Ert{\"u}rk and Maiken Nedergaard",
note = "Publisher Copyright: {\textcopyright} 2023",
year = "2023",
doi = "10.1016/j.pneurobio.2023.102512",
language = "English",
volume = "229",
journal = "Progress in Neurobiology",
issn = "0301-0082",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - The state of brain activity modulates cerebrospinal fluid transport

AU - Miyakoshi, Leo M.

AU - Stæger, Frederik F.

AU - Li, Qianliang

AU - Pan, Chenchen

AU - Xie, Lulu

AU - Kang, Hongyi

AU - Pavan, Chiara

AU - Dang, Juliana

AU - Sun, Qian

AU - Ertürk, Ali

AU - Nedergaard, Maiken

N1 - Publisher Copyright: © 2023

PY - 2023

Y1 - 2023

N2 - Earlier studies based on 2-photon imaging have shown that glymphatic cerebrospinal fluid (CSF) transport is regulated by the sleep-wake cycle. To examine this association, we used 3DISCO whole-body tissue clearing to map CSF tracer distribution in awake, sleeping and ketamine-xylazine anesthetized mice. The results of our analysis showed that CSF tracers entered the brain to a significantly larger extent in natural sleep or ketamine-xylazine anesthesia than in wakefulness. Furthermore, awake mice showed preferential transport of CSF tracers in the rostro-caudal direction towards the cervical and spinal cord lymphatic vessels, and hence to venous circulation and excretion by the kidneys. The study extends the current literature by showing that CSF dynamics on the whole-body scale is controlled by the state of brain activity.

AB - Earlier studies based on 2-photon imaging have shown that glymphatic cerebrospinal fluid (CSF) transport is regulated by the sleep-wake cycle. To examine this association, we used 3DISCO whole-body tissue clearing to map CSF tracer distribution in awake, sleeping and ketamine-xylazine anesthetized mice. The results of our analysis showed that CSF tracers entered the brain to a significantly larger extent in natural sleep or ketamine-xylazine anesthesia than in wakefulness. Furthermore, awake mice showed preferential transport of CSF tracers in the rostro-caudal direction towards the cervical and spinal cord lymphatic vessels, and hence to venous circulation and excretion by the kidneys. The study extends the current literature by showing that CSF dynamics on the whole-body scale is controlled by the state of brain activity.

KW - Cerebrospinal fluid

KW - Neurodegeneration

KW - Neuromodulators

KW - Perivascular spaces

KW - Sleep

KW - Tissue clearance

U2 - 10.1016/j.pneurobio.2023.102512

DO - 10.1016/j.pneurobio.2023.102512

M3 - Journal article

C2 - 37482196

AN - SCOPUS:85166213773

VL - 229

JO - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 0301-0082

M1 - 102512

ER -

ID: 371287343